PMID- 32101698 OWN - NLM STAT- MEDLINE DCOM- 20200811 LR - 20211101 IS - 1097-4199 (Electronic) IS - 0896-6273 (Linking) VI - 106 IP - 2 DP - 2020 Apr 22 TI - Prefrontal Cortex Corticotropin-Releasing Factor Neurons Control Behavioral Style Selection under Challenging Situations. PG - 301-315.e7 LID - S0896-6273(20)30060-X [pii] LID - 10.1016/j.neuron.2020.01.033 [doi] AB - In response to stressors, individuals adopt different behavioral styles, which are essential for survival and form the basis of differential susceptibility to stress-related disorders. Corticotropin-releasing factor (CRF) and the medial prefrontal cortex (mPFC) have predominantly been studied in behavioral response to stress, while the role of mPFC CRF neurons is poorly understood. Using morphology, electrophysiology, and calcium imaging approaches, we characterized mPFC CRF neurons as a unique subtype of GABAergic inhibitory interneurons that were directly engaged in the tail suspension challenge. Genetic ablation or chemogenetic inhibition of dorsal mPFC (dmPFC) CRF neurons increased immobility under the tail-suspension and forced-swimming challenges and induced social avoidance behavior, whereas activation had the opposite effect on the same measures. Furthermore, increasing CRF neuronal activity promoted durable resilience to repeated social defeat stress. These results uncover a critical role of mPFC CRF interneurons in bidirectionally controlling motivated behavioral style selection under stress. CI - Copyright (c) 2020 Elsevier Inc. All rights reserved. FAU - Chen, Peng AU - Chen P AD - Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, Chinese Academy of Sciences Key Laboratory of Brain Function and Diseases, University of Science and Technology of China, Hefei 230026, China. FAU - Lou, Shihao AU - Lou S AD - Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, Chinese Academy of Sciences Key Laboratory of Brain Function and Diseases, University of Science and Technology of China, Hefei 230026, China. FAU - Huang, Zhao-Huan AU - Huang ZH AD - Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, Chinese Academy of Sciences Key Laboratory of Brain Function and Diseases, University of Science and Technology of China, Hefei 230026, China. FAU - Wang, Zhenni AU - Wang Z AD - Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, Chinese Academy of Sciences Key Laboratory of Brain Function and Diseases, University of Science and Technology of China, Hefei 230026, China. FAU - Shan, Qing-Hong AU - Shan QH AD - Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, Chinese Academy of Sciences Key Laboratory of Brain Function and Diseases, University of Science and Technology of China, Hefei 230026, China. FAU - Wang, Yu AU - Wang Y AD - Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, Chinese Academy of Sciences Key Laboratory of Brain Function and Diseases, University of Science and Technology of China, Hefei 230026, China. FAU - Yang, Yupeng AU - Yang Y AD - Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, Chinese Academy of Sciences Key Laboratory of Brain Function and Diseases, University of Science and Technology of China, Hefei 230026, China. FAU - Li, Xiangning AU - Li X AD - Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, School of Engineering Sciences, Key Laboratory of Biomedical Photonics of Ministry of Education, Huazhong University of Science and Technology, Wuhan 430074, China. FAU - Gong, Hui AU - Gong H AD - Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China; Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, School of Engineering Sciences, Key Laboratory of Biomedical Photonics of Ministry of Education, Huazhong University of Science and Technology, Wuhan 430074, China. FAU - Jin, Yan AU - Jin Y AD - Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, Chinese Academy of Sciences Key Laboratory of Brain Function and Diseases, University of Science and Technology of China, Hefei 230026, China. FAU - Zhang, Zhi AU - Zhang Z AD - Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, Chinese Academy of Sciences Key Laboratory of Brain Function and Diseases, University of Science and Technology of China, Hefei 230026, China. FAU - Zhou, Jiang-Ning AU - Zhou JN AD - Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, Chinese Academy of Sciences Key Laboratory of Brain Function and Diseases, University of Science and Technology of China, Hefei 230026, China; Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China. Electronic address: jnzhou@ustc.edu.cn. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20200225 PL - United States TA - Neuron JT - Neuron JID - 8809320 RN - 56-12-2 (gamma-Aminobutyric Acid) RN - 9015-71-8 (Corticotropin-Releasing Hormone) SB - IM CIN - J Neurophysiol. 2021 Feb 1;125(2):533-536. PMID: 33356874 MH - Animals MH - Avoidance Learning MH - Behavior, Animal/*physiology MH - Calcium Signaling MH - Corticotropin-Releasing Hormone/genetics/*physiology MH - Electrophysiological Phenomena MH - Hindlimb Suspension MH - Interneurons/physiology MH - Interpersonal Relations MH - Male MH - Mice MH - Mice, Knockout MH - Prefrontal Cortex/cytology/*physiology MH - Resilience, Psychological MH - Stress, Psychological/psychology MH - Swimming/psychology MH - gamma-Aminobutyric Acid/physiology OTO - NOTNLM OT - behavioral style selection OT - corticotropin-releasing factor neurons OT - prefrontal cortex OT - social defeat stress COIS- Declaration of Interests The authors declare no competing interests. EDAT- 2020/02/27 06:00 MHDA- 2020/08/12 06:00 CRDT- 2020/02/27 06:00 PHST- 2019/02/15 00:00 [received] PHST- 2019/10/31 00:00 [revised] PHST- 2020/01/24 00:00 [accepted] PHST- 2020/02/27 06:00 [pubmed] PHST- 2020/08/12 06:00 [medline] PHST- 2020/02/27 06:00 [entrez] AID - S0896-6273(20)30060-X [pii] AID - 10.1016/j.neuron.2020.01.033 [doi] PST - ppublish SO - Neuron. 2020 Apr 22;106(2):301-315.e7. doi: 10.1016/j.neuron.2020.01.033. Epub 2020 Feb 25.