PMID- 32093765
OWN - NLM
STAT- MEDLINE
DCOM- 20201123
LR  - 20221207
IS  - 1756-0500 (Electronic)
IS  - 1756-0500 (Linking)
VI  - 13
IP  - 1
DP  - 2020 Feb 24
TI  - The association between the rs4987105 of 5-lipoxygenase (ALOX5) gene and 
      gestational glucose metabolism in Chinese population.
PG  - 102
LID - 10.1186/s13104-020-04953-2 [doi]
LID - 102
AB  - OBJECTIVE: The arachidonate 5-lipoxygenase (ALOX5) pathway has been investigated 
      in diverse chronic inflammatory diseases including metabolic disorders. Recently, 
      the ALOX5 polymorphism rs4987105 was identified to confer susceptibility to type 
      2 diabetes mellitus (T2DM), implicating its role in regulating glucose 
      homeostasis. Gestational diabetes mellitus (GDM) shares similar pathogenic 
      mechanism with T2DM. Thus, we aimed to evaluate the association between rs4987105 
      and gestational glucose metabolism in Chinese pregnant women. RESULTS: A total of 
      380 unrelated Chinese pregnant women including 241 GDM patients and 139 controls 
      were included in this study. The genotypes of rs4987105 were examined by the 
      Agena MassARRAY iPLEX platform, the association between rs4987105 and fasting 
      plasma glucose (FPG) levels at 24-28 gestational weeks was evaluated using 
      different statistical methods. We found that carriers of rs4987105 CT/TT 
      genotypes exhibited significantly lower FPG levels (P = 0.011). In addition, we 
      observed a significant association between rs4987105 and FPG levels after 
      adjusting confounding variables in the linear regression analysis using dominant 
      genetic model (b = - 0.218; P = 0.01). The present study for the first time 
      reported that the rs4987105 of 5-lipoxygenase (ALOX5) gene was associated with 
      gestational glucose metabolism in Chinese pregnant women.
FAU - Li, Xi
AU  - Li X
AUID- ORCID: 0000-0002-8209-3751
AD  - Laboratory of Medical Genetics, Shenzhen Health Development Research Center, 4009 
      Xinzhou Road, Futian District, Shenzhen, 518040, China.
FAU - Su, Jindi
AU  - Su J
AD  - Laboratory of Medical Genetics, Shenzhen Health Development Research Center, 4009 
      Xinzhou Road, Futian District, Shenzhen, 518040, China.
FAU - Chen, Shiguo
AU  - Chen S
AD  - Laboratory of Medical Genetics, Shenzhen Health Development Research Center, 4009 
      Xinzhou Road, Futian District, Shenzhen, 518040, China.
FAU - Lin, Sheng
AU  - Lin S
AD  - Laboratory of Medical Genetics, Shenzhen Health Development Research Center, 4009 
      Xinzhou Road, Futian District, Shenzhen, 518040, China.
FAU - Zheng, Xiujie
AU  - Zheng X
AD  - Laboratory of Medical Genetics, Shenzhen Health Development Research Center, 4009 
      Xinzhou Road, Futian District, Shenzhen, 518040, China.
FAU - Wang, Baojiang
AU  - Wang B
AD  - Laboratory of Medical Genetics, Shenzhen Health Development Research Center, 4009 
      Xinzhou Road, Futian District, Shenzhen, 518040, China.
FAU - Yao, Keqin
AU  - Yao K
AD  - Laboratory of Medical Genetics, Shenzhen Health Development Research Center, 4009 
      Xinzhou Road, Futian District, Shenzhen, 518040, China.
FAU - Lai, Liping
AU  - Lai L
AD  - Endocrine Department, Futian Center for Chronic Disease Control, 9 Xinsha Road, 
      Futian District, Shenzhen, China.
FAU - Duan, Shan
AU  - Duan S
AD  - Laboratory of Medical Genetics, Shenzhen Health Development Research Center, 4009 
      Xinzhou Road, Futian District, Shenzhen, 518040, China. szippl@163.com.
LA  - eng
GR  - JCYJ20170307160056430/Shenzhen Science and Technology Committee/
PT  - Journal Article
DEP - 20200224
PL  - England
TA  - BMC Res Notes
JT  - BMC research notes
JID - 101462768
RN  - 0 (Blood Glucose)
RN  - EC 1.13.11.34 (Arachidonate 5-Lipoxygenase)
RN  - EC 1.3.11.34 (ALOX5 protein, human)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Arachidonate 5-Lipoxygenase/*genetics
MH  - Asian People/genetics
MH  - Blood Glucose/*metabolism
MH  - China
MH  - Diabetes, Gestational/blood/ethnology/*genetics
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease/ethnology/*genetics
MH  - Genotype
MH  - Glucose/*metabolism
MH  - Humans
MH  - *Polymorphism, Single Nucleotide
MH  - Pregnancy
MH  - Risk Factors
PMC - PMC7041080
OTO - NOTNLM
OT  - ALOX5
OT  - Fasting plasma glucose
OT  - Genetic susceptibility
OT  - Gestational diabetes mellitus
OT  - Polymorphism
COIS- The authors declare that they have no competing interests.
EDAT- 2020/02/26 06:00
MHDA- 2020/11/24 06:00
PMCR- 2020/02/24
CRDT- 2020/02/26 06:00
PHST- 2020/01/05 00:00 [received]
PHST- 2020/02/12 00:00 [accepted]
PHST- 2020/02/26 06:00 [entrez]
PHST- 2020/02/26 06:00 [pubmed]
PHST- 2020/11/24 06:00 [medline]
PHST- 2020/02/24 00:00 [pmc-release]
AID - 10.1186/s13104-020-04953-2 [pii]
AID - 4953 [pii]
AID - 10.1186/s13104-020-04953-2 [doi]
PST - epublish
SO  - BMC Res Notes. 2020 Feb 24;13(1):102. doi: 10.1186/s13104-020-04953-2.