PMID- 32102311
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 2304-8158 (Print)
IS  - 2304-8158 (Electronic)
IS  - 2304-8158 (Linking)
VI  - 9
IP  - 2
DP  - 2020 Feb 24
TI  - Antioxidant, Biochemical, and In-Life Effects of Punica granatum L. Natural Juice 
      vs. Clarified Juice by Polyvinylidene Fluoride Membrane.
LID - 10.3390/foods9020242 [doi]
LID - 242
AB  - A clarification method was proposed to ameliorate the technological quality of 
      fruit juices by preserving bioactive compounds. This study evaluated the in vitro 
      antioxidant and hypoglycemic activities and the in vivo effects of Punica 
      granatum L. natural (NJ) and clarified (CJ) juice by polyvinylidene fluoride 
      (PVDF) hollow fiber membrane. CJ was more active as an antioxidant and as a 
      alpha-glucosidase inhibitor than NJ. Mice were orally gavaged with water (Control), 
      NJ, and CJ for 28 days. NJ group showed significant decrease of alanine 
      aminotransferase, aspartate amino transferase, and creatine-phosphokinase. CJ 
      administration was associated with urea, creatine-phosphokinase, and 
      triglycerides values significantly lower with respect to the control. Oxidative 
      status was ameliorated with CJ administration, showing a reactive oxygen 
      metabolites (d-ROMs) reduction of 32% and a biological antioxidant potential 
      (BAP) boosting of 23% compared to the control, whereas NJ did not show a similar 
      effect. Results confirmed the beneficial properties of pomegranate juice, showing 
      that membrane clarification may enhance such effects in terms of antioxidant 
      activity.
FAU - Morittu, Valeria Maria
AU  - Morittu VM
AUID- ORCID: 0000-0001-6790-5734
AD  - C.I.S.-Interdepartmental Services Centre of Veterinary for Human and Animal 
      Health, Magna Graecia University of Catanzaro, Viale Europa, Loc. Germaneto, 
      88100 Catanzaro, Italy.
FAU - Mastellone, Vincenzo
AU  - Mastellone V
AD  - Department of Veterinary Medicine and Animal Production, University of Napoli 
      Federico II, 80100 Napoli, Italy.
FAU - Tundis, Rosa
AU  - Tundis R
AD  - Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 
      Via P. Bucci, Ed. Polifunzionale, 87030 Rende, Italy.
FAU - Loizzo, Monica Rosa
AU  - Loizzo MR
AUID- ORCID: 0000-0002-6050-9357
AD  - Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 
      Via P. Bucci, Ed. Polifunzionale, 87030 Rende, Italy.
FAU - Tudisco, Raffaella
AU  - Tudisco R
AUID- ORCID: 0000-0003-1378-0328
AD  - Department of Veterinary Medicine and Animal Production, University of Napoli 
      Federico II, 80100 Napoli, Italy.
FAU - Figoli, Alberto
AU  - Figoli A
AUID- ORCID: 0000-0002-3347-0506
AD  - Institute on Membrane Technology, Italian National Research Council (ITM-CNR), 
      Via P. Bucci, 87036 Rende, Italy.
FAU - Cassano, Alfredo
AU  - Cassano A
AUID- ORCID: 0000-0001-5919-2885
AD  - Institute on Membrane Technology, Italian National Research Council (ITM-CNR), 
      Via P. Bucci, 87036 Rende, Italy.
FAU - Musco, Nadia
AU  - Musco N
AUID- ORCID: 0000-0001-9490-9933
AD  - Department of Veterinary Medicine and Animal Production, University of Napoli 
      Federico II, 80100 Napoli, Italy.
FAU - Britti, Domenico
AU  - Britti D
AUID- ORCID: 0000-0001-7355-8791
AD  - C.I.S.-Interdepartmental Services Centre of Veterinary for Human and Animal 
      Health, Magna Graecia University of Catanzaro, Viale Europa, Loc. Germaneto, 
      88100 Catanzaro, Italy.
FAU - Infascelli, Federico
AU  - Infascelli F
AD  - Department of Veterinary Medicine and Animal Production, University of Napoli 
      Federico II, 80100 Napoli, Italy.
FAU - Lombardi, Pietro
AU  - Lombardi P
AD  - Department of Veterinary Medicine and Animal Production, University of Napoli 
      Federico II, 80100 Napoli, Italy.
LA  - eng
PT  - Journal Article
DEP - 20200224
PL  - Switzerland
TA  - Foods
JT  - Foods (Basel, Switzerland)
JID - 101670569
PMC - PMC7074394
OTO - NOTNLM
OT  - antioxidants
OT  - clarified juice
OT  - functional drink
OT  - hypoglycemic
OT  - pomegranate
COIS- The authors declare no conflict of interest.
EDAT- 2020/02/28 06:00
MHDA- 2020/02/28 06:01
PMCR- 2020/02/24
CRDT- 2020/02/28 06:00
PHST- 2020/01/27 00:00 [received]
PHST- 2020/02/16 00:00 [revised]
PHST- 2020/02/21 00:00 [accepted]
PHST- 2020/02/28 06:00 [entrez]
PHST- 2020/02/28 06:00 [pubmed]
PHST- 2020/02/28 06:01 [medline]
PHST- 2020/02/24 00:00 [pmc-release]
AID - foods9020242 [pii]
AID - foods-09-00242 [pii]
AID - 10.3390/foods9020242 [doi]
PST - epublish
SO  - Foods. 2020 Feb 24;9(2):242. doi: 10.3390/foods9020242.