PMID- 32082387
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 1687-966X (Print)
IS  - 1687-9678 (Electronic)
VI  - 2019
DP  - 2019
TI  - Human Adipose-Derived Stem Cells Promote Seawater-Immersed Wound Healing by 
      Activating Skin Stem Cells via the EGFR/MEK/ERK Pathway.
PG  - 7135974
LID - 10.1155/2019/7135974 [doi]
LID - 7135974
AB  - Seawater (SW) immersion can increase the damage of skin wounds and produce 
      refractory wounds. However, few studies have been conducted to investigate the 
      mechanisms of SW immersion on skin wounds. In our current study, we investigated 
      the effect of human adipose-derived stem cells (hADSCs) on the repair of 
      SW-treated full-thickness skin wounds and the underlying mechanisms. The results 
      showed that SW immersion could reduce the expression of EGF and suppress the 
      activation of the MEK/ERK signaling pathway. At the same time, the proliferation 
      and migration of skin stem cells were inhibited by SW immersion, resulting in 
      delayed wound healing. However, hADSCs significantly accelerated the healing of 
      SW-immersed skin wounds by promoting cell proliferation and migration through the 
      aforementioned mechanisms. Our results indicate a role for hADSCs in the repair 
      of seawater-immersed skin wounds and suggest a potential novel treatment strategy 
      for seawater-immersed wound healing.
CI  - Copyright (c) 2019 Jiachao Xiong et al.
FAU - Xiong, Jiachao
AU  - Xiong J
AD  - Department of Plastic Surgery, Changhai Hospital, Naval Military Medical 
      University, Shanghai 200433, China.
FAU - Ji, Boyao
AU  - Ji B
AD  - Department of Histology and Embryology, Naval Military Medical University, 
      Shanghai 200433, China.
FAU - Wang, Liujun
AU  - Wang L
AD  - Department of Histology and Embryology, Naval Military Medical University, 
      Shanghai 200433, China.
AD  - Shanghai Key Laboratory of Cell Engineering, Shanghai, China.
FAU - Yan, Yazhou
AU  - Yan Y
AD  - Department of Neurosurgery, Changhai Hospital, Naval Military Medical University, 
      Shanghai 200433, China.
FAU - Liu, Zhixiao
AU  - Liu Z
AD  - Department of Histology and Embryology, Naval Military Medical University, 
      Shanghai 200433, China.
AD  - Shanghai Key Laboratory of Cell Engineering, Shanghai, China.
FAU - Fang, Shuo
AU  - Fang S
AD  - Department of Plastic Surgery, Changhai Hospital, Naval Military Medical 
      University, Shanghai 200433, China.
FAU - Wu, Minjuan
AU  - Wu M
AUID- ORCID: 0000-0001-6734-5618
AD  - Department of Histology and Embryology, Naval Military Medical University, 
      Shanghai 200433, China.
AD  - Shanghai Key Laboratory of Cell Engineering, Shanghai, China.
FAU - Wang, Yue
AU  - Wang Y
AUID- ORCID: 0000-0002-0564-3019
AD  - Department of Histology and Embryology, Naval Military Medical University, 
      Shanghai 200433, China.
AD  - Shanghai Key Laboratory of Cell Engineering, Shanghai, China.
FAU - Song, Jianxing
AU  - Song J
AUID- ORCID: 0000-0002-8019-791X
AD  - Department of Plastic Surgery, Changhai Hospital, Naval Military Medical 
      University, Shanghai 200433, China.
LA  - eng
PT  - Journal Article
DEP - 20191231
PL  - United States
TA  - Stem Cells Int
JT  - Stem cells international
JID - 101535822
PMC - PMC7012271
COIS- The authors have declared that no competing interest exists.
EDAT- 2020/02/23 06:00
MHDA- 2020/02/23 06:01
PMCR- 2019/12/31
CRDT- 2020/02/22 06:00
PHST- 2019/09/13 00:00 [received]
PHST- 2019/10/31 00:00 [revised]
PHST- 2019/11/09 00:00 [accepted]
PHST- 2020/02/22 06:00 [entrez]
PHST- 2020/02/23 06:00 [pubmed]
PHST- 2020/02/23 06:01 [medline]
PHST- 2019/12/31 00:00 [pmc-release]
AID - 10.1155/2019/7135974 [doi]
PST - epublish
SO  - Stem Cells Int. 2019 Dec 31;2019:7135974. doi: 10.1155/2019/7135974. eCollection 
      2019.