PMID- 3208081
OWN - NLM
STAT- MEDLINE
DCOM- 19890221
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 456
IP  - 2
DP  - 1988 Jul 26
TI  - Differential effects of aminopeptidase inhibitors on angiotensin-induced pressor 
      responses.
PG  - 249-53
AB  - Recent iontophoretic data suggest that conversion of angiotensin II (AII) to 
      angiotensin III (AIII) may be necessary before the peptide can activate central 
      angiotensin-sensitive neurons. Furthermore, this conversion may be inhibited by 
      the aminopeptidase A inhibitor, amastatin. In the present study we investigated 
      the importance of aminopeptidase activity on central angiotensin-induced pressor 
      responses. Intracerebroventricular (i.c.v.) pretreatment with amastatin, 
      suppressed i.c.v. AII-induced pressor responses. Pretreatment with the 
      aminopeptidase B inhibitor, bestatin, increased pressor responses to AIII. 
      Pressor responses induced by the aminopeptidase-resistant analogue, 
      [Sar1]angiotensin II, were not affected by pretreatment with angiotensin 
      inhibitors. These results support the hypothesis that AII must be converted to 
      AIII to be active in the brain.
FAU - Sullivan, M J
AU  - Sullivan MJ
AD  - Department of Psychology, Washington State University, Pullman 99164.
FAU - Harding, J W
AU  - Harding JW
FAU - Wright, J W
AU  - Wright JW
LA  - eng
GR  - R0-HL32063/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Oligopeptides)
RN  - 0 (Peptides)
RN  - 11128-99-7 (Angiotensin II)
RN  - 12687-51-3 (Angiotensin III)
RN  - 51833-69-3 (angiotensin II, Sar(1)-Ile(5)-)
RN  - 67655-94-1 (amastatin)
RN  - EC 3.4.11.- (Aminopeptidases)
RN  - GMW67QNF9C (Leucine)
RN  - I0J33N5627 (ubenimex)
SB  - IM
MH  - Aminopeptidases/*antagonists & inhibitors
MH  - Angiotensin II/administration & dosage/*analogs & derivatives/*pharmacology
MH  - Angiotensin III/administration & dosage/*pharmacology
MH  - Animals
MH  - *Anti-Bacterial Agents
MH  - Blood Pressure/*drug effects
MH  - Cerebral Ventricles/drug effects/*physiology
MH  - Injections, Intraventricular
MH  - Leucine/*analogs & derivatives/pharmacology
MH  - Male
MH  - Oligopeptides/pharmacology
MH  - *Peptides
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Reference Values
EDAT- 1988/07/26 00:00
MHDA- 1988/07/26 00:01
CRDT- 1988/07/26 00:00
PHST- 1988/07/26 00:00 [pubmed]
PHST- 1988/07/26 00:01 [medline]
PHST- 1988/07/26 00:00 [entrez]
AID - 0006-8993(88)90224-7 [pii]
AID - 10.1016/0006-8993(88)90224-7 [doi]
PST - ppublish
SO  - Brain Res. 1988 Jul 26;456(2):249-53. doi: 10.1016/0006-8993(88)90224-7.