PMID- 32087528
OWN - NLM
STAT- MEDLINE
DCOM- 20201204
LR  - 20231213
IS  - 1873-4367 (Electronic)
IS  - 0927-7765 (Linking)
VI  - 189
DP  - 2020 May
TI  - Biogenic integrated ZnO/Ag nanocomposite: Surface analysis and in vivo practices 
      for the management of type 1 diabetes complications.
PG  - 110878
LID - S0927-7765(20)30108-9 [pii]
LID - 10.1016/j.colsurfb.2020.110878 [doi]
AB  - In this research, a milk thistle seed extract (MTSE)-rich medium was used as a 
      capping and reducing agent for the one-pot biosynthesis of ZnO/Ag (5 wt%) 
      nanostructure. The sample was systematically characterized through various 
      techniques and its strong biomolecule‒metal interface structure was supported by 
      the results. The efficacy of the derived nanostructure (MTSE/ZnO/Ag) was 
      evaluated in vivo on the basis of its therapeutic effects on the main 
      complications of Type 1 diabetes (hyperglycemia, hyperlipidemia, and insulin 
      deficiency). For this purpose, the changes in the plasma values of fasting blood 
      glucose, total cholesterol, total triglyceride, high-density lipoprotein 
      cholesterol, and insulin in alloxan-diabetic Wistar male rats were compared with 
      those in healthy and untreated diabetic controls after a treatment period of 16 
      days. The antidiabetic results of MTSE/ZnO/Ag were compared with those obtained 
      from pristine ZnO, MTSE, and insulin therapies. The health conditions of the rats 
      with Type 1 diabetes were significantly enhanced after treatment with MTSE/ZnO/Ag 
      (p < 0.05), which is owing to the enhanced interface structure and participatory 
      functions of the united compartments of MTSE/ZnO/Ag.
CI  - Copyright (c) 2020. Published by Elsevier B.V.
FAU - Rahim Pouran, Shima
AU  - Rahim Pouran S
AD  - Centre of Advanced Manufacturing and Materials Processing, Department of 
      Mechanical Engineering, Faculty of Engineering, University of Malaya, 50603 Kuala 
      Lumpur, Malaysia. Electronic address: sh.rahimpooran@um.edu.my.
FAU - Bayrami, Abolfazl
AU  - Bayrami A
AD  - Department of Biology, Faculty of Science, University of Mohaghegh Ardabili, P.O. 
      Box 179, Ardabil, Iran. Electronic address: a_bayrami@uma.ac.ir.
FAU - Mohammadi Arvanag, Farid
AU  - Mohammadi Arvanag F
AD  - Department of Biology, Faculty of Science, University of Mohaghegh Ardabili, P.O. 
      Box 179, Ardabil, Iran.
FAU - Habibi-Yangjeh, Aziz
AU  - Habibi-Yangjeh A
AD  - Department of Chemistry, Faculty of Science, University of Mohaghegh Ardabili, 
      P.O. Box 179, Ardabil, Iran.
FAU - Darvishi Cheshmeh Soltani, Reza
AU  - Darvishi Cheshmeh Soltani R
AD  - Department of Environmental Health Engineering, School of Health, Arak University 
      of Medical Sciences, Arak, Iran.
FAU - Singh, Ramesh
AU  - Singh R
AD  - Centre of Advanced Manufacturing and Materials Processing, Department of 
      Mechanical Engineering, Faculty of Engineering, University of Malaya, 50603 Kuala 
      Lumpur, Malaysia; Department of Mechanical Engineering, Faculty of Engineering, 
      Universiti Teknologi Brunei, Tunku Highway, Gadong BE1410, Brunei Darussalam.
FAU - Abdul Raman, Abdul Aziz
AU  - Abdul Raman AA
AD  - Chemical Engineering Department, Faculty of Engineering, University of Malaya, 
      50603 Kuala Lumpur, Malaysia.
FAU - Chae, Keun Hwa
AU  - Chae KH
AD  - Advanced Analysis Centre, Korea Institute of Science and Technology, Seoul 02792, 
      Republic of Korea.
FAU - Khataee, Alireza
AU  - Khataee A
AD  - Research Laboratory of Advanced Water and Wastewater Treatment Processes, 
      Department of Applied Chemistry, Faculty of Chemistry, University of Tabriz, 
      51666-16471 Tabriz, Iran; Department of Materials Science and Nanotechnology 
      Engineering, Faculty of Engineering, Near East University, 99138 Nicosia, TRNC, 
      Mersin 10, Turkey.
FAU - Kang, Hee Kyoung
AU  - Kang HK
AD  - Advanced Analysis Centre, Korea Institute of Science and Technology, Seoul 02792, 
      Republic of Korea.
LA  - eng
PT  - Journal Article
DEP - 20200215
PL  - Netherlands
TA  - Colloids Surf B Biointerfaces
JT  - Colloids and surfaces. B, Biointerfaces
JID - 9315133
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Plant Extracts)
RN  - 3M4G523W1G (Silver)
RN  - 6SW5YHA5NG (Alloxan)
RN  - SOI2LOH54Z (Zinc Oxide)
SB  - IM
MH  - Alloxan
MH  - Animals
MH  - Diabetes Complications/chemically induced/*drug therapy
MH  - Diabetes Mellitus, Experimental/chemically induced/drug therapy
MH  - Diabetes Mellitus, Type 1/chemically induced/*drug therapy
MH  - Hypoglycemic Agents/chemistry/isolation & purification/*therapeutic use
MH  - Male
MH  - Silybum marianum/*chemistry
MH  - Molecular Structure
MH  - Nanocomposites/*chemistry
MH  - Particle Size
MH  - Plant Extracts/chemistry/isolation & purification/*therapeutic use
MH  - Rats
MH  - Rats, Wistar
MH  - Seeds/chemistry
MH  - Silver/chemistry
MH  - Surface Properties
MH  - Zinc Oxide/chemistry
OTO - NOTNLM
OT  - Bio-metal interface
OT  - Hyperglycemia
OT  - Hyperlipidemia
OT  - Silymarin
OT  - Type 1 diabetes
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2020/02/23 06:00
MHDA- 2020/12/15 06:00
CRDT- 2020/02/23 06:00
PHST- 2019/11/20 00:00 [received]
PHST- 2020/02/14 00:00 [revised]
PHST- 2020/02/15 00:00 [accepted]
PHST- 2020/02/23 06:00 [pubmed]
PHST- 2020/12/15 06:00 [medline]
PHST- 2020/02/23 06:00 [entrez]
AID - S0927-7765(20)30108-9 [pii]
AID - 10.1016/j.colsurfb.2020.110878 [doi]
PST - ppublish
SO  - Colloids Surf B Biointerfaces. 2020 May;189:110878. doi: 
      10.1016/j.colsurfb.2020.110878. Epub 2020 Feb 15.