PMID- 32081799
OWN - NLM
STAT- MEDLINE
DCOM- 20201229
LR  - 20201229
IS  - 1873-3476 (Electronic)
IS  - 0378-5173 (Linking)
VI  - 579
DP  - 2020 Apr 15
TI  - Micro vs. nano: PLGA particles loaded with trimethoprim for instillative 
      treatment of urinary tract infections.
PG  - 119158
LID - S0378-5173(20)30142-3 [pii]
LID - 10.1016/j.ijpharm.2020.119158 [doi]
AB  - Recurring infections and increasing resistances continue to complicate treatment 
      of urinary tract infections. To investigate alternative treatment options, 
      trimethoprim loaded micro- (D[4;3] of 1-9 microm) and nanoparticles (Z-Avg of 
      200-400 nm) were prepared from two types of poly(d,l-lactic-co-glycolic acid) 
      (PLGA) for instillative therapy. While PLGA 503H microparticles could not be 
      loaded with more than 2.6% trimethoprim, PLGA 2300 entrapped 22%. When preparing 
      nanoparticles, both types displayed an even higher drug load of up to 29% using 
      PLGA 2300, while PLGA 503H drug load stagnated at 10%. After eight hours, drug 
      release from microparticles amounted to 55% (503H) and 35% (2300) whereas total 
      drug release occurred after 8 (503H) and 9 days (2300). In case of nanoparticles, 
      trimethoprim was liberated much faster with 60% after 2 h and a complete release 
      after 24 h from both polymers. PLGA 2300 seems to be the better choice for 
      entrapment of trimethoprim in microparticles considering the drug load. Both 
      polymers, however, seem to be viable options for nanoparticles. Due to the higher 
      overall drug load, nanoparticles seem to be advantageous over microparticles for 
      instillative therapy, especially when prepared with PLGA 2300.
CI  - Copyright (c) 2020 Elsevier B.V. All rights reserved.
FAU - Brauner, Bernhard
AU  - Brauner B
AD  - Department of Pharmaceutical Technology and Biopharmaceutics, University of 
      Vienna, Althanstrasse 14, 1090 Vienna, Austria.
FAU - Schwarz, Patrik
AU  - Schwarz P
AD  - Department of Pharmaceutical Technology and Biopharmaceutics, University of 
      Vienna, Althanstrasse 14, 1090 Vienna, Austria.
FAU - Wirth, Michael
AU  - Wirth M
AD  - Department of Pharmaceutical Technology and Biopharmaceutics, University of 
      Vienna, Althanstrasse 14, 1090 Vienna, Austria.
FAU - Gabor, Franz
AU  - Gabor F
AD  - Department of Pharmaceutical Technology and Biopharmaceutics, University of 
      Vienna, Althanstrasse 14, 1090 Vienna, Austria. Electronic address: 
      franz.gabor@univie.ac.at.
LA  - eng
PT  - Journal Article
DEP - 20200217
PL  - Netherlands
TA  - Int J Pharm
JT  - International journal of pharmaceutics
JID - 7804127
RN  - 0 (Drug Carriers)
RN  - 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
RN  - AN164J8Y0X (Trimethoprim)
SB  - IM
MH  - Administration, Intravesical
MH  - Drug Carriers
MH  - Drug Liberation
MH  - Drug Stability
MH  - *Microspheres
MH  - Nanoparticles/administration & dosage/*chemistry/ultrastructure
MH  - Particle Size
MH  - Polylactic Acid-Polyglycolic Acid Copolymer/administration & dosage/*chemistry
MH  - Time Factors
MH  - Trimethoprim/administration & dosage/*chemistry
MH  - Urinary Tract Infections/drug therapy
OTO - NOTNLM
OT  - Instillative therapy
OT  - Microparticles
OT  - Nanoparticles
OT  - PLGA
OT  - Trimethoprim
OT  - Urinary tract infection
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2020/02/23 06:00
MHDA- 2020/12/30 06:00
CRDT- 2020/02/22 06:00
PHST- 2019/12/05 00:00 [received]
PHST- 2020/02/11 00:00 [revised]
PHST- 2020/02/16 00:00 [accepted]
PHST- 2020/02/23 06:00 [pubmed]
PHST- 2020/12/30 06:00 [medline]
PHST- 2020/02/22 06:00 [entrez]
AID - S0378-5173(20)30142-3 [pii]
AID - 10.1016/j.ijpharm.2020.119158 [doi]
PST - ppublish
SO  - Int J Pharm. 2020 Apr 15;579:119158. doi: 10.1016/j.ijpharm.2020.119158. Epub 
      2020 Feb 17.