PMID- 32097543
OWN - NLM
STAT- MEDLINE
DCOM- 20210317
LR  - 20210317
IS  - 2162-3279 (Electronic)
VI  - 10
IP  - 4
DP  - 2020 Apr
TI  - Changes in mean platelet volume and hematologic indices in patients with panic 
      disorder due to oxidative stress.
PG  - e01569
LID - 10.1002/brb3.1569 [doi]
LID - e01569
AB  - OBJECTIVE: Cardiovascular disorders are common in patients with panic disorder 
      (PD), usually mediated by platelets. The present study was conducted to evaluate 
      oxidative stress conditions and complete analysis of blood cells in patients with 
      PD. SETTING AND SAMPLE POPULATION: Sixty healthy individuals and 60 patients were 
      included in the study. Whole blood and serum samples were obtained from patients 
      and controls. MATERIALS & METHOD: Hematological studies, including blood cells 
      count, hemoglobin, and hematocrit, were carried out on whole blood samples. In 
      addition, oxidative stress indices including total antioxidant capacity, free 
      oxygen species, and malondialdehyde concentration were measured in serum samples. 
      RESULTS: Results showed that patients with PD had a significant increase in mean 
      platelet volume index (MPV), platelet distribution width (PDW), red blood cell 
      distribution width (RDW), and mean corpuscular hemoglobin concentration (MCHC) 
      compared with healthy subjects (p < .05). Also, oxidative stress indices were 
      significantly elevated in patients with PD compared with control group (p < .05). 
      CONCLUSION: Elevated MPV is a hematologic indicator for patients with PD. This 
      disorder may be caused by impaired serotonin metabolism, resulting in increased 
      oxidative stress, as well as in platelet serotonin transporters. Regarding 
      elevated oxidative stress, the risk of cardiovascular complications is high in 
      patients with PD.
CI  - (c) 2020 The Authors. Brain and Behavior published by Wiley Periodicals, Inc.
FAU - Naghipour Hamzekolaei, Maryam
AU  - Naghipour Hamzekolaei M
AD  - Veterinary School, Orumiyeh University, Orumiyeh, Iran.
FAU - Jafarisani, Moslem
AU  - Jafarisani M
AUID- ORCID: 0000-0002-8341-6049
AD  - Clinical Biochemistry, School of Medicine, Shahroud University of Medical 
      Sciences, Shahroud, Iran.
FAU - Farajzadeh, Asghar
AU  - Farajzadeh A
AD  - Department of Clinical Laboratory Sciences, Ardabil Branch, Islamic Azad 
      University, Ardabil, Iran.
FAU - Aghayan, Seyed Shahrokh
AU  - Aghayan SS
AD  - School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran.
FAU - Atashi, Amir
AU  - Atashi A
AD  - Department of Hematology, School of Allied Medicine, Shahroud University of 
      Medical Sciences, Shahroud, Iran.
FAU - Yarmohammadi, Maryam
AU  - Yarmohammadi M
AD  - School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran.
FAU - Sadeghi, Iman
AU  - Sadeghi I
AD  - Genetic, Ceinge Biotechnologia Avanzate, Napl, Italy.
FAU - Tashakori, Mersedeh
AU  - Tashakori M
AD  - Department of Biology, Science and Research Branch, Islamic Azad University, 
      Tehran, Iran.
LA  - eng
GR  - 9751/Shahroud University of Medical Sciences/International
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200225
PL  - United States
TA  - Brain Behav
JT  - Brain and behavior
JID - 101570837
RN  - 0 (Hemoglobins)
SB  - IM
MH  - Adult
MH  - Blood Platelets/metabolism
MH  - Case-Control Studies
MH  - Erythrocyte Indices
MH  - Female
MH  - Hematocrit
MH  - Hemoglobins/*analysis
MH  - Humans
MH  - Male
MH  - Mean Platelet Volume
MH  - Middle Aged
MH  - Oxidative Stress/*physiology
MH  - Panic Disorder/blood/*metabolism
MH  - Young Adult
PMC - PMC7177570
OTO - NOTNLM
OT  - MCHC
OT  - MPV
OT  - RDW
OT  - oxidative stress
OT  - panic disorder
COIS- None declared.
EDAT- 2020/02/26 06:00
MHDA- 2021/03/18 06:00
PMCR- 2020/02/25
CRDT- 2020/02/26 06:00
PHST- 2019/10/20 00:00 [received]
PHST- 2020/01/11 00:00 [revised]
PHST- 2020/01/27 00:00 [accepted]
PHST- 2020/02/26 06:00 [pubmed]
PHST- 2021/03/18 06:00 [medline]
PHST- 2020/02/26 06:00 [entrez]
PHST- 2020/02/25 00:00 [pmc-release]
AID - BRB31569 [pii]
AID - 10.1002/brb3.1569 [doi]
PST - ppublish
SO  - Brain Behav. 2020 Apr;10(4):e01569. doi: 10.1002/brb3.1569. Epub 2020 Feb 25.