PMID- 32088243
OWN - NLM
STAT- MEDLINE
DCOM- 20200413
LR  - 20200413
IS  - 1879-0038 (Electronic)
IS  - 0378-1119 (Linking)
VI  - 739
DP  - 2020 May 20
TI  - Association of UCP1 polymorphisms with type 2 diabetes mellitus and their 
      interaction with physical activity and sedentary behavior.
PG  - 144497
LID - S0378-1119(20)30166-9 [pii]
LID - 10.1016/j.gene.2020.144497 [doi]
AB  - BACKGROUND: Uncoupling protein 1 (UCP1) has been reported to be associated with 
      type 2 diabetes mellitus (T2DM) in different populations, however, little is 
      reported in Chinese population. The present study aimed to explore the 
      association between some polymorphisms of UCP1 with T2DM and the interactions 
      between UCP1 and physical activity/sedentary behavior (PA/SB) lifestyle in 
      Chinese population. METHODS: Three polymorphisms (rs1472268, rs3811790 and 
      rs3811791) were genotyped in 929 T2DM patients and 1044 nondiabetic controls. The 
      data of PA and SB were acquired. Logistic regression and linear regression were 
      conducted to assess the association of UCP1 and T2DM and related traits. RESULTS: 
      The CC genotype of rs3811791 was significantly associated with an increased risk 
      of T2DM [odds ratio (OR) = 1.42, P = 0.042] and a higher level of triglyceride 
      (TG) (beta = 0.048, P = 0.034). This association still existed in the group of 
      SB >/= 3 h/d (OR = 1.66, P = 0.009) and the group of PA >/= 150 min/week and 
      SB >/= 3 h/d (OR = 1.60, P = 0.034). In the group of PA < 150 min/week and 
      SB < 3h/d, CC genotype was associated with a higher level of homeostatic model 
      assessment of insulin resistance (HOMA-IR) index, and in the group of 
      PA < 150 min/week and SB >/= 3 h/d, CC genotype was associated with increased level 
      of TG and decreased high-density lipoprotein cholesterol (HDL-C). CONCLUSION: 
      This study suggests that rs3811791 of UCP1 may be associated with T2DM and TG. 
      Moreover, we demonstrate that SB interacted with rs3811791 of UCP1 was associated 
      with T2DM, and PA interacted with rs3811791 of UCP1 was associated with the level 
      of HOMA-IR, HDL-C, and TG.
CI  - Copyright (c) 2020 Elsevier B.V. All rights reserved.
FAU - Dong, Chunting
AU  - Dong C
AD  - School of Public Health, Guangxi Medical University, Nanning 530021, People's 
      Republic of China; Guangxi Colleges and Universities Key Laboratory of Prevention 
      and Control of Highly Prevalent Diseases, Guangxi Medical University, Nanning 
      530021, People's Republic of China.
FAU - Lv, Yingnan
AU  - Lv Y
AD  - School of Public Health, Guangxi Medical University, Nanning 530021, People's 
      Republic of China; Guangxi Colleges and Universities Key Laboratory of Prevention 
      and Control of Highly Prevalent Diseases, Guangxi Medical University, Nanning 
      530021, People's Republic of China.
FAU - Xie, Lianguang
AU  - Xie L
AD  - School of Public Health, Guangxi Medical University, Nanning 530021, People's 
      Republic of China; Guangxi Colleges and Universities Key Laboratory of Prevention 
      and Control of Highly Prevalent Diseases, Guangxi Medical University, Nanning 
      530021, People's Republic of China.
FAU - Yang, Rongqing
AU  - Yang R
AD  - School of Public Health, Guangxi Medical University, Nanning 530021, People's 
      Republic of China; Guangxi Colleges and Universities Key Laboratory of Prevention 
      and Control of Highly Prevalent Diseases, Guangxi Medical University, Nanning 
      530021, People's Republic of China.
FAU - Chen, Lulin
AU  - Chen L
AD  - Third Affiliated Hospital of Guangxi Medical University, Nanning 530021, People's 
      Republic of China.
FAU - Zhang, Lulu
AU  - Zhang L
AD  - Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning 
      530021, People's Republic of China.
FAU - Long, Tianzhu
AU  - Long T
AD  - First Affiliated Hospital of Hainan Medical University, Haikou 570102, People's 
      Republic of China.
FAU - Yang, Haisheng
AU  - Yang H
AD  - School of Public Health, Guangxi Medical University, Nanning 530021, People's 
      Republic of China; Guangxi Colleges and Universities Key Laboratory of Prevention 
      and Control of Highly Prevalent Diseases, Guangxi Medical University, Nanning 
      530021, People's Republic of China.
FAU - Mao, Xingning
AU  - Mao X
AD  - School of Public Health, Guangxi Medical University, Nanning 530021, People's 
      Republic of China; Guangxi Colleges and Universities Key Laboratory of Prevention 
      and Control of Highly Prevalent Diseases, Guangxi Medical University, Nanning 
      530021, People's Republic of China.
FAU - Fan, Qiuyu
AU  - Fan Q
AD  - School of Public Health, Guangxi Medical University, Nanning 530021, People's 
      Republic of China; Guangxi Colleges and Universities Key Laboratory of Prevention 
      and Control of Highly Prevalent Diseases, Guangxi Medical University, Nanning 
      530021, People's Republic of China.
FAU - Chen, Xiaolang
AU  - Chen X
AD  - School of Public Health, Guangxi Medical University, Nanning 530021, People's 
      Republic of China; Guangxi Colleges and Universities Key Laboratory of Prevention 
      and Control of Highly Prevalent Diseases, Guangxi Medical University, Nanning 
      530021, People's Republic of China.
FAU - Zhang, Haiying
AU  - Zhang H
AD  - School of Public Health, Guangxi Medical University, Nanning 530021, People's 
      Republic of China; Guangxi Colleges and Universities Key Laboratory of Prevention 
      and Control of Highly Prevalent Diseases, Guangxi Medical University, Nanning 
      530021, People's Republic of China; Center for Genomic and Personalized Medicine, 
      Guangxi Medical University, Nanning 530021, People's Republic of China. 
      Electronic address: zhanghaiying@gxmu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20200220
PL  - Netherlands
TA  - Gene
JT  - Gene
JID - 7706761
RN  - 0 (Cholesterol, HDL)
RN  - 0 (Triglycerides)
RN  - 0 (UCP1 protein, human)
RN  - 0 (Uncoupling Protein 1)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Case-Control Studies
MH  - China
MH  - Cholesterol, HDL/analysis
MH  - Diabetes Mellitus, Type 2/*genetics
MH  - Exercise
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Insulin Resistance/genetics
MH  - Lipid Metabolism/*genetics
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - Polymorphism, Genetic/*genetics
MH  - Sedentary Behavior
MH  - Triglycerides/analysis
MH  - Uncoupling Protein 1/*genetics
OTO - NOTNLM
OT  - Insulin resistant
OT  - Lipid metabolism
OT  - Physical activity
OT  - Polymorphism
OT  - Type 2 diabetes
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2020/02/24 06:00
MHDA- 2020/04/14 06:00
CRDT- 2020/02/24 06:00
PHST- 2019/10/14 00:00 [received]
PHST- 2020/01/10 00:00 [revised]
PHST- 2020/02/19 00:00 [accepted]
PHST- 2020/02/24 06:00 [pubmed]
PHST- 2020/04/14 06:00 [medline]
PHST- 2020/02/24 06:00 [entrez]
AID - S0378-1119(20)30166-9 [pii]
AID - 10.1016/j.gene.2020.144497 [doi]
PST - ppublish
SO  - Gene. 2020 May 20;739:144497. doi: 10.1016/j.gene.2020.144497. Epub 2020 Feb 20.