PMID- 32089303 OWN - NLM STAT- MEDLINE DCOM- 20201210 LR - 20201214 IS - 1525-3198 (Electronic) IS - 0022-0302 (Print) IS - 0022-0302 (Linking) VI - 103 IP - 4 DP - 2020 Apr TI - Effects of colostrum instead of formula feeding for the first 2 days postnatum on whole-body energy metabolism and its endocrine control in neonatal calves. PG - 3577-3598 LID - S0022-0302(20)30131-4 [pii] LID - 10.3168/jds.2019-17708 [doi] AB - Colostrum provides high amounts of nutritive and non-nutritive substrates, which are essential for calf nutrition and passive immunization. Colostral growth factors and hormones have beneficial effects on postnatal maturation and may affect substrate utilization and energy expenditure in neonatal calves. We tested the hypothesis that energy metabolism and its endocrine regulation differ during the first 10 d of life in calves fed either colostrum or a milk-based formula with a similar nutrient composition to colostrum, but largely depleted of bioactive substances, for the first 2 d postnatum. Male Holstein calves (n = 18) were fed either pooled colostrum (COL; n = 9) or a milk-based formula (FOR; n = 9) for the first 2 d of life. From d 3 on, all calves received same milk replacer. On d 2 and 7 of life, calves were placed in a respiration chamber for indirect calorimetric measurements to calculate heat production, fat (FOX) and carbohydrate oxidation (COX), as well as respiratory quotient. Blood was sampled on d 1 before first colostrum intake and on d 2, 3, 7, 8, 9, and 10 before morning feeding, to measure plasma concentrations of immunoglobulins, metabolites, and hormones. Additional postprandial blood samples were taken on d 1 and 9 at 30, 60, 120, 240, and 420 min after milk feeding. Liver samples were collected on d 10 of life to determine gene expression related to energy metabolism. Formula-fed calves showed lower plasma concentrations of total protein, immunoglobulins, haptoglobin, leptin, adiponectin, and insulin-like growth factor (IGF) binding protein (IGFBP)-4 during the whole study but temporarily higher plasma concentrations of urea, insulin, glucagon, triglyceride, and cholesterol on the first day after feeding, compared with concentrations in COL. The temporary increase in glucagon, triglyceride, and cholesterol on d 1 reversed on d 2 or 3, showing higher concentrations in COL than in FOR calves. In FOR, IGF-I, IGFBP-2, and IGFBP-3 were lower on d 3 than in COL. Interestingly, FOR calves had higher heat production during respiratory measurements on d 2 and higher body temperature on d 2, 3, and 5 than those of COL. The hepatic mRNA abundance of cytosolic phosphoenolpyruvate carboxykinase was higher in FOR than in COL. Our results indicate that first milk feeding after birth influenced whole-body energy expenditure but not FOX and COX in neonatal calves, and the absorption of colostral leptin and adiponectin might affect insulin sensitivity on d 1 of life. CI - Copyright (c) 2020 American Dairy Science Association. Published by Elsevier Inc. All rights reserved. FAU - Liermann, W AU - Liermann W AD - Institute of Nutritional Physiology "Oskar Kellner," Leibniz Institute for Farm Animal Biology (FBN), 18196 Dummerstorf, Germany. FAU - Schaff, C T AU - Schaff CT AD - Institute of Nutritional Physiology "Oskar Kellner," Leibniz Institute for Farm Animal Biology (FBN), 18196 Dummerstorf, Germany. FAU - Gruse, J AU - Gruse J AD - Institute of Nutritional Physiology "Oskar Kellner," Leibniz Institute for Farm Animal Biology (FBN), 18196 Dummerstorf, Germany. FAU - Derno, M AU - Derno M AD - Institute of Nutritional Physiology "Oskar Kellner," Leibniz Institute for Farm Animal Biology (FBN), 18196 Dummerstorf, Germany. FAU - Weitzel, J M AU - Weitzel JM AD - Institute of Reproductive Biology, Leibniz Institute for Farm Animal Biology, 18196 Dummerstorf, Germany. FAU - Kanitz, E AU - Kanitz E AD - Institute of Behavioural Physiology, Leibniz Institute for Farm Animal Biology, 18196 Dummerstorf, Germany. FAU - Otten, W AU - Otten W AD - Institute of Behavioural Physiology, Leibniz Institute for Farm Animal Biology, 18196 Dummerstorf, Germany. FAU - Hoeflich, A AU - Hoeflich A AD - Institute of Genome Biology Physiology, Leibniz Institute for Farm Animal Biology, 18196 Dummerstorf, Germany. FAU - Stefaniak, T AU - Stefaniak T AD - Department of Immunology, Pathophysiology and Veterinary Preventive Medicine, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Science, 50-375 Wroclaw, Poland. FAU - Sauerwein, H AU - Sauerwein H AD - Institute of Animal Science, Physiology and Hygiene Unit, University of Bonn, 53115 Germany. FAU - Bruckmaier, R M AU - Bruckmaier RM AD - Veterinary Physiology, Vetsuisse Faculty, University of Bern, 3001 Switzerland. FAU - Gross, J J AU - Gross JJ AD - Veterinary Physiology, Vetsuisse Faculty, University of Bern, 3001 Switzerland. FAU - Hammon, H M AU - Hammon HM AD - Institute of Nutritional Physiology "Oskar Kellner," Leibniz Institute for Farm Animal Biology (FBN), 18196 Dummerstorf, Germany. Electronic address: hammon@fbn-dummerstorf.de. LA - eng PT - Journal Article PT - Randomized Controlled Trial, Veterinary DEP - 20200220 PL - United States TA - J Dairy Sci JT - Journal of dairy science JID - 2985126R RN - 0 (Insulin) RN - 0 (RNA, Messenger) RN - 8W8T17847W (Urea) RN - 9007-92-5 (Glucagon) RN - 97C5T2UQ7J (Cholesterol) SB - IM MH - *Animal Feed MH - Animals MH - *Animals, Newborn MH - Cattle MH - Cholesterol/blood MH - *Colostrum/metabolism MH - Diet/veterinary MH - Endocrine System/*metabolism MH - *Energy Metabolism MH - Food, Formulated MH - Glucagon/blood MH - Insulin/blood MH - Liver/metabolism MH - Male MH - Milk/metabolism MH - Postprandial Period MH - RNA, Messenger/metabolism MH - Urea/blood PMC - PMC7127366 OTO - NOTNLM OT - biologically active substances OT - calf OT - colostrum OT - energy expenditure OT - energy metabolism EDAT- 2020/02/25 06:00 MHDA- 2020/12/15 06:00 PMCR- 2020/02/20 CRDT- 2020/02/25 06:00 PHST- 2019/10/05 00:00 [received] PHST- 2019/12/18 00:00 [accepted] PHST- 2020/02/25 06:00 [pubmed] PHST- 2020/12/15 06:00 [medline] PHST- 2020/02/25 06:00 [entrez] PHST- 2020/02/20 00:00 [pmc-release] AID - S0022-0302(20)30131-4 [pii] AID - 10.3168/jds.2019-17708 [doi] PST - ppublish SO - J Dairy Sci. 2020 Apr;103(4):3577-3598. doi: 10.3168/jds.2019-17708. Epub 2020 Feb 20.