PMID- 32079920
OWN - NLM
STAT- MEDLINE
DCOM- 20210201
LR  - 20210211
IS  - 1530-0315 (Electronic)
IS  - 0195-9131 (Linking)
VI  - 52
IP  - 8
DP  - 2020 Aug
TI  - Addition of an Alginate Hydrogel to a Carbohydrate Beverage Enhances Gastric 
      Emptying.
PG  - 1785-1792
LID - 10.1249/MSS.0000000000002301 [doi]
AB  - PURPOSE: This study aimed to examine the effect of altering osmolality or adding 
      sodium alginate and pectin to a concentrated carbohydrate (CHO) beverage on 
      gastric-emptying (GE) rate. METHODS: Boluses (500 mL) of three drinks were 
      instilled double blind in eight healthy men while seated, GE was measured using 
      the double sampling method for 90 min, and blood samples were collected 
      regularly. Drinks consisted of glucose and fructose (MON; 1392 mOsmol.kg), 
      maltodextrin and fructose (POLY; 727 mOsmol.kg), and maltodextrin, fructose, 
      sodium alginate, and pectin (ENCAP; 732 mOsmol.kg) with each providing 180 g.L 
      CHO (CHO ratio of 1:0.7 maltodextrin or glucose/fructose). RESULTS: Time to empty 
      half of the ingested bolus was faster for ENCAP (21 +/- 9 min) than for POLY (37 +/- 
      8 min); both were faster than MON (51 +/- 15 min). There were main effects for time 
      and drink in addition to an interaction effect for the volume of test drink 
      remaining in the stomach over the 90 min period, but there were no differences 
      between MON and POLY at any time point. ENCAP had a smaller volume of the test 
      drink in the stomach than MON at 30 min (193 +/- 62 vs 323 +/- 54 mL), which remained 
      less up to 60 min (93 +/- 37 vs 210 +/- 88 mL). There was a smaller volume of the 
      drink remaining in the stomach in ENCAP compared with POLY 20 min (242 +/- 73 vs 
      318 +/- 47 mL) and 30 min (193 +/- 62 vs 304 +/- 40 mL) after ingestion. Although there 
      was a main effect of time, there was no effect of drink or an interaction effect 
      on serum glucose, insulin or nonesterified fatty acid concentrations. CONCLUSION: 
      The addition of sodium alginate and pectin to a CHO beverage enhances early GE 
      rate but did not affect serum glucose, insulin, or nonesterified fatty acid 
      concentration at rest.
FAU - Sutehall, Shaun
AU  - Sutehall S
AD  - Division of Exercise Science and Sports Medicine, University of Cape Town, Cape 
      Town, SOUTH AFRICA.
FAU - Galloway, Stuart D R
AU  - Galloway SDR
AD  - Faculty of Health Sciences and Sport, University of Stirling, Stirling, UNITED 
      KINGDOM.
FAU - Bosch, Andrew
AU  - Bosch A
AD  - Division of Exercise Science and Sports Medicine, University of Cape Town, Cape 
      Town, SOUTH AFRICA.
FAU - Pitsiladis, Yannis
AU  - Pitsiladis Y
AD  - Collaborating Centre of Sports Medicine, University of Brighton, Eastbourne, 
      UNITED KINGDOM.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Med Sci Sports Exerc
JT  - Medicine and science in sports and exercise
JID - 8005433
RN  - 0 (Alginates)
RN  - 0 (Blood Glucose)
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Fatty Acids, Nonesterified)
RN  - 0 (Hydrogels)
RN  - 0 (Insulin)
RN  - 89NA02M4RX (Pectins)
SB  - IM
MH  - Adult
MH  - Alginates/*administration & dosage
MH  - *Beverages
MH  - Blood Glucose/metabolism
MH  - Dietary Carbohydrates/*administration & dosage
MH  - Double-Blind Method
MH  - Fatty Acids, Nonesterified/blood
MH  - Gastric Emptying/*physiology
MH  - Humans
MH  - Hydrogels
MH  - Insulin/blood
MH  - Male
MH  - Osmolar Concentration
MH  - Pectins/administration & dosage
MH  - Time Factors
MH  - Urine
EDAT- 2020/02/23 06:00
MHDA- 2021/02/02 06:00
CRDT- 2020/02/22 06:00
PHST- 2020/02/23 06:00 [pubmed]
PHST- 2021/02/02 06:00 [medline]
PHST- 2020/02/22 06:00 [entrez]
AID - 00005768-202008000-00017 [pii]
AID - 10.1249/MSS.0000000000002301 [doi]
PST - ppublish
SO  - Med Sci Sports Exerc. 2020 Aug;52(8):1785-1792. doi: 
      10.1249/MSS.0000000000002301.