PMID- 32095145
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240328
IS  - 1735-5303 (Print)
IS  - 2345-3656 (Electronic)
IS  - 1735-5303 (Linking)
VI  - 15
IP  - 1
DP  - 2020 Winter
TI  - Can the Decreased Expression of Human Leukocyte Antigen Class Ⅰ and Ⅱ by 
      Spermatozoa Lead to Recurrent Spontaneous Abortion?
PG  - 19-22
LID - 10.30699/IJP.2019.102943.2026 [doi]
AB  - BACKGROUND & OBJECTIVE: Unexplained recurrent spontaneous abortion (URSA) is 
      defined as an unknown cause of occurrence of three or more clinically detectable 
      pregnancy losses before 20 weeks of gestation, but it occurs presumably as a 
      result of the immune system dysfunctions. We supposed that the disruption of 
      semen or spermatozoa might be responsible for the dysfunction of the immune 
      system in women with URSA. Semen and spermatozoa (as antigens) induce female 
      reproductive tract (FRT) immunity. This stimulated immunity is necessary for 
      pregnancy occurrence. The disruption of semen or spermatozoa can be a result of 
      altering a variety of surface molecules on spermatozoa, especially polymorphic 
      human leukocyte antigen (HLA) molecules or antigens. Despite the importance of 
      HLA antigens in reproduction, to the best of our knowledge, no one has studied 
      the relation of HLA expression between spermatozoa and URSA. Therefore, this 
      paper aims to assess this relation. METHODS: Semen samples were collected from 15 
      URSA couples and 20 normal couples. After purification of normal spermatozoa, the 
      HLA class I and II expressions were evaluated by flow cytometry methods. RESULTS: 
      Results showed that the expression of both HLA class I and II by spermatozoa, in 
      URSA couples, was significantly less than the control couples. CONCLUSION: The 
      decreased expression of polymorphic HLA class Ⅰ and Ⅱ by spermatozoa can be 
      related to URSA occurrence.
CI  - (c) 2020.
FAU - Sereshki, Nasrin
AU  - Sereshki N
AD  - Department of Immunology, School of Medicine, Isfahan University of Medical 
      Sciences, Isfahan, Iran.
FAU - Andalib, Alireza
AU  - Andalib A
AD  - Department of Immunology, School of Medicine, Isfahan University of Medical 
      Sciences, Isfahan, Iran.
FAU - Ghahiri, Ataollah
AU  - Ghahiri A
AD  - Department of Obstetrics and Gynecology, Al-Zahra Hospital, Isfahan University of 
      Medical Sciences, Isfahan, Iran.
FAU - Mehrabian, Ferdos
AU  - Mehrabian F
AD  - Department of Obstetrics and Gynecology, Al-Zahra Hospital, Isfahan University of 
      Medical Sciences, Isfahan, Iran.
FAU - Sherkat, Roya
AU  - Sherkat R
AD  - Department of Obstetrics and Gynecology, Al-Zahra Hospital, Isfahan University of 
      Medical Sciences, Isfahan, Iran.
FAU - Rezaei, Abbas
AU  - Rezaei A
AD  - Department of Immunology, School of Medicine, Isfahan University of Medical 
      Sciences, Isfahan, Iran.
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - Iran J Pathol
JT  - Iranian journal of pathology
JID - 101515128
PMC - PMC6995681
OTO - NOTNLM
OT  - Polymorphic HLA class Ⅰ and Ⅱ
OT  - Spermatozoa
OT  - Unexplained recurrent spontaneous abortion
COIS- The authors declared that there is no conflict of interest regarding the 
      publication of this article.
EDAT- 2020/02/26 06:00
MHDA- 2020/02/26 06:01
PMCR- 2020/01/01
CRDT- 2020/02/26 06:00
PHST- 2020/02/26 06:00 [entrez]
PHST- 2020/02/26 06:00 [pubmed]
PHST- 2020/02/26 06:01 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - 10.30699/IJP.2019.102943.2026 [doi]
PST - ppublish
SO  - Iran J Pathol. 2020 Winter;15(1):19-22. doi: 10.30699/IJP.2019.102943.2026.