PMID- 32090044
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 2222-3959 (Print)
IS  - 2227-4898 (Electronic)
IS  - 2222-3959 (Linking)
VI  - 13
IP  - 2
DP  - 2020
TI  - Biomarkers in retinoblastoma.
PG  - 325-341
LID - 10.18240/ijo.2020.02.18 [doi]
AB  - Retinoblastoma (RB) is the most common intraocular malignancy of childhood caused 
      by inactivation of the Rb genes. The prognosis of RB is better with an earlier 
      diagnosis. Many diagnostic approaches and appropriate clinical treatments have 
      been developed to improve clinical outcomes. However, limitations exist when 
      utilizing current methods. Recently, many studies have identified identify new RB 
      biomarkers which can be used in diagnosis, as prognostic indicators and may 
      contribute to understanding the pathogenesis of RB and help determine specific 
      treatment strategies. This review focuses on recent advances in the discovery of 
      RB biomarkers and discusses their clinical utility and challenges from areas such 
      as epigenetics, proteomics and radiogenomics.
CI  - International Journal of Ophthalmology Press.
FAU - Sun, Jie
AU  - Sun J
AD  - Department of Ophthalmology, the First Affiliated Hospital of Nanjing Medical 
      University, Nanjing 210029, Jiangsu Province, China.
FAU - Xi, Hui-Yu
AU  - Xi HY
AD  - Department of Ophthalmology, the First Affiliated Hospital of Nanjing Medical 
      University, Nanjing 210029, Jiangsu Province, China.
AD  - Department of Ophthalmology, Xuzhou First People's Hospital of Xuzhou Medical 
      University, Xuzhou Eye Research Institute, Xuzhou 221002, Jiangsu Province, 
      China.
FAU - Shao, Qing
AU  - Shao Q
AD  - Department of Ophthalmology, the First Affiliated Hospital of Nanjing Medical 
      University, Nanjing 210029, Jiangsu Province, China.
FAU - Liu, Qing-Huai
AU  - Liu QH
AD  - Department of Ophthalmology, the First Affiliated Hospital of Nanjing Medical 
      University, Nanjing 210029, Jiangsu Province, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20200218
PL  - China
TA  - Int J Ophthalmol
JT  - International journal of ophthalmology
JID - 101553860
PMC - PMC7013786
OTO - NOTNLM
OT  - biomarkers
OT  - epigenetics
OT  - proteomics
OT  - radiogenomics
OT  - retinoblastoma
EDAT- 2020/02/25 06:00
MHDA- 2020/02/25 06:01
PMCR- 2020/02/18
CRDT- 2020/02/25 06:00
PHST- 2019/03/19 00:00 [received]
PHST- 2019/10/22 00:00 [accepted]
PHST- 2020/02/25 06:00 [entrez]
PHST- 2020/02/25 06:00 [pubmed]
PHST- 2020/02/25 06:01 [medline]
PHST- 2020/02/18 00:00 [pmc-release]
AID - ijo-13-02-325 [pii]
AID - 10.18240/ijo.2020.02.18 [doi]
PST - epublish
SO  - Int J Ophthalmol. 2020 Feb 18;13(2):325-341. doi: 10.18240/ijo.2020.02.18. 
      eCollection 2020.