PMID- 32090105
OWN - NLM
STAT- MEDLINE
DCOM- 20201124
LR  - 20220413
IS  - 2314-6141 (Electronic)
IS  - 2314-6133 (Print)
VI  - 2020
DP  - 2020
TI  - H-Type Hypertension Is a Risk Factor for Cerebral Small-Vessel Disease.
PG  - 6498903
LID - 10.1155/2020/6498903 [doi]
LID - 6498903
AB  - BACKGROUND: The correlation between H-type hypertension and cerebral small-vessel 
      diseases (CSVD) remains uncertain. OBJECTIVE: The present study was designed to 
      explore the possible relationship between H-type hypertension and CSVD spectrum 
      and total burden. METHOD: We included 329 patients in the present study and 
      divided them into four groups: the H-type hypertension group, isolated 
      hypertension group, isolated hyperhomocysteinemia (HHcy) group, and control 
      group. Clinical variables of interest and the MR examination sequences were 
      obtained. We counted the presence of each CSVD feature and rated the total burden 
      of CSVD on an ordinal scale from 0 to 4 according to a recent described score 
      rule. RESULT: The results showed that H-type hypertension was associated with the 
      presence of cerebral microbleeds (CMBs), and the severity of white-matter 
      hyperintensities (WMHs) and peripheral vascular space (PVS). CSVD total burden 
      was significantly related to age (OR: 1.059, 95% CI: 1.037-1.082), systolic 
      pressure (OR: 1.122, 95% CI: 1.007-1.136), triglycerides (OR: 1.386, 95% CI: 
      1.037-1.854), isolated HHcy (OR: 4.154, 95% CI 1.836-9.401), and H-type 
      hypertension (OR: 5.028, 95% CI: 2.323-10.883). Also, we further observed 
      hypertension and HHcy had a synergistic effect on CSVD total burden (OR: 2.776, 
      95% CI: 1.564-4.927). CONCLUSION: H-type hypertension was associated with CSVD 
      total burden and CSVD spectrum, which deserves further prevention measures. 
      Furthermore, hypertension and HHcy had a synergistic effect on CSVD total burden.
CI  - Copyright (c) 2020 Tan Li et al.
FAU - Li, Tan
AU  - Li T
AUID- ORCID: 0000-0002-1684-9004
AD  - Department of Neurology, The First Affiliated Hospital of Soochow University, No. 
      899 Pinghai Road, Suzhou, Jiangsu 215006, China.
FAU - Liu, Xueyun
AU  - Liu X
AD  - Department of Neurology, The First Affiliated Hospital of Soochow University, No. 
      899 Pinghai Road, Suzhou, Jiangsu 215006, China.
FAU - Diao, Shanshan
AU  - Diao S
AD  - Department of Neurology, The First Affiliated Hospital of Soochow University, No. 
      899 Pinghai Road, Suzhou, Jiangsu 215006, China.
FAU - Kong, Yan
AU  - Kong Y
AUID- ORCID: 0000-0001-6599-2416
AD  - Department of Neurology, The First Affiliated Hospital of Soochow University, No. 
      899 Pinghai Road, Suzhou, Jiangsu 215006, China.
FAU - Duan, Xiaoyu
AU  - Duan X
AD  - Department of Neurology, The First Affiliated Hospital of Soochow University, No. 
      899 Pinghai Road, Suzhou, Jiangsu 215006, China.
FAU - Yang, Si
AU  - Yang S
AD  - Department of Neurology, The First Affiliated Hospital of Soochow University, No. 
      899 Pinghai Road, Suzhou, Jiangsu 215006, China.
FAU - Liu, Sanjiao
AU  - Liu S
AD  - Department of Neurology, The First Affiliated Hospital of Soochow University, No. 
      899 Pinghai Road, Suzhou, Jiangsu 215006, China.
FAU - Fang, Qi
AU  - Fang Q
AUID- ORCID: 0000-0002-9762-2687
AD  - Department of Neurology, The First Affiliated Hospital of Soochow University, No. 
      899 Pinghai Road, Suzhou, Jiangsu 215006, China.
FAU - Cai, Xiuying
AU  - Cai X
AUID- ORCID: 0000-0002-3496-3281
AD  - Department of Neurology, The First Affiliated Hospital of Soochow University, No. 
      899 Pinghai Road, Suzhou, Jiangsu 215006, China.
LA  - eng
PT  - Journal Article
DEP - 20200207
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
SB  - IM
MH  - Cerebral Small Vessel Diseases/*epidemiology/*etiology
MH  - Cost of Illness
MH  - Female
MH  - Humans
MH  - Hypertension/*complications
MH  - Male
MH  - Risk Factors
PMC - PMC7029257
COIS- The authors have no conflicts of interest.
EDAT- 2020/02/25 06:00
MHDA- 2020/11/25 06:00
PMCR- 2020/02/07
CRDT- 2020/02/25 06:00
PHST- 2019/08/24 00:00 [received]
PHST- 2019/12/08 00:00 [revised]
PHST- 2019/12/26 00:00 [accepted]
PHST- 2020/02/25 06:00 [entrez]
PHST- 2020/02/25 06:00 [pubmed]
PHST- 2020/11/25 06:00 [medline]
PHST- 2020/02/07 00:00 [pmc-release]
AID - 10.1155/2020/6498903 [doi]
PST - epublish
SO  - Biomed Res Int. 2020 Feb 7;2020:6498903. doi: 10.1155/2020/6498903. eCollection 
      2020.