PMID- 32084055
OWN - NLM
STAT- MEDLINE
DCOM- 20210106
LR  - 20220817
IS  - 1944-7884 (Electronic)
IS  - 1525-4135 (Linking)
VI  - 84
IP  - 2
DP  - 2020 Jun 1
TI  - Elevated Plasma Levels of sCD14 and MCP-1 Are Associated With HIV Associated 
      Neurocognitive Disorders Among Antiretroviral-Naive Individuals in Nigeria.
PG  - 196-202
LID - 10.1097/QAI.0000000000002320 [doi]
AB  - BACKGROUND: Mononuclear cells play key roles in the pathogenesis of 
      HIV-associated neurocognitive disorders (HAND). Limited studies have looked at 
      the association of markers of monocyte activation with HAND in Africa. We 
      examined this association among HIV-1-infected patients in Nigeria. METHOD: A 
      total of 190 HIV-infected treatment-naive participants with immune marker data 
      were included in this cross-sectional study. Plasma levels of soluble CD14 
      (sCD14), soluble CD163, monocyte chemoattractant protein-1 (MCP-1), tumor 
      necrosis factor-alpha (TNF-alpha), and neopterin were measured. Demographically 
      adjusted T scores obtained from a 7-domain neuropsychological test battery were 
      generated, and functional status was assessed using activities of daily living 
      questionnaire. Participants were classified as unimpaired, having asymptomatic 
      neurocognitive impairment (ANI), mild neurocognitive disorder (MND), or 
      HIV-associated dementia (HAD) in line with the "Frascati" criteria. RESULTS: 
      Thirty-two participants (16.8%) had ANI, 14 (7.4%) had MND, whereas none had HAD. 
      In multivariable linear regression analyses, after adjusting for age, gender, 
      education, CD4 count, and viral load, mean levels of sCD14 were higher among 
      those with ANI and MND as compared with the unimpaired (P = 0.033 and 0.023, 
      respectively). Similarly, the mean level of MCP-1 was greater among those with 
      HAND as compared with the unimpaired (P = 0.047). There were also trends for 
      higher levels of sCD163 and TNF-alpha among females with MND in univariable analyses. 
      CONCLUSIONS: Levels of monocyte activation markers correlate with the severity of 
      impairment among individuals with HAND. The mechanisms that underlie these 
      effects and the potential role of gender require further study.
FAU - Jumare, Jibreel
AU  - Jumare J
AD  - Division of Epidemiology and Prevention, Institute of Human Virology, University 
      of Maryland School of Medicine, University of Maryland School of Medicine, 
      Baltimore, MD.
FAU - Akolo, Christopher
AU  - Akolo C
AD  - Division of Epidemiology and Prevention, Institute of Human Virology, University 
      of Maryland School of Medicine, University of Maryland School of Medicine, 
      Baltimore, MD.
FAU - Ndembi, Nicaise
AU  - Ndembi N
AD  - Division of Epidemiology and Prevention, Institute of Human Virology, University 
      of Maryland School of Medicine, University of Maryland School of Medicine, 
      Baltimore, MD.
AD  - Institute of Human Virology Nigeria, Federal Capital Territory, Abuja, Nigeria.
FAU - Bwala, Sunday
AU  - Bwala S
AD  - National Hospital Abuja, Federal Capital Territory, Abuja, Nigeria.
FAU - Alabi, Peter
AU  - Alabi P
AD  - University of Abuja Teaching Hospital, Federal Capital Territory, Abuja, Nigeria.
FAU - Okwuasaba, Kanayo
AU  - Okwuasaba K
AD  - Institute of Human Virology Nigeria, Federal Capital Territory, Abuja, Nigeria.
FAU - Adebiyi, Ruxton
AU  - Adebiyi R
AD  - Institute of Human Virology Nigeria, Federal Capital Territory, Abuja, Nigeria.
FAU - Umlauf, Anya
AU  - Umlauf A
AD  - University of California San Diego, School of Medicine, San Diego, CA; and.
FAU - Cherner, Mariana
AU  - Cherner M
AD  - University of California San Diego, School of Medicine, San Diego, CA; and.
FAU - Abimiku, Alash'le
AU  - Abimiku A
AD  - Division of Epidemiology and Prevention, Institute of Human Virology, University 
      of Maryland School of Medicine, University of Maryland School of Medicine, 
      Baltimore, MD.
FAU - Charurat, Man
AU  - Charurat M
AD  - Division of Epidemiology and Prevention, Institute of Human Virology, University 
      of Maryland School of Medicine, University of Maryland School of Medicine, 
      Baltimore, MD.
FAU - Blattner, William A
AU  - Blattner WA
AD  - Division of Epidemiology and Prevention, Institute of Human Virology, University 
      of Maryland School of Medicine, University of Maryland School of Medicine, 
      Baltimore, MD.
FAU - Royal, Walter 3rd
AU  - Royal W 3rd
AD  - Division of Epidemiology and Prevention, Institute of Human Virology, University 
      of Maryland School of Medicine, University of Maryland School of Medicine, 
      Baltimore, MD.
AD  - Neuroscience Institute, Morehouse School of Medicine, Atlanta, GA.
LA  - eng
GR  - I01 BX003222/BX/BLRD VA/United States
GR  - R01 DA044908/DA/NIDA NIH HHS/United States
GR  - R01 MH086356/MH/NIMH NIH HHS/United States
GR  - D43 TW001041/TW/FIC NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - J Acquir Immune Defic Syndr
JT  - Journal of acquired immune deficiency syndromes (1999)
JID - 100892005
RN  - 0 (Anti-Retroviral Agents)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Lipopolysaccharide Receptors)
SB  - IM
MH  - AIDS Dementia Complex/*blood
MH  - Adult
MH  - Anti-Retroviral Agents/administration & dosage/*therapeutic use
MH  - Chemokine CCL2/blood/genetics/*metabolism
MH  - Female
MH  - HIV Infections/*blood/*complications
MH  - Humans
MH  - Lipopolysaccharide Receptors/blood/*metabolism
MH  - Male
MH  - Nigeria/epidemiology
EDAT- 2020/02/23 06:00
MHDA- 2021/01/07 06:00
CRDT- 2020/02/22 06:00
PHST- 2020/02/23 06:00 [pubmed]
PHST- 2021/01/07 06:00 [medline]
PHST- 2020/02/22 06:00 [entrez]
AID - 00126334-202006010-00009 [pii]
AID - 10.1097/QAI.0000000000002320 [doi]
PST - ppublish
SO  - J Acquir Immune Defic Syndr. 2020 Jun 1;84(2):196-202. doi: 
      10.1097/QAI.0000000000002320.