PMID- 32091451
OWN - NLM
STAT- MEDLINE
DCOM- 20211125
LR  - 20230927
IS  - 1536-7355 (Electronic)
IS  - 1076-1608 (Linking)
VI  - 27
IP  - 8
DP  - 2021 Dec 1
TI  - Measuring Choroid Thickness as a Marker of Systemic Inflammation in Patients With 
      Ankylosing Spondylitis.
PG  - e307-e311
LID - 10.1097/RHU.0000000000001348 [doi]
AB  - BACKGROUND AND OBJECTIVE: Ankylosing spondylitis (AS) is an inflammatory disease, 
      and choroidal thickness (CT) has been proposed and evaluated as a potential 
      marker of systemic inflammation associated with AS and other inflammatory 
      diseases. This study compared CT measurements taken from patients with severe AS 
      disease activity without eye inflammation with those taken from healthy subjects. 
      METHODS: This cross-sectional, multicenter study compared CT in 44 patients with 
      high AS disease activity, and no history of eye inflammation with CT in 44 
      matched healthy subjects aged between 18 and 65 years. In the AS group, the 
      correlation between CT and C-reactive protein, human leukocyte antigen (HLA) B27 
      positivity, disease duration, and disease activity was calculated. RESULTS: Mean 
      CT values of patients with AS were significantly higher in the right eye, the 
      left eye, and the thickest choroid eye. The right eye mean CT was 338.3 +/- 82.8 mum 
      among patients with AS and 290.5 +/- 71.2 mum among healthy subjects (p = 0.005). 
      The left eye mean CT was 339.5 +/- 84.7 mum for patients with AS and 298.4 +/- 68.9 mum 
      for healthy subjects (P = 0.015). The thickest choroid eye CT was 358.4 +/- 82.1 mum 
      among patients with AS and 314.1 +/- 65.2 mum among healthy subjects (P = 0.006). We 
      did not find a significant correlation between CT and disease activity, 
      C-reactive protein, human leukocyte antigen B27 positivity, or disease duration. 
      CONCLUSIONS: Patients with active AS but without a history of eye inflammation 
      had a thicker choroid than healthy subjects. This finding suggests that CT is a 
      marker of systemic inflammation in patients with inflammatory disease, regardless 
      of known eye symptoms.
CI  - Copyright (c) 2021 Wolters Kluwer Health, Inc. All rights reserved.
FAU - Steiner, Martina
AU  - Steiner M
FAU - Del Mar Esteban-Ortega, Maria
AU  - Del Mar Esteban-Ortega M
FAU - Thuissard-Vasallo, Israel
AU  - Thuissard-Vasallo I
AD  - School of Doctoral Studies and Research, Universidad Europea.
FAU - Garcia-Lozano, Isabel
AU  - Garcia-Lozano I
AD  - Department of Ophthalmology, Hospital Universitario Infanta Sofia.
FAU - Moriche-Carretero, Manuel
AU  - Moriche-Carretero M
FAU - Garcia-Gonzalez, Alejandro Javier
AU  - Garcia-Gonzalez AJ
AD  - Departments of Rheumatology.
FAU - Perez-Blazquez, Eugenio
AU  - Perez-Blazquez E
AD  - Ophthalmology, Hospital Universitario 12 de Octubre, Madrid.
FAU - Sambricio, Javier
AU  - Sambricio J
AD  - Ophthalmology, Hospital Universitario 12 de Octubre, Madrid.
FAU - Garcia-Aparicio, Angel
AU  - Garcia-Aparicio A
AD  - Departments of Rheumatology.
FAU - Casco-Silva, Bruno Francisco
AU  - Casco-Silva BF
AD  - Ophthalmology, Hospital Virgen de la Salud, Toledo.
FAU - Sanz-Sanz, Jesus
AU  - Sanz-Sanz J
AD  - Departments of Rheumatology.
FAU - Valdes-Sanz, Nuria
AU  - Valdes-Sanz N
AD  - Ophthalmology, Hospital Universitario de Majadahonda.
FAU - Fernandez-Espartero, Cruz
AU  - Fernandez-Espartero C
AD  - Departments of Rheumatology.
FAU - Diaz-Valle, Teresa
AU  - Diaz-Valle T
AD  - Ophthalmology, Hospital Universitario de Mostoles, Madrid.
FAU - Gurrea-Almela, Maria
AU  - Gurrea-Almela M
AD  - Ophthalmology, Hospital Universitario de Mostoles, Madrid.
FAU - Fernandez-Melon, Julia
AU  - Fernandez-Melon J
AD  - Departments of Rheumatology.
FAU - Gomez-Resa, Maria
AU  - Gomez-Resa M
AD  - Ophthalmology, Hospital Universitario Son Espases, Palma de Mallorca.
FAU - Pato-Cour, Esperanza
AU  - Pato-Cour E
AD  - Departments of Rheumatology.
FAU - Diaz-Valle, David
AU  - Diaz-Valle D
AD  - Ophthalmology, Hospital Clinico San Carlos.
FAU - Mendez-Fernandez, Rosalia
AU  - Mendez-Fernandez R
AD  - Ophthalmology, Hospital Clinico San Carlos.
FAU - Navio Marco, Teresa
AU  - Navio Marco T
AD  - Department of Rheumatology, Hospital Universitario Infanta Leonor.
FAU - Almodovar, Raquel
AU  - Almodovar R
AD  - Departments of Rheumatology.
FAU - Garcia-Saenz, Maria Carmen
AU  - Garcia-Saenz MC
AD  - Ophthalmology, Hospital Universitario Fundacion Alcorcon, Madrid, Spain.
FAU - Del-Prado-Sanchez, Cristina
AU  - Del-Prado-Sanchez C
AD  - Ophthalmology, Hospital Universitario Fundacion Alcorcon, Madrid, Spain.
FAU - Munoz-Fernandez, Santiago
AU  - Munoz-Fernandez S
CN  - Choroidal Thickness in Spondylitis (COnTEST) Study Group
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PL  - United States
TA  - J Clin Rheumatol
JT  - Journal of clinical rheumatology : practical reports on rheumatic & 
      musculoskeletal diseases
JID - 9518034
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Choroid/diagnostic imaging
MH  - Cross-Sectional Studies
MH  - Humans
MH  - Inflammation/diagnosis
MH  - Middle Aged
MH  - *Spondylitis, Ankylosing/complications/diagnosis
MH  - Tomography, Optical Coherence
MH  - Young Adult
COIS- Conflicts of interest and sources of funding: The present study is part of the 
      COnTEST Rheumatology and Ophthalmology Project. COnTEST received financial 
      support from the Madrid Rheumatologist Society (grant SORCOM/2017), Universidad 
      Europea (grant 2017/UEM12), and the Spanish Rheumatologist Foundation (grant FER 
      2017). The authors declare no conflict of interest.
EDAT- 2020/02/25 06:00
MHDA- 2021/11/26 06:00
CRDT- 2020/02/25 06:00
PHST- 2020/02/25 06:00 [pubmed]
PHST- 2021/11/26 06:00 [medline]
PHST- 2020/02/25 06:00 [entrez]
AID - 00124743-202112000-00009 [pii]
AID - 10.1097/RHU.0000000000001348 [doi]
PST - ppublish
SO  - J Clin Rheumatol. 2021 Dec 1;27(8):e307-e311. doi: 10.1097/RHU.0000000000001348.