PMID- 32086954
OWN - NLM
STAT- MEDLINE
DCOM- 20200908
LR  - 20211204
IS  - 1537-2995 (Electronic)
IS  - 0041-1132 (Print)
IS  - 0041-1132 (Linking)
VI  - 60
IP  - 5
DP  - 2020 May
TI  - Ensuring HLA-matched platelet support requires an ethnic diverse donor 
      population.
PG  - 940-946
LID - 10.1111/trf.15728 [doi]
AB  - BACKGROUND: Patients refractory for platelet transfusions benefit from human 
      leukocyte antigen (HLA)-matched platelet transfusions. Differences in ethnic 
      background of patients and donors could hamper the availability of sufficient 
      numbers of HLA-matched donors for all patients. We evaluated our HLA-matched 
      donor program and explored the role of ethnic background of patients related to 
      the number of available donors. METHODS: We performed a cohort study among 
      consecutive patients who received HLA-matched platelet concentrates in the 
      Netherlands between 1994 and 2017. The number of available matched donors was 
      determined per patient. Haplotypes were constructed from genotypes with computer 
      software (PyPop). Based on haplotypes, HaploStats, an algorithm from the National 
      Marrow Donor Program, was used to assess the most likely ethnic background for 
      patients with 5 or fewer and 30 or more donors. RESULTS: HLA typing was available 
      for 19,478 donors in September 2017. A total of 1206 patients received 12,350 
      HLA-matched transfusions. A median of 83 (interquartile range, 18-266) donors 
      were available per patient. For 95 (10.3%) patients, 5 or fewer donors were 
      available. These patients were more likely to have an African American 
      background, whereas patients with 30 or more donors were more often from 
      Caucasian origin, compared with Caucasian origin for patients with 30 donors. 
      CONCLUSION: Adequate transfusion support could be guaranteed for most but not all 
      refractory patients. More non-Caucasian donors are required to ensure the 
      availability of HLA-matched donors for all patients in the Netherlands.
CI  - (c) 2020 The Authors. Transfusion published by Wiley Periodicals, Inc. on behalf of 
      AABB.
FAU - Kreuger, Aukje L
AU  - Kreuger AL
AUID- ORCID: 0000-0002-1658-9257
AD  - Center for Clinical Transfusion Research, Sanquin Research, Leiden, The 
      Netherlands.
AD  - Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, 
      The Netherlands.
FAU - Haasnoot, Geert W
AU  - Haasnoot GW
AD  - Department of Immunohaematology and Blood transfusion, Leiden University Medical 
      Center, Leiden, The Netherlands.
FAU - Somers, Judith A E
AU  - Somers JAE
AD  - Unit Transfusion Medicine, Sanquin Blood Bank, Amsterdam, The Netherlands.
AD  - Department of Hematology, Erasmus MC Cancer Center, Rotterdam.
FAU - Tomson, Bert
AU  - Tomson B
AD  - Unit Transfusion Medicine, Sanquin Blood Bank, Amsterdam, The Netherlands.
FAU - van der Bon, Johanna G
AU  - van der Bon JG
AD  - Center for Clinical Transfusion Research, Sanquin Research, Leiden, The 
      Netherlands.
AD  - Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, 
      The Netherlands.
FAU - van Kraaij, Marian G J
AU  - van Kraaij MGJ
AD  - Center for Clinical Transfusion Research, Sanquin Research, Leiden, The 
      Netherlands.
AD  - Unit Transfusion Medicine, Sanquin Blood Bank, Amsterdam, The Netherlands.
AD  - Unit Donor Affairs, Sanquin Blood Bank, Amsterdam, The Netherlands.
FAU - Weller, Claudia M
AU  - Weller CM
AD  - Unit Transfusion Medicine, Sanquin Blood Bank, Amsterdam, The Netherlands.
LA  - eng
PT  - Journal Article
DEP - 20200222
PL  - United States
TA  - Transfusion
JT  - Transfusion
JID - 0417360
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Blood Donors/statistics & numerical data/*supply & distribution
MH  - Cohort Studies
MH  - Donor Selection/standards
MH  - *Ethnicity/statistics & numerical data
MH  - Female
MH  - Gene Frequency
MH  - HLA Antigens/blood/immunology
MH  - Haplotypes
MH  - Hematologic Neoplasms/blood/ethnology/*therapy
MH  - Histocompatibility Testing/methods/*standards/statistics & numerical data
MH  - Humans
MH  - Male
MH  - Netherlands/epidemiology
MH  - Platelet Transfusion/methods/*standards/statistics & numerical data
MH  - Registries
MH  - Young Adult
PMC - PMC7317777
COIS- The authors have disclosed no conflicts of interest.
EDAT- 2020/02/23 06:00
MHDA- 2020/09/09 06:00
PMCR- 2020/06/26
CRDT- 2020/02/23 06:00
PHST- 2019/09/14 00:00 [received]
PHST- 2019/12/22 00:00 [revised]
PHST- 2019/12/27 00:00 [accepted]
PHST- 2020/02/23 06:00 [pubmed]
PHST- 2020/09/09 06:00 [medline]
PHST- 2020/02/23 06:00 [entrez]
PHST- 2020/06/26 00:00 [pmc-release]
AID - TRF15728 [pii]
AID - 10.1111/trf.15728 [doi]
PST - ppublish
SO  - Transfusion. 2020 May;60(5):940-946. doi: 10.1111/trf.15728. Epub 2020 Feb 22.