PMID- 32098546
OWN - NLM
STAT- MEDLINE
DCOM- 20210219
LR  - 20210219
IS  - 1747-6356 (Electronic)
IS  - 1747-6348 (Linking)
VI  - 14
IP  - 5
DP  - 2020 May
TI  - Clinical relevance of understanding mitogen-activated protein kinases involved in 
      asthma.
PG  - 501-510
LID - 10.1080/17476348.2020.1735365 [doi]
AB  - Introduction: Mitogen-activated protein kinases (MAPKs) are a large family of 
      evolutionary conserved intracellular enzymes that play a pivotal role in 
      signaling pathways mediating the biologic actions of a wide array of 
      extracellular stimuli.Areas covered: MAPKs are implicated in most pathogenic 
      events involved in asthma, including both inflammatory and structural changes 
      occurring in the airways. Indeed, MAPKs are located at the level of crucial 
      convergence points within the signal transduction networks activated by many 
      cytokines, chemokines, growth factors, and other inducers of bronchial 
      inflammation and remodeling such as immunoglobulin E (IgE) and oxidative 
      stress.Expert opinion: Therefore, given the growing importance of MAPKs in asthma 
      pathobiology, these signaling enzymes are emerging as key intracellular pathways 
      whose upstream activation can be inhibited by biological drugs such as 
      anti-cytokines and anti-IgE.
FAU - Pelaia, Corrado
AU  - Pelaia C
AD  - Department of Medical and Surgical Sciences, University "Magna Graecia" of 
      Catanzaro, Catanzaro, Italy.
FAU - Vatrella, Alessandro
AU  - Vatrella A
AD  - Department of Medicine, Surgery and Dentistry, University of Salerno, Salerno, 
      Italy.
FAU - Crimi, Claudia
AU  - Crimi C
AUID- ORCID: 0000-0002-9088-5214
AD  - Department of Clinical and Experimental Medicine, University of Catania, Catania, 
      Italy.
FAU - Gallelli, Luca
AU  - Gallelli L
AD  - Department of Health Science, University "Magna Graecia" of Catanzaro, Catanzaro, 
      Italy.
FAU - Terracciano, Rosa
AU  - Terracciano R
AD  - Department of Health Science, University "Magna Graecia" of Catanzaro, Catanzaro, 
      Italy.
FAU - Pelaia, Girolamo
AU  - Pelaia G
AD  - Department of Medical and Surgical Sciences, University "Magna Graecia" of 
      Catanzaro, Catanzaro, Italy.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20200228
PL  - England
TA  - Expert Rev Respir Med
JT  - Expert review of respiratory medicine
JID - 101278196
RN  - 0 (Cytokines)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
SB  - IM
MH  - Asthma/*enzymology/immunology/metabolism
MH  - Bronchi/enzymology/metabolism
MH  - Cytokines/immunology
MH  - Humans
MH  - Mitogen-Activated Protein Kinases/*metabolism
MH  - Oxidative Stress
MH  - Signal Transduction
OTO - NOTNLM
OT  - Asthma
OT  - ERK
OT  - JNK
OT  - MAPK inhibitors
OT  - MAPKs
OT  - p38
EDAT- 2020/02/27 06:00
MHDA- 2021/02/20 06:00
CRDT- 2020/02/27 06:00
PHST- 2020/02/27 06:00 [pubmed]
PHST- 2021/02/20 06:00 [medline]
PHST- 2020/02/27 06:00 [entrez]
AID - 10.1080/17476348.2020.1735365 [doi]
PST - ppublish
SO  - Expert Rev Respir Med. 2020 May;14(5):501-510. doi: 
      10.1080/17476348.2020.1735365. Epub 2020 Feb 28.