PMID- 32077474
OWN - NLM
STAT- MEDLINE
DCOM- 20201005
LR  - 20201005
IS  - 1476-6256 (Electronic)
IS  - 0002-9262 (Print)
IS  - 0002-9262 (Linking)
VI  - 189
IP  - 9
DP  - 2020 Sep 1
TI  - Microvascular Phenotyping in the Maastricht Study: Design and Main Findings, 
      2010-2018.
PG  - 873-884
LID - 10.1093/aje/kwaa023 [doi]
AB  - Microvascular dysfunction (MVD) is a common pathophysiological change that occurs 
      in various diseases, such as type 2 diabetes mellitus (T2DM), heart failure, 
      dementia, and depression. Recent technical advances have enabled noninvasive 
      measurement and quantification of microvascular changes in humans. In this paper, 
      we describe the protocols of the microvascular measurements applied in the 
      Maastricht Study, an ongoing prospective, population-based cohort study of 
      persons aged 40-75 years being carried out in the southern part of the 
      Netherlands (baseline data assessment, November 2010-January 2020). The study 
      includes a variety of noninvasive measurements in skin, retina, brain, and 
      sublingual tissue, as well as plasma and urine biomarker assessments. Following 
      this, we summarize our main findings involving these microvascular measurements 
      through the end of 2018. Finally, we provide a brief perspective on future 
      microvascular investigations within the framework of the Maastricht Study.
CI  - (c) The Author(s) 2020. Published by Oxford University Press on behalf of the Johns 
      Hopkins Bloomberg School of Public Health.
FAU - Li, Wenjie
AU  - Li W
FAU - Schram, Miranda T
AU  - Schram MT
FAU - Sorensen, Ben M
AU  - Sorensen BM
FAU - van Agtmaal, Marnix J M
AU  - van Agtmaal MJM
FAU - Berendschot, Tos T J M
AU  - Berendschot TTJM
FAU - Webers, Carroll A B
AU  - Webers CAB
FAU - Jansen, Jacobus F A
AU  - Jansen JFA
FAU - Backes, Walter H
AU  - Backes WH
FAU - Gronenschild, Ed H B M
AU  - Gronenschild EHBM
FAU - Schalkwijk, Casper G
AU  - Schalkwijk CG
FAU - Stehouwer, Coen D A
AU  - Stehouwer CDA
FAU - Houben, Alfons J H M
AU  - Houben AJHM
LA  - eng
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Epidemiol
JT  - American journal of epidemiology
JID - 7910653
RN  - 0 (Biomarkers)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers/analysis
MH  - Cardiovascular Diseases/*blood/epidemiology/*physiopathology
MH  - Diabetes Mellitus, Type 2/*blood/epidemiology/*physiopathology
MH  - Diagnostic Imaging
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Male
MH  - Microcirculation
MH  - Microvessels/diagnostic imaging/*physiopathology
MH  - Middle Aged
MH  - Netherlands/epidemiology
MH  - Phenotype
MH  - Prospective Studies
MH  - Research Design
PMC - PMC7443762
OTO - NOTNLM
OT  - cardiovascular disease
OT  - microvascular dysfunction
OT  - pathophysiology
OT  - population-based studies
OT  - type 2 diabetes
EDAT- 2020/02/23 06:00
MHDA- 2020/10/06 06:00
PMCR- 2020/02/20
CRDT- 2020/02/21 06:00
PHST- 2019/05/17 00:00 [received]
PHST- 2020/02/17 00:00 [accepted]
PHST- 2020/02/23 06:00 [pubmed]
PHST- 2020/10/06 06:00 [medline]
PHST- 2020/02/21 06:00 [entrez]
PHST- 2020/02/20 00:00 [pmc-release]
AID - 5741087 [pii]
AID - kwaa023 [pii]
AID - 10.1093/aje/kwaa023 [doi]
PST - ppublish
SO  - Am J Epidemiol. 2020 Sep 1;189(9):873-884. doi: 10.1093/aje/kwaa023.