PMID- 32080743 OWN - NLM STAT- MEDLINE DCOM- 20210517 LR - 20220129 IS - 1745-1701 (Electronic) IS - 0586-7614 (Print) IS - 0586-7614 (Linking) VI - 46 IP - 4 DP - 2020 Jul 8 TI - Emotion Recognition and Adverse Childhood Experiences in Individuals at Clinical High Risk of Psychosis. PG - 823-833 LID - 10.1093/schbul/sbz128 [doi] AB - OBJECTIVE: To investigate the association between facial affect recognition (FAR) and type of adverse childhood experiences (ACEs) in a sample of clinical high risk (CHR) individuals and a matched sample of healthy controls (HCs). METHODS: In total, 309 CHR individuals and 51 HC were recruited as part of an European Union-funded multicenter study (EU-GEI) and included in this work. During a 2-year follow-up period, 65 CHR participants made a transition to psychosis (CHR-T) and 279 did not (CHR-NT). FAR ability was measured using a computerized version of the Degraded Facial Affect Recognition (DFAR) task. ACEs were measured using the Childhood Experience of Care and Abuse Questionnaire, the Childhood Trauma Questionnaire, and the Bullying Questionnaire. Generalized regression models were used to investigate the relationship between ACE and FAR. Logistic regressions were used to investigate the relationship between FAR and psychotic transition. RESULTS: In CHR individuals, having experienced emotional abuse was associated with decreased total and neutral DFAR scores. CHR individuals who had experienced bullying performed better in the total DFAR and in the frightened condition. In HC and CHR, having experienced the death of a parent during childhood was associated with lower DFAR total score and lower neutral DFAR score, respectively. Analyses revealed a modest increase of transition risk with increasing mistakes from happy to angry faces. CONCLUSIONS: Adverse experiences in childhood seem to have a significant impact on emotional processing in adult life. This information could be helpful in a therapeutic setting where both difficulties in social interactions and adverse experiences are often addressed. CI - (c) The Author(s) 2020. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oup.com. FAU - Tognin, Stefania AU - Tognin S AD - Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. AD - Outreach and Support in South London (OASIS) Service, South London and Maudsley NHS Foundation Trust, London, UK. FAU - Catalan, Ana AU - Catalan A AD - Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. AD - Department of Psychiatry, Basurto University Hospital, Bilbao, Spain. AD - Department of Neuroscience, University of the Basque Country, Leioa, Spain. FAU - Modinos, Gemma AU - Modinos G AD - Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. AD - Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. FAU - Kempton, Matthew J AU - Kempton MJ AD - Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. AD - National Institute for Health Research (NIHR) Biomedical Research Centre (BRC), London, UK. FAU - Bilbao, Amaia AU - Bilbao A AD - Research Unit, Basurto University Hospital, Red de Investigacion en Servicios de Salud en Enfermedades Cronicas (REDISSEC), Bilbao, Spain. FAU - Nelson, Barnaby AU - Nelson B AD - Orygen, The National Centre of Excellence in Youth Mental Health, University of Melbourne, Melbourne, Australia. AD - Centre for Youth Mental Health, University of Melbourne, Melbourne, Australia. FAU - Pantelis, Christos AU - Pantelis C AD - Center for Neuropsychiatric Schizophrenia Research (CNSR) and Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS), Mental Health Centre Glostrup, University of Copenhagen, Copenhagen, Denmark. AD - Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. FAU - Riecher-Rossler, Anita AU - Riecher-Rossler A AD - University of Basel, Basel, Switzerland. FAU - Bressan, Rodrigo AU - Bressan R AD - LiNC - Lab Integrative Neuroscience, Depto Psiquiatria, Escola Paulista de Medicina, Universidade Federal de Sao Paulo - UNIFESP, Sao Paulo, Brazil. FAU - Barrantes-Vidal, Neus AU - Barrantes-Vidal N AD - Departament de Psicologia Clinica i de la Salut (Universitat Autonoma de Barcelona), Fundacio Sanitaria Sant Pere Claver, Spanish Mental Health Research Network (CIBERSAM), Madrid, Spain. FAU - Krebs, Marie-Odile AU - Krebs MO AD - INSERM, IPNP UMR S1266, Laboratoire de Physiopathologie des Maladies Psychiatriques, Universite Paris Descartes, Universite de Paris, CNRS, GDR3557-Institut de Psychiatrie, Paris, France. AD - Faculte de Medecine Paris Descartes, GHU Paris - Sainte-Anne, Service Hospitalo-Universitaire, Paris, France. FAU - Nordentoft, Merete AU - Nordentoft M AD - Mental Health Center Copenhagen and Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research, CINS, Mental Health Center Glostrup, Mental Health Services in the Capital Region of Copenhagen, University of Copenhagen, Copenhagen, Denmark. FAU - Ruhrmann, Stephan AU - Ruhrmann S AD - Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany. FAU - Sachs, Gabriele AU - Sachs G AD - Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria. FAU - Rutten, Bart P F AU - Rutten BPF AD - Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNS), Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands. FAU - van Os, Jim AU - van Os J AD - Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. AD - Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNS), Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands. AD - Department of Psychiatry, UMC Utrecht Brain Center, Utrecht University Medical Centre, Utrecht, The Netherlands. FAU - de Haan, Lieuwe AU - de Haan L AD - Department of Early Psychosis, Amsterdam UMC, Amsterdam, The Netherlands. FAU - van der Gaag, Mark AU - van der Gaag M AD - Department of Clinical Psychology and Amsterdam Public Mental Health research institute, Faculty of Behavioural and Movement Sciences, VU University, Amsterdam, The Netherlands. AD - Department of Psychosis Research, Parnassia Psychiatric Institute, The Hague, The Netherlands. CN - EU-GEI High Risk Study FAU - McGuire, Philip AU - McGuire P AD - Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. AD - Outreach and Support in South London (OASIS) Service, South London and Maudsley NHS Foundation Trust, London, UK. AD - National Institute for Health Research (NIHR) Biomedical Research Centre (BRC), London, UK. FAU - Valmaggia, Lucia R AU - Valmaggia LR AD - Department of Psychology, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. LA - eng GR - WT_/Wellcome Trust/United Kingdom GR - MR/J008915/1/MRC_/Medical Research Council/United Kingdom PT - Journal Article PT - Multicenter Study PT - Research Support, Non-U.S. Gov't PL - United States TA - Schizophr Bull JT - Schizophrenia bulletin JID - 0236760 SB - IM MH - Adolescent MH - Adult MH - *Adverse Childhood Experiences/statistics & numerical data MH - *Bullying/statistics & numerical data MH - *Child Abuse/statistics & numerical data MH - Disease Susceptibility/epidemiology MH - *Facial Recognition/physiology MH - Female MH - Follow-Up Studies MH - Humans MH - Male MH - Psychotic Disorders/*epidemiology/*physiopathology MH - Risk MH - *Social Perception MH - Young Adult PMC - PMC7345818 OTO - NOTNLM OT - childhood adversities OT - emotional processing OT - facial affect OT - psychosis risk OT - recognition OT - vulnerability to psychosis EDAT- 2020/02/23 06:00 MHDA- 2021/05/18 06:00 PMCR- 2021/07/08 CRDT- 2020/02/22 06:00 PHST- 2020/02/23 06:00 [pubmed] PHST- 2021/05/18 06:00 [medline] PHST- 2020/02/22 06:00 [entrez] PHST- 2021/07/08 00:00 [pmc-release] AID - 5742779 [pii] AID - sbz128 [pii] AID - 10.1093/schbul/sbz128 [doi] PST - ppublish SO - Schizophr Bull. 2020 Jul 8;46(4):823-833. doi: 10.1093/schbul/sbz128.