PMID- 32101875
OWN - NLM
STAT- MEDLINE
DCOM- 20201104
LR  - 20201104
IS  - 1423-0143 (Electronic)
IS  - 1420-4096 (Linking)
VI  - 45
IP  - 2
DP  - 2020
TI  - Late Gadolinium Enhancement in Cardiac Magnetic Resonance Imaging Is Associated 
      with High Renal Resistive Index in Patients with Systemic Sclerosis.
PG  - 350-356
LID - 10.1159/000505659 [doi]
AB  - INTRODUCTION: Systemic sclerosis (SSc) is a chronic autoimmune disease 
      characterized by microvascular damage and fibrosis of the skin and internal 
      organs. The major complications are lung fibrosis, pulmonary artery hypertension, 
      scleroderma renal crisis, and cardiac involvement. OBJECTIVE: The aim of this 
      study was to assess renal and cardiac involvement in asymptomatic SSc patients 
      using renal Doppler ultrasound (RDU) and cardiac magnetic resonance (CMR). 
      MATERIALS AND METHODS: We enrolled 26 consecutive SSc patients (21 female) 
      according to 2013 ACR/EULAR criteria. Biochemical analysis, clinical evaluation, 
      RDU with intrarenal hemodynamic parameters (renal resistive index [RRI], 
      pulsatility index [PI], systolic/diastolic [S/D] ratio), and CMR with late 
      gadolinium enhancement (LGE) were investigated at the time of enrollment. 
      RESULTS: The median PI value was significantly (p = 0.007) higher in SSc patients 
      with LGE than in SSc patients without LGE (1.37 [1.28-1.58] vs. 1.12 
      [1.06-1.26]). The median RRI value was significantly (p = 0.002) higher in SSc 
      patients with LGE than in SSc patients without LGE (0.68 [0.65-0.73] vs. 0.64 
      [0.63-0.65]). The median S/D ratio was significantly (p = 0.02) higher in SSc 
      patients with LGE than in SSc patients without LGE (3.12 [2.83-3.76] vs. 2.78 
      [2.64-2.84]). CONCLUSIONS: Our study, although performed on a small SSc 
      population, showed RRI and LGE as markers of vascular and fibrotic damage. Early 
      detection of cardiorenal involvement in SSc patients without symptoms is 
      important to avoid further complications.
CI  - (c) 2020 The Author(s) Published by S. Karger AG, Basel.
FAU - Cianci, Rosario
AU  - Cianci R
AD  - Department of Translational and Precision Medicine, Sapienza University of Rome, 
      Rome, Italy.
FAU - Gigante, Antonietta
AU  - Gigante A
AD  - Department of Translational and Precision Medicine, Sapienza University of Rome, 
      Rome, Italy, antonietta.gigante@uniroma1.it.
FAU - Gasperini, Maria Ludovica
AU  - Gasperini ML
AD  - Department of Translational and Precision Medicine, Sapienza University of Rome, 
      Rome, Italy.
FAU - Barbano, Biagio
AU  - Barbano B
AD  - Department of Translational and Precision Medicine, Sapienza University of Rome, 
      Rome, Italy.
FAU - Galea, Nicola
AU  - Galea N
AD  - Department of Radiological, Oncological and Pathological Sciences, Sapienza 
      University of Rome, Rome, Italy.
FAU - Rosato, Edoardo
AU  - Rosato E
AD  - Department of Translational and Precision Medicine, Sapienza University of Rome, 
      Rome, Italy.
LA  - eng
PT  - News
DEP - 20200226
PL  - Switzerland
TA  - Kidney Blood Press Res
JT  - Kidney & blood pressure research
JID - 9610505
RN  - 0 (Contrast Media)
RN  - AU0V1LM3JT (Gadolinium)
SB  - IM
MH  - Adult
MH  - Contrast Media/*adverse effects
MH  - Female
MH  - Gadolinium/*adverse effects/pharmacology/physiology
MH  - Humans
MH  - Kidney/*chemistry/pathology
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Scleroderma, Systemic/*diagnostic imaging
OTO - NOTNLM
OT  - Cardiac magnetic resonance
OT  - Late gadolinium enhancement
OT  - Renal Doppler ultrasound
OT  - Renal resistive index
OT  - Systemic sclerosis
EDAT- 2020/02/27 06:00
MHDA- 2020/11/05 06:00
CRDT- 2020/02/27 06:00
PHST- 2019/10/09 00:00 [received]
PHST- 2019/12/28 00:00 [accepted]
PHST- 2020/02/27 06:00 [pubmed]
PHST- 2020/11/05 06:00 [medline]
PHST- 2020/02/27 06:00 [entrez]
AID - 000505659 [pii]
AID - 10.1159/000505659 [doi]
PST - ppublish
SO  - Kidney Blood Press Res. 2020;45(2):350-356. doi: 10.1159/000505659. Epub 2020 Feb 
      26.