PMID- 32077169
OWN - NLM
STAT- MEDLINE
DCOM- 20210325
LR  - 20220415
IS  - 1365-3164 (Electronic)
IS  - 0959-4493 (Linking)
VI  - 31
IP  - 4
DP  - 2020 Aug
TI  - Atopic dermatitis in a cohort of West Highland white terriers in Switzerland. 
      Part II: estimates of early life factors and heritability.
PG  - 276-e66
LID - 10.1111/vde.12843 [doi]
AB  - BACKGROUND: There is accumulating evidence in studies of allergic diseases in 
      humans and dogs that environmental experiences during the first months of life 
      can influence the development of allergic disease. No prospective study has 
      evaluated this in veterinary medicine. HYPOTHESIS/OBJECTIVES: To assess 
      early-life risk factors for canine atopic dermatitis (cAD) and estimate its 
      heritability. ANIMALS: A West Highland white terrier birth cohort (n = 107) 
      followed up to three years of age recording the development of cAD. METHODS AND 
      MATERIALS: The effect of environmental factors [house dust mites (HDM), hygiene, 
      feeding, lifestyle] and early-life determinants [breeder, mode of delivery, birth 
      season, sex, litter size, early-life immunoglobulin E (IgE) levels] were 
      assessed, using Stata SE 15.1 statistical analysis. Heritabilities were estimated 
      using the R program packages MCMCglmm and QGglmm. RESULTS: Maternal allergic 
      status [P = 0.013, odds ratio (OR 3.3)], male sex (P = 0.06), mode of delivery 
      (P = 0.12), breeder (P = 0.06), presence of HDM (P = 0.11) and environmental 
      hygiene level (P = 0.15) were identified as possible influence factors by 
      bivariate analyses. In the multivariate analysis the male sex was significantly 
      associated with the development of cAD in the offspring (P = 0.03, OR 2.4). The 
      heritabilities on the observed scale were 0.31 (direct), 0.04 (maternal genetic 
      effects) and 0.03 (maternal permanent environmental effects). CONCLUSION AND 
      CLINICAL IMPORTANCE: These results suggest that several environmental factors 
      could influence the development of cAD but clearly demonstrate the genetic 
      influence of the individual and the dam. Further studies are needed to identify 
      specific environmental factors, which could be potential targets for primary 
      disease intervention.
CI  - (c) 2020 ESVD and ACVD.
FAU - Rostaher, Ana
AU  - Rostaher A
AUID- ORCID: 0000-0002-1940-0341
AD  - Clinic for Small Animal Internal Medicine, Dermatology Unit, Vetsuisse Faculty, 
      University of Zurich, Winterthurerstrasse 260, 8057, Zurich, Switzerland.
FAU - Dolf, Gaudenz
AU  - Dolf G
AD  - Institute of Genetics, Vetsuisse Faculty, University of Berne, Bremgartenstrasse 
      109a, 3001, Berne, Switzerland.
FAU - Fischer, Nina Maria
AU  - Fischer NM
AUID- ORCID: 0000-0002-0142-226X
AD  - Clinic for Small Animal Internal Medicine, Dermatology Unit, Vetsuisse Faculty, 
      University of Zurich, Winterthurerstrasse 260, 8057, Zurich, Switzerland.
FAU - Silaghi, Cornelia
AU  - Silaghi C
AD  - Institute of Parasitology, Vetsuisse Faculty, University of Zurich, 
      Winterthurerstrasse 260, 8057, Zurich, Switzerland.
AD  - Institut fur Infektionsmedizin, Friedrich-Loeffler-Institut, Federal Research 
      Institute for Animal Health, Sudufer 10, 17493, Greifswald - Insel Riems, 
      Germany.
FAU - Akdis, Cezmi
AU  - Akdis C
AD  - Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, 
      Obere Strasse 22, 7270, Davos, Switzerland.
AD  - Christine Kuhne-Center for Allergy Research and Education, 
      Herman-Burchard-Strasse 1, 7265, Davos, Switzerland.
FAU - Zwickl, Lena
AU  - Zwickl L
AUID- ORCID: 0000-0002-5117-1112
AD  - Clinic for Small Animal Internal Medicine, Dermatology Unit, Vetsuisse Faculty, 
      University of Zurich, Winterthurerstrasse 260, 8057, Zurich, Switzerland.
FAU - Audergon, Sabrina
AU  - Audergon S
AD  - Clinic for Small Animal Internal Medicine, Dermatology Unit, Vetsuisse Faculty, 
      University of Zurich, Winterthurerstrasse 260, 8057, Zurich, Switzerland.
FAU - Favrot, Claude
AU  - Favrot C
AUID- ORCID: 0000-0002-0821-0956
AD  - Clinic for Small Animal Internal Medicine, Dermatology Unit, Vetsuisse Faculty, 
      University of Zurich, Winterthurerstrasse 260, 8057, Zurich, Switzerland.
LA  - eng
GR  - Swiss National Science Fondation/
PT  - Journal Article
PT  - Observational Study, Veterinary
DEP - 20200219
PL  - England
TA  - Vet Dermatol
JT  - Veterinary dermatology
JID - 9426187
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Allergens
MH  - Animals
MH  - Breeding
MH  - Dermatitis, Atopic/*genetics/*veterinary
MH  - Dog Diseases/etiology/*genetics
MH  - Dogs
MH  - Female
MH  - Immunoglobulin E/blood
MH  - Male
MH  - Prospective Studies
MH  - Pyroglyphidae/immunology
MH  - Risk Factors
MH  - Sex Factors
MH  - Switzerland
EDAT- 2020/02/23 06:00
MHDA- 2021/03/26 06:00
CRDT- 2020/02/21 06:00
PHST- 2020/01/03 00:00 [accepted]
PHST- 2020/02/23 06:00 [pubmed]
PHST- 2021/03/26 06:00 [medline]
PHST- 2020/02/21 06:00 [entrez]
AID - 10.1111/vde.12843 [doi]
PST - ppublish
SO  - Vet Dermatol. 2020 Aug;31(4):276-e66. doi: 10.1111/vde.12843. Epub 2020 Feb 19.