PMID- 32078369
OWN - NLM
STAT- MEDLINE
DCOM- 20200713
LR  - 20221207
IS  - 1524-4636 (Electronic)
IS  - 1079-5642 (Linking)
VI  - 40
IP  - 4
DP  - 2020 Apr
TI  - Total White Blood Cell Count Mediated the Association Between Increased Arterial 
      Stiffness and Risk of Type 2 Diabetes Mellitus in Chinese Adults.
PG  - 1009-1015
LID - 10.1161/ATVBAHA.119.313880 [doi]
AB  - OBJECTIVE: Type 2 diabetes mellitus (T2DM) is known to be related to increased 
      arterial stiffness. However, little is known about the risk of T2DM due to 
      accelerated arterial stiffness and the underlying mechanism involved. We aimed to 
      examine arterial stiffness, as determined by brachial-ankle pulse wave velocity 
      (baPWV), in relation to T2DM among a community-based population and whether the 
      association was mediated by white blood cell (WBC) counts. Approach and results: 
      A total of 1036 Chinese adults aged 64.3 years with complete data were qualified 
      in the present study. The dose-response association between baPWV levels, WBC 
      counts, and risk of T2DM were explored using generalized linear models or 
      multivariate logistic regression models. A mediation analysis was conducted to 
      investigate the role of WBC counts on the association between baPWV and T2DM. 
      After multivariate adjustments, we observed a dose-responsive relationship 
      between increased baPWV and elevated risk of T2DM: comparing extreme tertiles of 
      baPWV, the adjusted odds ratio for T2DM risk was 2.29 (95% CI, 1.32-3.98; P for 
      trend =0.005). In addition, significant dose-dependent relationships were found 
      across baPWV tertiles with increasing total or differential WBC counts, which in 
      turn, were positively related to higher risk of T2DM (all P for trend <0.05). 
      Mediation analyses indicated that total WBC count mediated 4.5% of the 
      association between increased baPWV and elevated T2DM risk. CONCLUSIONS: 
      Increased arterial stiffness might increase T2DM risk among middle-aged and older 
      Chinese adults, which was partially mediated by total WBC count.
FAU - Liu, Yongming
AU  - Liu Y
AD  - From the Department of Neurology, Hubei No.3 People's hospital of Jianghan 
      University, Wuhan, China (Y.L.).
FAU - Lai, Xuefeng
AU  - Lai X
AD  - Department of Occupational and Environmental Health and Ministry of Education Key 
      Lab for Environment and Health, School of Public Health, Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan, China (X.L., W.G., L.M., 
      W.L., Q.F., H.Y., Y.C., M.L., X.Z., L.Y.).
FAU - Guo, Wenting
AU  - Guo W
AD  - Department of Occupational and Environmental Health and Ministry of Education Key 
      Lab for Environment and Health, School of Public Health, Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan, China (X.L., W.G., L.M., 
      W.L., Q.F., H.Y., Y.C., M.L., X.Z., L.Y.).
FAU - Ma, Lin
AU  - Ma L
AD  - Department of Occupational and Environmental Health and Ministry of Education Key 
      Lab for Environment and Health, School of Public Health, Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan, China (X.L., W.G., L.M., 
      W.L., Q.F., H.Y., Y.C., M.L., X.Z., L.Y.).
FAU - Li, Wenze
AU  - Li W
AD  - Department of Occupational and Environmental Health and Ministry of Education Key 
      Lab for Environment and Health, School of Public Health, Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan, China (X.L., W.G., L.M., 
      W.L., Q.F., H.Y., Y.C., M.L., X.Z., L.Y.).
FAU - Fang, Qin
AU  - Fang Q
AD  - Department of Occupational and Environmental Health and Ministry of Education Key 
      Lab for Environment and Health, School of Public Health, Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan, China (X.L., W.G., L.M., 
      W.L., Q.F., H.Y., Y.C., M.L., X.Z., L.Y.).
FAU - Yang, Huihua
AU  - Yang H
AD  - Department of Occupational and Environmental Health and Ministry of Education Key 
      Lab for Environment and Health, School of Public Health, Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan, China (X.L., W.G., L.M., 
      W.L., Q.F., H.Y., Y.C., M.L., X.Z., L.Y.).
FAU - Cai, Yunyao
AU  - Cai Y
AD  - Department of Occupational and Environmental Health and Ministry of Education Key 
      Lab for Environment and Health, School of Public Health, Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan, China (X.L., W.G., L.M., 
      W.L., Q.F., H.Y., Y.C., M.L., X.Z., L.Y.).
FAU - Liu, Miao
AU  - Liu M
AD  - Department of Occupational and Environmental Health and Ministry of Education Key 
      Lab for Environment and Health, School of Public Health, Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan, China (X.L., W.G., L.M., 
      W.L., Q.F., H.Y., Y.C., M.L., X.Z., L.Y.).
FAU - Zhang, Xiaomin
AU  - Zhang X
AD  - Department of Occupational and Environmental Health and Ministry of Education Key 
      Lab for Environment and Health, School of Public Health, Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan, China (X.L., W.G., L.M., 
      W.L., Q.F., H.Y., Y.C., M.L., X.Z., L.Y.).
FAU - Yang, Liangle
AU  - Yang L
AD  - Department of Occupational and Environmental Health and Ministry of Education Key 
      Lab for Environment and Health, School of Public Health, Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan, China (X.L., W.G., L.M., 
      W.L., Q.F., H.Y., Y.C., M.L., X.Z., L.Y.).
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200206
PL  - United States
TA  - Arterioscler Thromb Vasc Biol
JT  - Arteriosclerosis, thrombosis, and vascular biology
JID - 9505803
SB  - IM
MH  - Ankle Brachial Index
MH  - Asian People
MH  - Diabetes Mellitus, Type 2/ethnology/*physiopathology
MH  - Female
MH  - Humans
MH  - *Leukocyte Count
MH  - Male
MH  - Middle Aged
MH  - Obesity/physiopathology
MH  - Pulse Wave Analysis
MH  - Risk Factors
MH  - *Vascular Stiffness
OTO - NOTNLM
OT  - arterial stiffness
OT  - diabetes mellitus
OT  - white blood cell counts
EDAT- 2020/02/23 06:00
MHDA- 2020/07/14 06:00
CRDT- 2020/02/21 06:00
PHST- 2020/02/23 06:00 [pubmed]
PHST- 2020/07/14 06:00 [medline]
PHST- 2020/02/21 06:00 [entrez]
AID - 10.1161/ATVBAHA.119.313880 [doi]
PST - ppublish
SO  - Arterioscler Thromb Vasc Biol. 2020 Apr;40(4):1009-1015. doi: 
      10.1161/ATVBAHA.119.313880. Epub 2020 Feb 6.