PMID- 32090637
OWN - NLM
STAT- MEDLINE
DCOM- 20201127
LR  - 20210423
IS  - 1521-0464 (Electronic)
IS  - 1071-7544 (Print)
IS  - 1071-7544 (Linking)
VI  - 27
IP  - 1
DP  - 2020 Dec
TI  - Bicomponent polymeric micelles for pH-controlled delivery of doxorubicin.
PG  - 344-357
LID - 10.1080/10717544.2020.1726526 [doi]
AB  - Stimuli-responsive drug delivery systems (DDSs) are expected to realize 
      site-specific drug release and kill cancer cells selectively. In this study, a 
      pH-responsive micelle was designed utilizing the pH-sensitivity of borate bonds 
      formed between dopamine and boronic acid. First, methyl (polyethylene 
      glycol)-block-polycaprolactone (mPEG-PCL) was conjugated with 
      4-cyano-4-(thiobenzoylthio)pentanoic acid (CTP) to obtain a macroinitiator. Two 
      different segments poly(dopamine methacrylamide) (PDMA) and 
      poly(vinylphenylboronic acid) (PVBA) were then grafted to the end of mPEG-PCL. 
      Two triblock copolymers, mPEG-PCL-PDMA and mPEG-PCL-PVBA, were then obtained by 
      reversible addition-fragmentation transfer (RAFT) polymerization. These 
      copolymers and their mixture self-assembled in aqueous solution to form micelles 
      that were able to load hydrophobic anticancer drug doxorubicin (DOX). These 
      two-component micelles were found to be pH-sensitive, in contrast to the 
      one-component micelles. Furthermore, MTT studies showed that the micelles were 
      almost nontoxic. The DOX-loaded micelles showed cytotoxicity equivalent to that 
      of DOX at high concentration. In vivo antitumor experiments showed that this 
      pH-sensitive polymeric micellar system had an enhanced therapeutic effect on 
      tumors. These two-component boronate-based pH micelles are universally applicable 
      to the delivery of anticancer drugs, showing great potential for cancer therapy.
FAU - Wang, Chunyun
AU  - Wang C
AD  - Institute of Pharmacy, School of Pharmacy, Henan University, Kaifeng, China.
FAU - Qi, Peilan
AU  - Qi P
AD  - Institute of Pharmacy, School of Pharmacy, Henan University, Kaifeng, China.
FAU - Lu, Yan
AU  - Lu Y
AD  - Institute of Pharmacy, School of Pharmacy, Henan University, Kaifeng, China.
FAU - Liu, Lei
AU  - Liu L
AD  - Institute of Pharmacy, School of Pharmacy, Henan University, Kaifeng, China.
FAU - Zhang, Yanan
AU  - Zhang Y
AD  - Institute of Pharmacy, School of Pharmacy, Henan University, Kaifeng, China.
FAU - Sheng, Qianli
AU  - Sheng Q
AD  - Institute of Pharmacy, School of Pharmacy, Henan University, Kaifeng, China.
FAU - Wang, Tianshun
AU  - Wang T
AD  - Institute of Pharmacy, School of Pharmacy, Henan University, Kaifeng, China.
FAU - Zhang, Mengying
AU  - Zhang M
AD  - Institute of Pharmacy, School of Pharmacy, Henan University, Kaifeng, China.
FAU - Wang, Rui
AU  - Wang R
AD  - Institute of Pharmacy, School of Pharmacy, Henan University, Kaifeng, China.
FAU - Song, Shiyong
AU  - Song S
AUID- ORCID: 0000-0003-2208-608X
AD  - Institute of Pharmacy, School of Pharmacy, Henan University, Kaifeng, China.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Drug Deliv
JT  - Drug delivery
JID - 9417471
RN  - 0 (Antibiotics, Antineoplastic)
RN  - 0 (Boronic Acids)
RN  - 0 (Drug Carriers)
RN  - 0 (Micelles)
RN  - 0 (Polymers)
RN  - 80168379AG (Doxorubicin)
SB  - IM
MH  - Animals
MH  - Antibiotics, Antineoplastic/*administration & dosage/chemistry/pharmacology
MH  - Boronic Acids/chemistry
MH  - Doxorubicin/*administration & dosage/chemistry/pharmacology
MH  - Drug Carriers/chemistry
MH  - *Drug Delivery Systems
MH  - Drug Liberation
MH  - Female
MH  - Humans
MH  - Hydrogen-Ion Concentration
MH  - Mice
MH  - Micelles
MH  - Neoplasms/drug therapy
MH  - Polymers/*chemistry
MH  - Xenograft Model Antitumor Assays
PMC - PMC7054969
OTO - NOTNLM
OT  - Drug delivery
OT  - boronate ester
OT  - cancer
OT  - micelle
OT  - pH-responsive
EDAT- 2020/02/25 06:00
MHDA- 2020/11/28 06:00
PMCR- 2020/02/24
CRDT- 2020/02/25 06:00
PHST- 2020/02/25 06:00 [entrez]
PHST- 2020/02/25 06:00 [pubmed]
PHST- 2020/11/28 06:00 [medline]
PHST- 2020/02/24 00:00 [pmc-release]
AID - 1726526 [pii]
AID - 10.1080/10717544.2020.1726526 [doi]
PST - ppublish
SO  - Drug Deliv. 2020 Dec;27(1):344-357. doi: 10.1080/10717544.2020.1726526.