PMID- 32089876
OWN - NLM
STAT- MEDLINE
DCOM- 20210519
LR  - 20210519
IS  - 2090-0716 (Electronic)
IS  - 2090-0708 (Print)
IS  - 2090-0708 (Linking)
VI  - 2020
DP  - 2020
TI  - Elevated Serum TNF-alpha Is Related to Obesity in Type 2 Diabetes Mellitus and Is 
      Associated with Glycemic Control and Insulin Resistance.
PG  - 5076858
LID - 10.1155/2020/5076858 [doi]
LID - 5076858
AB  - BACKGROUND: Diabetes and obesity are very common associated metabolic disorders 
      that are linked to chronic inflammation. Leptin is one of the important 
      adipokines released from adipocytes, and its level increases with increasing body 
      mass index (BMI). Tumor necrosis factor alpha (TNF-alpha) is a cytokine that is 
      released by adipocytes and inflammatory cells in response to chronic 
      inflammation. Type 2 diabetes mellitus (T2DM) is believed to be associated with 
      low-grade chronic inflammation. The current study aims to investigate the 
      involvement of leptin and TNF-alpha) is a cytokine that is released by adipocytes and 
      inflammatory cells in response to chronic inflammation. Type 2 diabetes mellitus 
      (T2DM) is believed to be associated with low-grade chronic inflammation. The 
      current study aims to investigate the involvement of leptin and TNF-Methodology. 
      This is a cross-sectional study involving 63 healthy volunteers and 65 patients 
      with T2DM. Body composition was measured, and fasting venous blood samples were 
      analyzed for blood glucose, glycosylated hemoglobin (HbA1c), basal insulin, 
      leptin, and TNF-alpha) is a cytokine that is released by adipocytes and inflammatory 
      cells in response to chronic inflammation. Type 2 diabetes mellitus (T2DM) is 
      believed to be associated with low-grade chronic inflammation. The current study 
      aims to investigate the involvement of leptin and TNF-alpha) is a cytokine that is 
      released by adipocytes and inflammatory cells in response to chronic 
      inflammation. Type 2 diabetes mellitus (T2DM) is believed to be associated with 
      low-grade chronic inflammation. The current study aims to investigate the 
      involvement of leptin and TNF. RESULTS: Our study showed a significantly higher 
      level of TNF-alpha) is a cytokine that is released by adipocytes and inflammatory 
      cells in response to chronic inflammation. Type 2 diabetes mellitus (T2DM) is 
      believed to be associated with low-grade chronic inflammation. The current study 
      aims to investigate the involvement of leptin and TNF-p=0.008). In obese diabetic 
      patients, the serum level of TNF-alpha) is a cytokine that is released by adipocytes 
      and inflammatory cells in response to chronic inflammation. Type 2 diabetes 
      mellitus (T2DM) is believed to be associated with low-grade chronic inflammation. 
      The current study aims to investigate the involvement of leptin and TNF-p=0.008). 
      In obese diabetic patients, the serum level of TNF-p=0.008). In obese diabetic 
      patients, the serum level of TNF-alpha) is a cytokine that is released by adipocytes 
      and inflammatory cells in response to chronic inflammation. Type 2 diabetes 
      mellitus (T2DM) is believed to be associated with low-grade chronic inflammation. 
      The current study aims to investigate the involvement of leptin and 
      TNF-r = 0.361, p=0.008). In obese diabetic patients, the serum level of 
      TNF-r = 0.361, p=0.008). In obese diabetic patients, the serum level of TNF. 
      CONCLUSION: TNF-alpha is associated with concurrent obesity and T2DM and correlates 
      with HbA1c. This suggests that TNF-alpha needs further investigation to explore if it 
      has a role in monitoring the effectiveness of management in individuals with 
      obesity and T2DM.alpha) is a cytokine that is released by adipocytes and inflammatory 
      cells in response to chronic inflammation. Type 2 diabetes mellitus (T2DM) is 
      believed to be associated with low-grade chronic inflammation. The current study 
      aims to investigate the involvement of leptin and TNF-alpha) is a cytokine that is 
      released by adipocytes and inflammatory cells in response to chronic 
      inflammation. Type 2 diabetes mellitus (T2DM) is believed to be associated with 
      low-grade chronic inflammation. The current study aims to investigate the 
      involvement of leptin and TNF.
CI  - Copyright (c) 2020 Hana Alzamil.
FAU - Alzamil, Hana
AU  - Alzamil H
AUID- ORCID: 0000-0002-9166-8297
AD  - Physiology Department, College of Medicine, King Saud University, Riyadh, Saudi 
      Arabia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200130
PL  - United States
TA  - J Obes
JT  - Journal of obesity
JID - 101526295
RN  - 0 (Biomarkers)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - Case-Control Studies
MH  - Cross-Sectional Studies
MH  - *Diabetes Mellitus, Type 2
MH  - Female
MH  - Glycemic Control
MH  - Humans
MH  - Insulin Resistance
MH  - Male
MH  - Middle Aged
MH  - *Obesity
MH  - Tumor Necrosis Factor-alpha/*blood
PMC - PMC7013317
COIS- The author declares that there are no conflicts of interest regarding the 
      publication of this paper.
EDAT- 2020/02/25 06:00
MHDA- 2021/05/20 06:00
PMCR- 2020/01/30
CRDT- 2020/02/25 06:00
PHST- 2019/08/20 00:00 [received]
PHST- 2019/10/22 00:00 [accepted]
PHST- 2020/02/25 06:00 [entrez]
PHST- 2020/02/25 06:00 [pubmed]
PHST- 2021/05/20 06:00 [medline]
PHST- 2020/01/30 00:00 [pmc-release]
AID - 10.1155/2020/5076858 [doi]
PST - epublish
SO  - J Obes. 2020 Jan 30;2020:5076858. doi: 10.1155/2020/5076858. eCollection 2020.