PMID- 32085754 OWN - NLM STAT- MEDLINE DCOM- 20201204 LR - 20210110 IS - 1471-2474 (Electronic) IS - 1471-2474 (Linking) VI - 21 IP - 1 DP - 2020 Feb 21 TI - Perceived occurrence of an adverse event affects patient-reported outcomes after total hip replacement. PG - 118 LID - 10.1186/s12891-020-3127-6 [doi] LID - 118 AB - BACKGROUND: Dislocation, periprosthetic fracture and infection are serious complications of total hip replacement (THR) and which negatively impact on patients' outcomes including satisfaction, quality of life, mental health and function. The accuracy with which patients report adverse events (AEs) after surgery varies. The impact of patient self-reporting of AEs on patient-reported outcome measures (PROMs) after THR is yet to be investigated. Our aim was to determine the effect of confirmed and perceived AEs on PROMs after primary THR. METHODS: A prospective single-centre cohort study of patients undergoing primary THR, with one-year follow-up, was performed. Participants completed forms pre-operatively and 3, 6, 9 and 12 months post-operatively, including Work Productivity and Activity Impairment (WPAI), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), EuroQol-5D-3 L (EQ5D), Self-Administered Patient Satisfaction (SAPS) and AE reporting questionnaires. Results were reported in three groups: No AE, reported but not confirmed AE and confirmed AE. A generalised linear model was used to compare among groups using robust standard errors (SE). RESULTS: Forty-one AEs were reported in a cohort of 417 patients (234 females), with 30 AEs reported by 3 months. Eleven (27 reported) infections, two (six reported) periprosthetic fractures and two (eight reported) dislocations were confirmed. Those in the no AE group reported significantly better outcomes that the reported AE group as measured by WOMAC Co-Eff 14.27 (p = 0.01), EQ5D - 0.128 (p = 0.02) and SAPS - 9.926 (p = 0.036) and the combined reported and confirmed AE groups as measured by WOMAC Co-Eff 13.72 (p = 0.002), EQ5D - 0.129 (p = 0.036) and SAPS - 11.512 (p = 0.004). No significant differences were seen in WPAI among groups. CONCLUSIONS: Patients who report AEs have worse outcomes than those who do not, regardless of whether the AEs can be confirmed by standard medical record review methods. The observed negative trends suggest that patient perception of AEs may influence patient outcome in a similar way to those with confirmed AEs. FAU - Carpenter, Charlotte V E AU - Carpenter CVE AUID- ORCID: 0000-0003-3268-6062 AD - Musculoskeletal Research Unit, Translational Health Sciences, Bristol Medical School, 1st Floor Learning & Research Building, Southmead Hospital, Bristol, BS10 5NB, UK. flossie.carpenter@bristol.ac.uk. FAU - Wylde, Vikki AU - Wylde V AD - Musculoskeletal Research Unit, Translational Health Sciences, Bristol Medical School, 1st Floor Learning & Research Building, Southmead Hospital, Bristol, BS10 5NB, UK. AD - National Institute for Health Research Bristol Biomedical Research Centre, University Hospitals Bristol NHS Foundation Trust and University of Bristol, Bristol, UK. FAU - Moore, Andrew J AU - Moore AJ AD - Musculoskeletal Research Unit, Translational Health Sciences, Bristol Medical School, 1st Floor Learning & Research Building, Southmead Hospital, Bristol, BS10 5NB, UK. FAU - Sayers, Adrian AU - Sayers A AD - Musculoskeletal Research Unit, Translational Health Sciences, Bristol Medical School, 1st Floor Learning & Research Building, Southmead Hospital, Bristol, BS10 5NB, UK. FAU - Blom, Ashley W AU - Blom AW AD - Musculoskeletal Research Unit, Translational Health Sciences, Bristol Medical School, 1st Floor Learning & Research Building, Southmead Hospital, Bristol, BS10 5NB, UK. AD - National Institute for Health Research Bristol Biomedical Research Centre, University Hospitals Bristol NHS Foundation Trust and University of Bristol, Bristol, UK. FAU - Whitehouse, Michael R AU - Whitehouse MR AD - Musculoskeletal Research Unit, Translational Health Sciences, Bristol Medical School, 1st Floor Learning & Research Building, Southmead Hospital, Bristol, BS10 5NB, UK. AD - National Institute for Health Research Bristol Biomedical Research Centre, University Hospitals Bristol NHS Foundation Trust and University of Bristol, Bristol, UK. LA - eng GR - Research Capability Funding/North Bristol NHS Trust/ PT - Journal Article DEP - 20200221 PL - England TA - BMC Musculoskelet Disord JT - BMC musculoskeletal disorders JID - 100968565 SB - IM MH - Aged MH - Arthroplasty, Replacement, Hip/*adverse effects/*psychology MH - Cohort Studies MH - Female MH - Follow-Up Studies MH - Humans MH - Male MH - Middle Aged MH - *Patient Reported Outcome Measures MH - *Patient Satisfaction MH - Prospective Studies MH - Quality of Life/*psychology MH - Surveys and Questionnaires PMC - PMC7035750 OTO - NOTNLM OT - Adverse events OT - Outcomes OT - Patient reporting OT - Total hip replacement COIS- The authors declare that they have no competing interests. EDAT- 2020/02/23 06:00 MHDA- 2020/12/15 06:00 PMCR- 2020/02/21 CRDT- 2020/02/23 06:00 PHST- 2019/07/26 00:00 [received] PHST- 2020/02/10 00:00 [accepted] PHST- 2020/02/23 06:00 [entrez] PHST- 2020/02/23 06:00 [pubmed] PHST- 2020/12/15 06:00 [medline] PHST- 2020/02/21 00:00 [pmc-release] AID - 10.1186/s12891-020-3127-6 [pii] AID - 3127 [pii] AID - 10.1186/s12891-020-3127-6 [doi] PST - epublish SO - BMC Musculoskelet Disord. 2020 Feb 21;21(1):118. doi: 10.1186/s12891-020-3127-6.