PMID- 3209069
OWN - NLM
STAT- MEDLINE
DCOM- 19890223
LR  - 20190516
IS  - 0890-9369 (Print)
IS  - 0890-9369 (Linking)
VI  - 2
IP  - 11
DP  - 1988 Nov
TI  - A group of genes required for pattern formation in the ventral ectoderm of the 
      Drosophila embryo.
PG  - 1496-511
AB  - Mutations in the genes spitz (spi), Star (S), single-minded (sim), pointed (pnt), 
      rhomboid (rho) (all zygotic), and sichel (sic) (maternal), collectively called 
      the spitz group, cause similar pattern alterations in ventral ectodermal 
      derivatives of the Drosophila embryo. The cuticle structures lacking in mutant 
      embryos normally derive from longitudinal strips of the ventro-lateral 
      blastoderm. Defects were found in the median part of the central nervous system 
      in whole-mount embryos stained with anti-HRP (horseradish peroxidase) antibodies. 
      In addition, the nerve cells expressing the even-skipped protein appeared 
      abnormally arranged. These results suggest that groups of cells from the same 
      region, including both epidermal and neural precursor cells, require spitz-group 
      gene activity for normal development. The members of the spitz group differ from 
      one another: sim affects a more median strip of the ventral ectoderm than the 
      other zygotic genes and pnt causes separation rather than deletion of pattern 
      elements. As shown by pole cell transplantations, spi and S are also required for 
      normal development of the female germ line, while sim, rho, and pnt appear to be 
      exclusively zygotically expressed, and the maternal gene sic acts in the germ 
      line autonomously. Some embryos produced by sic-homozygous females differentiate 
      the spitz phenotype, others develop normally or die early. Of all the spitz-group 
      genes, sim appears to have the most specific effect on the embryonic pattern. The 
      significance of the spitz-group phenotypes for the dorso-ventral pattern 
      formation is discussed.
FAU - Mayer, U
AU  - Mayer U
AD  - Max Planck Institut fur Entwicklungsbiologie, Tubingen, FRG.
FAU - Nusslein-Volhard, C
AU  - Nusslein-Volhard C
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Genes Dev
JT  - Genes & development
JID - 8711660
SB  - IM
MH  - Animals
MH  - Cell Differentiation
MH  - Central Nervous System/embryology
MH  - Drosophila/embryology/*genetics
MH  - Ectoderm/*cytology
MH  - Embryo, Nonmammalian
MH  - Female
MH  - *Genes
MH  - Mutation
MH  - Peripheral Nerves/embryology
MH  - Phenotype
EDAT- 1988/11/01 00:00
MHDA- 1988/11/01 00:01
CRDT- 1988/11/01 00:00
PHST- 1988/11/01 00:00 [pubmed]
PHST- 1988/11/01 00:01 [medline]
PHST- 1988/11/01 00:00 [entrez]
AID - 10.1101/gad.2.11.1496 [doi]
PST - ppublish
SO  - Genes Dev. 1988 Nov;2(11):1496-511. doi: 10.1101/gad.2.11.1496.