PMID- 32082129
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 1662-5153 (Print)
IS  - 1662-5153 (Electronic)
IS  - 1662-5153 (Linking)
VI  - 14
DP  - 2020
TI  - Targeting the Stress System During Gestation: Is Early Handling a Protective 
      Strategy for the Offspring?
PG  - 9
LID - 10.3389/fnbeh.2020.00009 [doi]
LID - 9
AB  - The perinatal window is a critical developmental time when abnormal gestational 
      stimuli may alter the development of the stress system that, in turn, influences 
      behavioral and physiological responses in the newborns. Individual differences in 
      stress reactivity are also determined by variations in maternal care, resulting 
      from environmental manipulations. Despite glucocorticoids are the primary 
      programming factor for the offspring's stress response, therapeutic 
      corticosteroids are commonly used during late gestation to prevent preterm 
      negative outcomes, exposing the offspring to potentially aberrant stress 
      reactivity later in life. Thus, in this study, we investigated the consequences 
      of one daily s.c. injection of corticosterone (25 mg/kg), from gestational day 
      (GD) 14-16, and its interaction with offspring early handling, consisting in a 
      brief 15-min maternal separation until weaning, on: (i) maternal behavior; and 
      (ii) behavioral reactivity, emotional state and depressive-like behavior in the 
      adolescent offspring. Corticosterone plasma levels, under non-shock- and 
      shock-induced conditions, were also assessed. Our results show that gestational 
      exposure to corticosterone was associated with diminished maternal care, impaired 
      behavioral reactivity, increased emotional state and depressive-like behavior in 
      the offspring, associated with an aberrant corticosterone response. The early 
      handling procedure, which resulted in increased maternal care, was able to 
      counteract the detrimental effects induced by gestational corticosterone exposure 
      both in the behavioral- and neurochemical parameters examined. These findings 
      highlight the potentially detrimental consequences of targeting the stress system 
      during pregnancy as a vulnerability factor for the occurrence of emotional and 
      affective distress in the adolescent offspring. Maternal extra-care proves to be 
      a protective strategy that confers resiliency and restores homeostasis.
CI  - Copyright (c) 2020 Castelli, Lavanco, Brancato and Plescia.
FAU - Castelli, Valentina
AU  - Castelli V
AD  - Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of 
      Palermo, Palermo, Italy.
FAU - Lavanco, Gianluca
AU  - Lavanco G
AD  - INSERM U1215, Neuro Centre Magendie, Bordeaux, France.
AD  - University of Bordeaux, Bordeaux, France.
AD  - Department of Biomedical and Biotechnological Sciences, Section of Pharmacology, 
      University of Catania, Catania, Italy.
FAU - Brancato, Anna
AU  - Brancato A
AD  - Department of Health Promotion, Mother and Child Care, Internal Medicine and 
      Medical Specialties "Giuseppe D'Alessandro", University of Palermo, Palermo, 
      Italy.
FAU - Plescia, Fulvio
AU  - Plescia F
AD  - Department of Health Promotion, Mother and Child Care, Internal Medicine and 
      Medical Specialties "Giuseppe D'Alessandro", University of Palermo, Palermo, 
      Italy.
LA  - eng
PT  - Journal Article
DEP - 20200131
PL  - Switzerland
TA  - Front Behav Neurosci
JT  - Frontiers in behavioral neuroscience
JID - 101477952
PMC - PMC7006220
OTO - NOTNLM
OT  - depressive-like behavior
OT  - early handling
OT  - emotionality
OT  - glucocorticoid
OT  - prenatal exposure
OT  - stress reactivity
EDAT- 2020/02/23 06:00
MHDA- 2020/02/23 06:01
PMCR- 2020/01/01
CRDT- 2020/02/22 06:00
PHST- 2019/12/03 00:00 [received]
PHST- 2020/01/15 00:00 [accepted]
PHST- 2020/02/22 06:00 [entrez]
PHST- 2020/02/23 06:00 [pubmed]
PHST- 2020/02/23 06:01 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - 10.3389/fnbeh.2020.00009 [doi]
PST - epublish
SO  - Front Behav Neurosci. 2020 Jan 31;14:9. doi: 10.3389/fnbeh.2020.00009. 
      eCollection 2020.