PMID- 32100476
OWN - NLM
STAT- MEDLINE
DCOM- 20210709
LR  - 20210709
IS  - 2211-5463 (Electronic)
IS  - 2211-5463 (Linking)
VI  - 10
IP  - 5
DP  - 2020 May
TI  - Down-regulation of anti-inflammatory TIPE2 may aggravate adenoidal hypertrophy in 
      children.
PG  - 761-766
LID - 10.1002/2211-5463.12821 [doi]
AB  - Adenoidal hypertrophy (AH) is a common disorder in the pediatric population, with 
      common symptoms including mouth breathing, nasal congestion, hyponasal speech, 
      snoring and obstructive sleep apnea. Although the pathogenesis of AH has not been 
      fully elucidated, recent studies have indicated that immune responses may play an 
      important role in AH. Tumor necrosis factor-alpha (TNF-alpha)-induced protein-8 
      like-2 (TIPE2) is a newly identified protein that negatively regulates the 
      activation of inflammatory pathways. Here, we investigated the effect of TIPE2 in 
      AH in children. We observed that the levels of TNF-alpha and interleukin-6 were 
      greater in the adenoid tissue of AH children than in healthy control subjects 
      (P < 0.01), and this increase was positively correlated with the severity of AH. 
      The level of TIPE2 expression was decreased compared with control and was 
      negatively correlated with AH. TIPE2 overexpression in primary human monocytes 
      (isolated from adenoid tissue of children with AH) inhibited the activation of 
      nuclear factor-kappaB and the expression of TNF-alpha and interleukin-6. These results 
      suggest that overexpression of TIPE2 may attenuate AH through inactivation of the 
      nuclear factor-kappaB signaling pathway.
CI  - (c) 2020 The Authors. Published by FEBS Press and John Wiley & Sons Ltd.
FAU - Gao, Kun
AU  - Gao K
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, Shandong Provincial 
      Hospital affiliated to Shandong University, Jinan City, China.
FAU - Li, Yanzhong
AU  - Li Y
AD  - Department of Otorhinolaryngology, Qilu Hospital of Shandong University, NHC Key 
      Laboratory of Otorhinolaryngology (Shandong University), Jinan City, China.
FAU - Yue, Zhiyong
AU  - Yue Z
AUID- ORCID: 0000-0002-8085-3972
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, Shandong Provincial 
      Hospital affiliated to Shandong University, Jinan City, China.
FAU - Han, Jie
AU  - Han J
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, Shandong Provincial 
      Hospital affiliated to Shandong University, Jinan City, China.
FAU - Zhou, Xuanchen
AU  - Zhou X
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, Shandong Provincial 
      Hospital affiliated to Shandong University, Jinan City, China.
FAU - Wang, Xiaoting
AU  - Wang X
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, Shandong Provincial 
      Hospital affiliated to Shandong University, Jinan City, China.
LA  - eng
PT  - Journal Article
DEP - 20200322
PL  - England
TA  - FEBS Open Bio
JT  - FEBS open bio
JID - 101580716
RN  - 0 (Interleukin-6)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (TNFAIP8L2 protein, human)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adenoids/metabolism/*pathology
MH  - Child
MH  - Child, Preschool
MH  - China
MH  - Female
MH  - Humans
MH  - Hypertrophy/metabolism
MH  - Inflammation/immunology
MH  - Interleukin-6/metabolism
MH  - Intracellular Signaling Peptides and Proteins/genetics/*metabolism
MH  - Male
MH  - Monocytes/metabolism
MH  - RNA, Messenger/metabolism
MH  - Signal Transduction/genetics
MH  - Tumor Necrosis Factor-alpha/metabolism
PMC - PMC7193160
OTO - NOTNLM
OT  - IL-6
OT  - adenoidal hypertrophy
OT  - inflammation
OT  - tumor necrosis factor-alpha-induced protein-8 like-2
COIS- The authors declare no conflict of interest.
EDAT- 2020/02/27 06:00
MHDA- 2021/07/10 06:00
PMCR- 2020/03/22
CRDT- 2020/02/27 06:00
PHST- 2019/11/19 00:00 [received]
PHST- 2020/02/10 00:00 [revised]
PHST- 2020/02/24 00:00 [accepted]
PHST- 2020/02/27 06:00 [pubmed]
PHST- 2021/07/10 06:00 [medline]
PHST- 2020/02/27 06:00 [entrez]
PHST- 2020/03/22 00:00 [pmc-release]
AID - FEB412821 [pii]
AID - 10.1002/2211-5463.12821 [doi]
PST - ppublish
SO  - FEBS Open Bio. 2020 May;10(5):761-766. doi: 10.1002/2211-5463.12821. Epub 2020 
      Mar 22.