PMID- 32085563
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 2072-6694 (Print)
IS  - 2072-6694 (Electronic)
IS  - 2072-6694 (Linking)
VI  - 12
IP  - 2
DP  - 2020 Feb 18
TI  - Transcriptome Analysis Identifies ALCAM Overexpression as a Prognosis Biomarker 
      in Laryngeal Squamous Cell Carcinoma.
LID - 10.3390/cancers12020470 [doi]
LID - 470
AB  - BACKGROUND: Laryngeal squamous cell carcinoma (LSCC) is one of the most incident 
      tumors in the world, especially in developing countries, such as Brazil. 
      Different from other tumors, LSCC prognosis did not improve during the past four 
      decades. Therefore, the objective of this study was to develop biomarkers that 
      can predict LSCC patient's prognosis. RESULTS: Transcriptome analysis pointed out 
      287 overexpressed genes in LSCC in comparison to adjacent mucosa. Among these, a 
      gene-pattern signature was created with 24 genes associated with prognosis. The 
      Bayesian clustering of both Brazil and The Cancer Genome Atlas (TCGA) data 
      pointed out clusters of samples possessing significative differences in the 
      prognosis, and the expression panel of three genes (ALCAM, GBP6, and ME1) was 
      capable to distinguish patients with worse prognosis with an accuracy of 97%. 
      Survival analyses with TCGA data highlighted ALCAM gene expression as an 
      independent prognostic factor for LSCC. This was further confirmed through 
      immunohistochemistry, using a validation set of Brazilian patients. ALCAM 
      expression was not associated with prognosis for other head and neck tumor sites. 
      CONCLUSION: ALCAM overexpression seems to be an independent prognosis biomarker 
      for LSCC patients.
FAU - Nicolau-Neto, Pedro
AU  - Nicolau-Neto P
AD  - Programa de Carcinogenese Molecular, Instituto Nacional de Cancer-INCA, Rua Andre 
      Cavalcanti 37, Rio de Janeiro, RJ CEP 20231-050, Brazil.
FAU - de Souza-Santos, Paulo Thiago
AU  - de Souza-Santos PT
AD  - Laboratorio de Hanseniase, Instituto Oswaldo Cruz-Fiocruz, Av. Brasil, 4365 - 
      Manguinhos, Rio de Janeiro, RJ CEP 21040-900, Brazil.
FAU - Severo Ramundo, Mariana
AU  - Severo Ramundo M
AD  - Programa de Carcinogenese Molecular, Instituto Nacional de Cancer-INCA, Rua Andre 
      Cavalcanti 37, Rio de Janeiro, RJ CEP 20231-050, Brazil.
FAU - Valverde, Priscila
AU  - Valverde P
AD  - Divisao de Patologia, Instituto Nacional de Cancer-INCA, Rua Cordeiro da Graca, 
      156, Rio de Janeiro, RJ CEP 20220-400, Brazil.
FAU - Martins, Ivanir
AU  - Martins I
AD  - Divisao de Patologia, Instituto Nacional de Cancer-INCA, Rua Cordeiro da Graca, 
      156, Rio de Janeiro, RJ CEP 20220-400, Brazil.
FAU - Santos, Izabella Costa
AU  - Santos IC
AD  - Secao de Cirurgia de Cabeca e Pescoco, Instituto Nacional de Cancer-INCA, Praca 
      da Cruz Vermelha, Rio de Janeiro, RJ, CEP 20230130, Brazil.
FAU - Dias, Fernando
AU  - Dias F
AD  - Secao de Cirurgia de Cabeca e Pescoco, Instituto Nacional de Cancer-INCA, Praca 
      da Cruz Vermelha, Rio de Janeiro, RJ, CEP 20230130, Brazil.
FAU - de Almeida Simao, Tatiana
AU  - de Almeida Simao T
AD  - Departamento de Bioquimica, IBRAG, Universidade do Estado do Rio de Janeiro, Av. 
      28 de Setembro 87, Fundos, Pavilhao Americo Piquet Carneiro-4 masculine andar, Rio de 
      Janeiro, RJ CEP 20551-030, Brazil.
FAU - Ribeiro Pinto, Luis Felipe
AU  - Ribeiro Pinto LF
AD  - Programa de Carcinogenese Molecular, Instituto Nacional de Cancer-INCA, Rua Andre 
      Cavalcanti 37, Rio de Janeiro, RJ CEP 20231-050, Brazil.
AD  - Departamento de Bioquimica, IBRAG, Universidade do Estado do Rio de Janeiro, Av. 
      28 de Setembro 87, Fundos, Pavilhao Americo Piquet Carneiro-4 masculine andar, Rio de 
      Janeiro, RJ CEP 20551-030, Brazil.
LA  - eng
GR  - NA/Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior/
GR  - CNE/Fundacao Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio de 
      Janeiro/
GR  - N/A/Swiss Bridge Foundation/
GR  - N/A/Conselho Nacional de Desenvolvimento Cientifico e Tecnologico/
PT  - Journal Article
DEP - 20200218
PL  - Switzerland
TA  - Cancers (Basel)
JT  - Cancers
JID - 101526829
PMC - PMC7072229
OTO - NOTNLM
OT  - ALCAM
OT  - laryngeal squamous cell carcinoma
OT  - prognostic biomarker
OT  - transcriptome analysis
COIS- The authors declare no conflict of interest.
EDAT- 2020/02/23 06:00
MHDA- 2020/02/23 06:01
PMCR- 2020/02/18
CRDT- 2020/02/23 06:00
PHST- 2020/01/13 00:00 [received]
PHST- 2020/02/13 00:00 [revised]
PHST- 2020/02/14 00:00 [accepted]
PHST- 2020/02/23 06:00 [entrez]
PHST- 2020/02/23 06:00 [pubmed]
PHST- 2020/02/23 06:01 [medline]
PHST- 2020/02/18 00:00 [pmc-release]
AID - cancers12020470 [pii]
AID - cancers-12-00470 [pii]
AID - 10.3390/cancers12020470 [doi]
PST - epublish
SO  - Cancers (Basel). 2020 Feb 18;12(2):470. doi: 10.3390/cancers12020470.