PMID- 32089894
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220413
IS  - 2090-3545 (Print)
IS  - 2090-3553 (Electronic)
IS  - 2090-3553 (Linking)
VI  - 2020
DP  - 2020
TI  - An fMRI Study of the Effects of Vibroacoustic Stimulation on Functional 
      Connectivity in Patients with Insomnia.
PG  - 7846914
LID - 10.1155/2020/7846914 [doi]
LID - 7846914
AB  - BACKGROUND: It is well known that vibratory and auditory stimuli from vehicles 
      such as cars and trains can help induce sleep. More recent literature suggests 
      that specific types of vibratory and acoustic stimulation might help promote 
      sleep, but this has not been tested with neuroimaging. Thus, the purpose of this 
      study was to observe the effects of vibroacoustic stimulation (providing both 
      vibratory and auditory stimuli) on functional connectivity changes in the brain 
      using resting state functional magnetic resonance imaging (rs-fMRI), and compare 
      these changes to improvements in sleep in patients with insomnia. METHODS: For 
      this study, 30 patients with insomnia were randomly assigned to receive one month 
      of a vibroacoustic stimulation or be placed in a waitlist control. Patients were 
      evaluated pre- and postprogram with qualitative sleep questionnaires and 
      measurement of sleep duration with an actigraphy watch. In addition, patients 
      underwent rs-fMRI to assess functional connectivity. RESULTS: The results 
      demonstrated that those patients receiving the vibroacoustic stimulation had 
      significant improvements in measured sleep minutes as well as in scores on the 
      Insomnia Severity Index questionnaire. In addition, significant changes were 
      noted in functional connectivity in association with the vermis, cerebellar 
      hemispheres, thalamus, sensorimotor area, nucleus accumbens, and prefrontal 
      cortex. CONCLUSIONS: The results of this study show that vibroacoustic 
      stimulation alters the brain's functional connectivity as well as improves sleep 
      in patients with insomnia.
CI  - Copyright (c) 2020 George Zabrecky et al.
FAU - Zabrecky, George
AU  - Zabrecky G
AD  - Department of Integrative Medicine and Nutritional Sciences, Thomas Jefferson 
      University, Philadelphia, PA 19107, USA.
FAU - Shahrampour, Shiva
AU  - Shahrampour S
AD  - Department of Radiology, Thomas Jefferson University, Philadelphia, PA 19107, 
      USA.
FAU - Whitely, Cutler
AU  - Whitely C
AD  - Department of Integrative Medicine and Nutritional Sciences, Thomas Jefferson 
      University, Philadelphia, PA 19107, USA.
FAU - Alizadeh, Mahdi
AU  - Alizadeh M
AD  - Department of Radiology, Thomas Jefferson University, Philadelphia, PA 19107, 
      USA.
FAU - Conklin, Chris
AU  - Conklin C
AD  - Department of Radiology, Thomas Jefferson University, Philadelphia, PA 19107, 
      USA.
FAU - Wintering, Nancy
AU  - Wintering N
AD  - Department of Integrative Medicine and Nutritional Sciences, Thomas Jefferson 
      University, Philadelphia, PA 19107, USA.
FAU - Doghramji, Karl
AU  - Doghramji K
AD  - Sleep Disorders Center, Department of Psychiatry and Human Behavior, Thomas 
      Jefferson University, Philadelphia, PA 19107, USA.
FAU - Zhan, Tingting
AU  - Zhan T
AUID- ORCID: 0000-0001-9971-4844
AD  - Department of Biostatistics, Thomas Jefferson University, Philadelphia, PA 19107, 
      USA.
FAU - Mohamed, Feroze
AU  - Mohamed F
AD  - Department of Radiology, Thomas Jefferson University, Philadelphia, PA 19107, 
      USA.
FAU - Newberg, Andrew
AU  - Newberg A
AUID- ORCID: 0000-0001-8230-1752
AD  - Department of Integrative Medicine and Nutritional Sciences, Thomas Jefferson 
      University, Philadelphia, PA 19107, USA.
AD  - Department of Radiology, Thomas Jefferson University, Philadelphia, PA 19107, 
      USA.
FAU - Monti, Daniel
AU  - Monti D
AD  - Department of Integrative Medicine and Nutritional Sciences, Thomas Jefferson 
      University, Philadelphia, PA 19107, USA.
LA  - eng
PT  - Journal Article
DEP - 20200204
PL  - United States
TA  - Sleep Disord
JT  - Sleep disorders
JID - 101600304
PMC - PMC7024098
COIS- No authors have any financial conflict of interest related to the study.
EDAT- 2020/02/25 06:00
MHDA- 2020/02/25 06:01
PMCR- 2020/02/04
CRDT- 2020/02/25 06:00
PHST- 2019/12/12 00:00 [received]
PHST- 2020/01/23 00:00 [accepted]
PHST- 2020/02/25 06:00 [entrez]
PHST- 2020/02/25 06:00 [pubmed]
PHST- 2020/02/25 06:01 [medline]
PHST- 2020/02/04 00:00 [pmc-release]
AID - 10.1155/2020/7846914 [doi]
PST - epublish
SO  - Sleep Disord. 2020 Feb 4;2020:7846914. doi: 10.1155/2020/7846914. eCollection 
      2020.