PMID- 32078075
OWN - NLM
STAT- MEDLINE
DCOM- 20210915
LR  - 20231115
IS  - 1352-8661 (Electronic)
IS  - 0968-5243 (Print)
IS  - 0968-5243 (Linking)
VI  - 33
IP  - 5
DP  - 2020 Oct
TI  - Contrast-free high-resolution 3D magnetization transfer imaging for simultaneous 
      myocardial scar and cardiac vein visualization.
PG  - 627-640
LID - 10.1007/s10334-020-00833-9 [doi]
AB  - OBJECTIVE: To develop a three-dimensional (3D) high-resolution free-breathing 
      magnetization transfer ratio (MTR) sequence for contrast-free assessment of 
      myocardial infarct and coronary vein anatomy. MATERIALS AND METHODS: Two datasets 
      with and without off-resonance magnetization transfer preparation were 
      sequentially acquired to compute MTR. 2D image navigators enabled beat-to-beat 
      translational and bin-to-bin non-rigid motion correction. Two different imaging 
      sequences were explored. MTR scar localization was compared against 3D late 
      gadolinium enhancement (LGE) in a porcine model of myocardial infarction. MTR 
      variability across the left ventricle and vessel sharpness in the coronary veins 
      were evaluated in healthy human subjects. RESULTS: A decrease in MTR was observed 
      in areas with LGE in all pigs (non-infarct: 25.1 +/- 1.7% vs infarct: 16.8 +/- 1.9%). 
      The average infarct volume overlap on MTR and LGE was 62.5 +/- 19.2%. In humans, 
      mean MTR in myocardium was between 37 and 40%. Spatial variability was between 15 
      and 20% of the mean value. 3D whole heart MT-prepared datasets enabled coronary 
      vein visualization with up to 8% improved vessel sharpness for non-rigid compared 
      to translational motion correction. DISCUSSION: MTR and LGE showed agreement in 
      infarct detection and localization in a swine model. Free-breathing 3D MTR maps 
      are feasible in humans but high spatial variability was observed. Further 
      clinical studies are warranted.
FAU - Lopez, Karina
AU  - Lopez K
AUID- ORCID: 0000-0003-1477-8879
AD  - School of Biomedical Engineering and Imaging Sciences, King's College London, St 
      Thomas' Hospital, 3rd Floor Lambeth Wing, London, SE1 7EH, UK. 
      karina.lopez@kcl.ac.uk.
FAU - Neji, Radhouene
AU  - Neji R
AD  - School of Biomedical Engineering and Imaging Sciences, King's College London, St 
      Thomas' Hospital, 3rd Floor Lambeth Wing, London, SE1 7EH, UK.
AD  - MR Research Collaborations, Siemens Healthcare Limited, Frimley, UK.
FAU - Mukherjee, Rahul K
AU  - Mukherjee RK
AD  - School of Biomedical Engineering and Imaging Sciences, King's College London, St 
      Thomas' Hospital, 3rd Floor Lambeth Wing, London, SE1 7EH, UK.
FAU - Whitaker, John
AU  - Whitaker J
AD  - School of Biomedical Engineering and Imaging Sciences, King's College London, St 
      Thomas' Hospital, 3rd Floor Lambeth Wing, London, SE1 7EH, UK.
FAU - Phinikaridou, Alkystis
AU  - Phinikaridou A
AD  - School of Biomedical Engineering and Imaging Sciences, King's College London, St 
      Thomas' Hospital, 3rd Floor Lambeth Wing, London, SE1 7EH, UK.
FAU - Razavi, Reza
AU  - Razavi R
AD  - School of Biomedical Engineering and Imaging Sciences, King's College London, St 
      Thomas' Hospital, 3rd Floor Lambeth Wing, London, SE1 7EH, UK.
FAU - Prieto, Claudia
AU  - Prieto C
AD  - School of Biomedical Engineering and Imaging Sciences, King's College London, St 
      Thomas' Hospital, 3rd Floor Lambeth Wing, London, SE1 7EH, UK.
FAU - Roujol, Sebastien
AU  - Roujol S
AD  - School of Biomedical Engineering and Imaging Sciences, King's College London, St 
      Thomas' Hospital, 3rd Floor Lambeth Wing, London, SE1 7EH, UK.
FAU - Botnar, Rene
AU  - Botnar R
AD  - School of Biomedical Engineering and Imaging Sciences, King's College London, St 
      Thomas' Hospital, 3rd Floor Lambeth Wing, London, SE1 7EH, UK.
LA  - eng
GR  - WT_/Wellcome Trust/United Kingdom
GR  - PG/18/59/33955/BHF_/British Heart Foundation/United Kingdom
GR  - HICF-R10-698/WT_/Wellcome Trust/United Kingdom
GR  - MRC CRTF N001877/1/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
DEP - 20200220
PL  - Germany
TA  - MAGMA
JT  - Magma (New York, N.Y.)
JID - 9310752
RN  - 0 (Contrast Media)
RN  - AU0V1LM3JT (Gadolinium)
SB  - IM
MH  - Animals
MH  - *Cicatrix
MH  - Contrast Media
MH  - *Gadolinium
MH  - Imaging, Three-Dimensional
MH  - Magnetic Resonance Imaging
MH  - Myocardium/pathology
MH  - Reproducibility of Results
MH  - Swine
PMC - PMC7502043
OTO - NOTNLM
OT  - Coronary vessels
OT  - Fibrosis
OT  - Magnetic resonance imaging
COIS- R. Neji is an employee of Siemens Heathcare Limited. All other authors declare 
      that they have no conflict of interest.
EDAT- 2020/02/23 06:00
MHDA- 2021/09/16 06:00
PMCR- 2020/02/20
CRDT- 2020/02/21 06:00
PHST- 2019/07/30 00:00 [received]
PHST- 2020/01/29 00:00 [accepted]
PHST- 2020/01/27 00:00 [revised]
PHST- 2020/02/23 06:00 [pubmed]
PHST- 2021/09/16 06:00 [medline]
PHST- 2020/02/21 06:00 [entrez]
PHST- 2020/02/20 00:00 [pmc-release]
AID - 10.1007/s10334-020-00833-9 [pii]
AID - 833 [pii]
AID - 10.1007/s10334-020-00833-9 [doi]
PST - ppublish
SO  - MAGMA. 2020 Oct;33(5):627-640. doi: 10.1007/s10334-020-00833-9. Epub 2020 Feb 20.