PMID- 32088489
OWN - NLM
STAT- MEDLINE
DCOM- 20201230
LR  - 20201230
IS  - 1090-2147 (Electronic)
IS  - 0278-2626 (Linking)
VI  - 141
DP  - 2020 Jun
TI  - Developmental alterations of the numerical processing networks in the brain.
PG  - 105551
LID - S0278-2626(19)30326-4 [pii]
LID - 10.1016/j.bandc.2020.105551 [doi]
AB  - Neuroimaging studies revealed that number perception is mainly located in 
      parietal cortex. Although controversial, it was suggested that number is 
      processed in the frontal lobe in childhood and in the parietal cortex in 
      adulthood. The purpose of this study is to investigate developmental differences 
      in the neural correlates of number representation with fMRI. Sixteen healthy 
      young adults (age:21.69 +/- 0.79) and 15 healthy children (age:11.87 +/- 0.52) 
      performed a numerosity comparison paradigm which consists of two numerical 
      conditions with two difficulty levels. Adults showed broad parietal cortex 
      activation, as well as activation in the inferior parietal lobes, dorsolateral 
      and medial prefrontal cortex, anterior and posterior cingulate cortex, and 
      peristriate cortex (PC) during number processing. Children showed activations in 
      the intraparietal sulcus and PC. Group differences were observed in the posterior 
      insula, fusiform gyrus, and PC whose coordinates correspond to the number form 
      area (NFA). Region of interest analysis was performed for these clusters to get 
      the time series of hemodynamic responses which were estimated with a finite 
      impulse response function. In contrast to the prominent frontoparietal shift 
      theory, no age-related differences were observed in the frontoparietal regions. 
      Overall, the presented study suggests developmental changes in the brain's number 
      processing revolving around the NFA.
CI  - Copyright (c) 2020 Elsevier Inc. All rights reserved.
FAU - Vatansever, Gozde
AU  - Vatansever G
AD  - Department of Interdisciplinary Neuroscience, Ankara University, Ankara, Turkey; 
      Brain Research Center, Ankara University, Ankara, Turkey.
FAU - Ustun, Sertac
AU  - Ustun S
AD  - Department of Physiology, School of Medicine, Ankara University, Ankara, Turkey; 
      Brain Research Center, Ankara University, Ankara, Turkey.
FAU - Ayyildiz, Nazife
AU  - Ayyildiz N
AD  - Department of Interdisciplinary Neuroscience, Ankara University, Ankara, Turkey; 
      Brain Research Center, Ankara University, Ankara, Turkey.
FAU - Cicek, Metehan
AU  - Cicek M
AD  - Department of Interdisciplinary Neuroscience, Ankara University, Ankara, Turkey; 
      Department of Physiology, School of Medicine, Ankara University, Ankara, Turkey; 
      Brain Research Center, Ankara University, Ankara, Turkey. Electronic address: 
      mcicek@ankara.edu.tr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200220
PL  - United States
TA  - Brain Cogn
JT  - Brain and cognition
JID - 8218014
SB  - IM
MH  - *Brain
MH  - Brain Mapping
MH  - Cerebral Cortex
MH  - Child
MH  - Frontal Lobe
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - *Parietal Lobe
MH  - Young Adult
OTO - NOTNLM
OT  - Developmental differences
OT  - Number form area
OT  - Number perception
OT  - fMRI
COIS- Declaration of Competing Interest The authors declare that the research was 
      conducted in the absence of any commercial or financial relationships that could 
      be construed as a potential conflict of interest.
EDAT- 2020/02/24 06:00
MHDA- 2020/12/31 06:00
CRDT- 2020/02/24 06:00
PHST- 2019/07/19 00:00 [received]
PHST- 2020/01/30 00:00 [revised]
PHST- 2020/02/14 00:00 [accepted]
PHST- 2020/02/24 06:00 [pubmed]
PHST- 2020/12/31 06:00 [medline]
PHST- 2020/02/24 06:00 [entrez]
AID - S0278-2626(19)30326-4 [pii]
AID - 10.1016/j.bandc.2020.105551 [doi]
PST - ppublish
SO  - Brain Cogn. 2020 Jun;141:105551. doi: 10.1016/j.bandc.2020.105551. Epub 2020 Feb 
      20.