PMID- 32098899
OWN - NLM
STAT- MEDLINE
DCOM- 20210107
LR  - 20210107
IS  - 2052-4897 (Electronic)
IS  - 2052-4897 (Linking)
VI  - 8
IP  - 1
DP  - 2020 Feb
TI  - Breakfast skipping is associated with persistently increased arterial stiffness 
      in patients with type 2 diabetes.
LID - 10.1136/bmjdrc-2019-001162 [doi]
LID - e001162
AB  - OBJECTIVE: While certain lifestyle habits may be associated with arterial 
      stiffness, there is limited literature investigating the relationship between 
      lifestyle habits and longitudinal changes in arterial stiffness in patients with 
      type 2 diabetes mellitus (T2DM). This is an exploratory study to determine 
      whether lifestyle habits, in addition to conventional atherosclerotic risk 
      factors, are associated with increased arterial stiffness. RESEARCH DESIGN AND 
      METHODS: The study participants comprised 734 Japanese outpatients with T2DM and 
      no history of apparent cardiovascular diseases. Lifestyle habits were analyzed 
      using self-reported questionnaires, and brachial-ankle pulse wave velocity 
      (baPWV) was measured at baseline, and at years 2 and 5. A multivariable linear 
      mixed-effects model was used to determine the predictive value of lifestyle 
      habits and possible atherosclerotic risk factors for longitudinal change in 
      baPWV. RESULTS: Over 5 years of follow-up, baPWV values significantly increased. 
      In a multivariable linear mixed-effects model that adjusted for age and gender, a 
      low frequency of breakfast intake was significantly associated with persistently 
      high baPWV, independently of other lifestyle habits. Furthermore, in a 
      multivariable linear mixed-effects model that included both lifestyle habits and 
      possible atherosclerotic risk factors, a low frequency of breakfast intake 
      remained the only independent predictive factor for persistently high baPWV. 
      Subjects who ate breakfast less frequently tended to have additional unhealthy 
      lifestyle habits and atherosclerotic risk factors. CONCLUSIONS: Our analyses 
      suggest that breakfast skipping is an independent lifestyle habit that is 
      associated with persistently increased arterial stiffness in patients with T2DM. 
      TRIAL REGISTRATION NUMBER: UMIN000010932.
CI  - (c) Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No 
      commercial re-use. See rights and permissions. Published by BMJ.
FAU - Mita, Tomoya
AU  - Mita T
AUID- ORCID: 0000-0002-4401-2965
AD  - Department of Metabolism & Endocrinology, Juntendo University Graduate School of 
      Medicine, Bunkyo-ku, Japan tom-m@juntendo.ac.jp.
AD  - Center for Molecular Diabetology, Juntendo University Graduate School of 
      Medicine, Tokyo, Japan.
FAU - Osonoi, Yusuke
AU  - Osonoi Y
AD  - Department of Metabolism & Endocrinology, Juntendo University Graduate School of 
      Medicine, Bunkyo-ku, Japan.
FAU - Osonoi, Takeshi
AU  - Osonoi T
AD  - Naka Kinen Clinic, Naka, Japan.
FAU - Saito, Miyoko
AU  - Saito M
AD  - Naka Kinen Clinic, Naka, Japan.
FAU - Nakayama, Shiho
AU  - Nakayama S
AD  - Department of Metabolism & Endocrinology, Juntendo University Graduate School of 
      Medicine, Bunkyo-ku, Japan.
FAU - Someya, Yuki
AU  - Someya Y
AD  - Department of Metabolism & Endocrinology, Juntendo University Graduate School of 
      Medicine, Bunkyo-ku, Japan.
FAU - Ishida, Hidenori
AU  - Ishida H
AD  - Naka Kinen Clinic, Naka, Japan.
FAU - Gosho, Masahiko
AU  - Gosho M
AD  - Department of Biostatistics, Faculty of Medicine, University of Tsukuba, Tsukuba, 
      Japan.
FAU - Watada, Hirotaka
AU  - Watada H
AD  - Department of Metabolism & Endocrinology, Juntendo University Graduate School of 
      Medicine, Bunkyo-ku, Japan.
AD  - Center for Molecular Diabetology, Juntendo University Graduate School of 
      Medicine, Tokyo, Japan.
AD  - Center for Therapeutic Innovations in Diabetes, Juntendo University Graduate 
      School of Medicine, Tokyo, Japan.
AD  - Sportology Center, Juntendo University Graduate School of Medicine, Tokyo, Japan.
LA  - eng
SI  - UMIN-CTR/UMIN000010932
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - BMJ Open Diabetes Res Care
JT  - BMJ open diabetes research & care
JID - 101641391
SB  - IM
MH  - Aged
MH  - Atherosclerosis/*epidemiology
MH  - *Breakfast
MH  - Cardio Ankle Vascular Index
MH  - Diabetes Mellitus, Type 2/*epidemiology
MH  - *Eating
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Japan/epidemiology
MH  - Life Style
MH  - Linear Models
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Risk Factors
MH  - Self Report
MH  - *Vascular Stiffness
PMC - PMC7206922
OTO - NOTNLM
OT  - arterial stiffness
OT  - breakfast skipping
OT  - conventional atherosclerotic risk factors
OT  - type 2 diabetes mellitus
COIS- Competing interests: None declared.
EDAT- 2020/02/27 06:00
MHDA- 2021/01/08 06:00
PMCR- 2020/02/24
CRDT- 2020/02/27 06:00
PHST- 2019/12/27 00:00 [received]
PHST- 2020/01/11 00:00 [revised]
PHST- 2020/01/28 00:00 [accepted]
PHST- 2020/02/27 06:00 [entrez]
PHST- 2020/02/27 06:00 [pubmed]
PHST- 2021/01/08 06:00 [medline]
PHST- 2020/02/24 00:00 [pmc-release]
AID - 8/1/e001162 [pii]
AID - bmjdrc-2019-001162 [pii]
AID - 10.1136/bmjdrc-2019-001162 [doi]
PST - ppublish
SO  - BMJ Open Diabetes Res Care. 2020 Feb;8(1):e001162. doi: 
      10.1136/bmjdrc-2019-001162.