PMID- 32087234
OWN - NLM
STAT- MEDLINE
DCOM- 20200527
LR  - 20200527
IS  - 1879-0631 (Electronic)
IS  - 0024-3205 (Linking)
VI  - 249
DP  - 2020 May 15
TI  - Free and hydrogel encapsulated exosome-based therapies in regenerative medicine.
PG  - 117447
LID - S0024-3205(20)30195-8 [pii]
LID - 10.1016/j.lfs.2020.117447 [doi]
AB  - Over the last few decades, mesenchymal stem cells-derived exosomes (MSCs-Ex) have 
      attracted a lot of attention as a therapeutic tool in regenerative medicine. 
      Exosomes are extracellular vehicles (EVs) that play important roles in cell-cell 
      communication through various processes such as stress response, senescence, 
      angiogenesis, and cell differentiation. Success in the field of regenerative 
      medicine sparked exploration of the potential use of exosomes as key therapeutic 
      effectors of MSCs to promote tissue regeneration. Various approaches including 
      direct injection, intravenous injection, intraperitoneal injection, oral 
      administration, and hydrogel-based encapsulation have been exploited to deliver 
      exosomes to target tissues in different disease models. Despite significant 
      advances in exosome therapy, it is unclear which approach is more effective for 
      administering exosomes. Herein, we critically review the emerging progress in the 
      applications of exosomes in the form of free or association with hydrogels as 
      therapeutic agents for applications in regenerative medicine.
CI  - Copyright (c) 2020 Elsevier Inc. All rights reserved.
FAU - Akbari, Ali
AU  - Akbari A
AD  - Solid Tumor Research Center, Research Institute for Cellular and Molecular 
      Medicine, Urmia University of Medical Sciences, Urmia, Iran.
FAU - Jabbari, Nassrollah
AU  - Jabbari N
AD  - Solid Tumor Research Center, Research Institute for Cellular and Molecular 
      Medicine, Urmia University of Medical Sciences, Urmia, Iran.
FAU - Sharifi, Roholah
AU  - Sharifi R
AD  - Schepens Eye Research Institute of Massachusetts Eye and Ear, Department of 
      Ophthalmology, Harvard Medical School, Boston, MA, United States.
FAU - Ahmadi, Mahdi
AU  - Ahmadi M
AD  - Tuberculosis and lung Diseases Research Center, Tabriz University of Medical 
      Sciences, Tabriz, Iran.
FAU - Vahhabi, Ali
AU  - Vahhabi A
AD  - Department of Immunology and Genetics, Faculty of Medicine, Urmia University of 
      Medical Sciences, Urmia, Iran.
FAU - Seyedzadeh, Seyyed Javad
AU  - Seyedzadeh SJ
AD  - Department of Medical Entomology and Vector Control, School of Public Health, 
      Urmia University of Medical Sciences, Urmia, Iran; Social Determinants of Health 
      Research Center, Urmia University of Medical Sciences, Urmia, Iran.
FAU - Nawaz, Muhammad
AU  - Nawaz M
AD  - Department of Rheumatology and Inflammation Research, Institute of Medicine, 
      Sahlgrenska Academy, University of Gothenburg, Sweden.
FAU - Szafert, Slawomir
AU  - Szafert S
AD  - Faculty of Chemistry, University of Wroclaw, F. Joliot Curie 14, 50383 Wroclaw, 
      Poland.
FAU - Mahmoodi, Monireh
AU  - Mahmoodi M
AD  - Department of biology, Faculty of Science, Arak University, Arak, Iran.
FAU - Jabbari, Esmaiel
AU  - Jabbari E
AD  - Department of Chemical Engineering, University of South Carolina, Columbia, SC, 
      United States.
FAU - Asghari, Rahim
AU  - Asghari R
AD  - Department of Oncology, Imam Khomeini hospital, Urmia University of Medical 
      Sciences, Urmia, Iran.
FAU - Rezaie, Jafar
AU  - Rezaie J
AD  - Solid Tumor Research Center, Research Institute for Cellular and Molecular 
      Medicine, Urmia University of Medical Sciences, Urmia, Iran. Electronic address: 
      Rezaie.j@umsu.ac.ir.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20200219
PL  - Netherlands
TA  - Life Sci
JT  - Life sciences
JID - 0375521
RN  - 0 (Hydrogels)
SB  - IM
MH  - Animals
MH  - *Exosomes
MH  - Humans
MH  - *Hydrogels
MH  - Mesenchymal Stem Cells/cytology
MH  - *Regenerative Medicine
OTO - NOTNLM
OT  - Exosome
OT  - Hydrogels
OT  - Mesenchymal stem cell
OT  - Regenerative medicine
COIS- Declaration of competing interest Authors declared that there is no conflict of 
      interest.
EDAT- 2020/02/23 06:00
MHDA- 2020/05/28 06:00
CRDT- 2020/02/23 06:00
PHST- 2019/12/02 00:00 [received]
PHST- 2020/02/09 00:00 [revised]
PHST- 2020/02/17 00:00 [accepted]
PHST- 2020/02/23 06:00 [pubmed]
PHST- 2020/05/28 06:00 [medline]
PHST- 2020/02/23 06:00 [entrez]
AID - S0024-3205(20)30195-8 [pii]
AID - 10.1016/j.lfs.2020.117447 [doi]
PST - ppublish
SO  - Life Sci. 2020 May 15;249:117447. doi: 10.1016/j.lfs.2020.117447. Epub 2020 Feb 
      19.