PMID- 32096665
OWN - NLM
STAT- MEDLINE
DCOM- 20210408
LR  - 20210408
IS  - 1097-9867 (Electronic)
IS  - 1083-7450 (Linking)
VI  - 25
IP  - 7
DP  - 2020 Sep
TI  - Deep eutectic solvents for pharmaceutical formulation and drug delivery 
      applications.
PG  - 779-796
LID - 10.1080/10837450.2020.1735414 [doi]
AB  - Solvents play key roles in designing drug delivery systems (DDSs). They are used 
      as the reaction media in the preparation of DDSs and as vehicles for delivery of 
      problematic drugs. The number of pharmaceutically acceptable solvents is limited 
      and developing new green ones is of a great of interest. A deep eutectic solvent 
      (DES) is a room temperature liquid composed of a mixture of hydrogen bond 
      acceptor and hydrogen bond donor. DESs exhibit interesting physical and chemical 
      characteristics such as low vapor pressure, non-inflammability, chemically 
      tailorable, solvency power for a wide range of solutes, and water non-reactivity. 
      Furthermore, they can be easily prepared from low toxicity, readily available, 
      and inexpensive constituents. Due to these properties, DESs have attracted 
      growing attention as green solvents in different areas of science from chemistry 
      to material engineering and biology. In this review, after a brief introduction 
      about DESs, we provide an overview about current advances made over the last 
      decade in utilizing of DESs for solubilization of water insoluble drugs, 
      transdermal drug delivery, inorganic nanoparticle synthesis, and designing 
      polymeric and self-assembled drug carriers. This paper also discusses main 
      challenges and limitations of DESs that should be considered before using of 
      them.
FAU - Emami, Shahram
AU  - Emami S
AUID- ORCID: 0000-0002-5182-1728
AD  - Department of Pharmaceutics, School of Pharmacy, Urmia University of Medical 
      Sciences, Urmia, Iran.
FAU - Shayanfar, Ali
AU  - Shayanfar A
AUID- ORCID: 0000-0001-7507-9057
AD  - Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz 
      University of Medical Sciences, Tabriz, Iran.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20200309
PL  - England
TA  - Pharm Dev Technol
JT  - Pharmaceutical development and technology
JID - 9610932
RN  - 0 (Drug Carriers)
RN  - 0 (Pharmaceutical Preparations)
RN  - 0 (Solvents)
SB  - IM
MH  - Animals
MH  - Drug Carriers/administration & dosage/chemical synthesis
MH  - Drug Compounding/*methods
MH  - Drug Delivery Systems/*methods
MH  - Humans
MH  - Pharmaceutical Preparations/administration & dosage/*chemical synthesis
MH  - Solubility
MH  - Solvents/administration & dosage/*chemical synthesis
OTO - NOTNLM
OT  - Deep eutectic solvents
OT  - active pharmaceutical ingredient
OT  - drug delivery
OT  - nanomaterials
OT  - self-assembly
OT  - solubility
OT  - toxicity
EDAT- 2020/02/26 06:00
MHDA- 2021/04/10 06:00
CRDT- 2020/02/26 06:00
PHST- 2020/02/26 06:00 [pubmed]
PHST- 2021/04/10 06:00 [medline]
PHST- 2020/02/26 06:00 [entrez]
AID - 10.1080/10837450.2020.1735414 [doi]
PST - ppublish
SO  - Pharm Dev Technol. 2020 Sep;25(7):779-796. doi: 10.1080/10837450.2020.1735414. 
      Epub 2020 Mar 9.