PMID- 32103267
OWN - NLM
STAT- MEDLINE
DCOM- 20210201
LR  - 20210201
IS  - 1758-0463 (Electronic)
IS  - 1758-0463 (Linking)
VI  - 2020
DP  - 2020 Jan 1
TI  - Predicted Drosophila Interactome Resource and web tool for functional 
      interpretation of differentially expressed genes.
LID - 10.1093/database/baaa005 [doi]
LID - baaa005
AB  - Drosophila melanogaster is a well-established model organism that is widely used 
      in genetic studies. This species enjoys the availability of a wide range of 
      research tools, well-annotated reference databases and highly similar gene 
      circuitry to other insects. To facilitate molecular mechanism studies in 
      Drosophila, we present the Predicted Drosophila Interactome Resource (PDIR), a 
      database of high-quality predicted functional gene interactions. These 
      interactions were inferred from evidence in 10 public databases providing 
      information for functional gene interactions from diverse perspectives. The 
      current version of PDIR includes 102 835 putative functional associations with 
      balanced sensitivity and specificity, which are expected to cover 22.56% of all 
      Drosophila protein interactions. This set of functional interactions is a good 
      reference for hypothesis formulation in molecular mechanism studies. At the same 
      time, these interactions also serve as a high-quality reference interactome for 
      gene set linkage analysis (GSLA), which is a web tool for the interpretation of 
      the potential functional impacts of a set of changed genes observed in 
      transcriptomics analyses. In a case study, we show that the PDIR/GSLA system was 
      able to produce a more comprehensive and concise interpretation of the collective 
      functional impact of multiple simultaneously changed genes compared with the 
      widely used gene set annotation tools, including PANTHER and David. PDIR and its 
      associated GSLA service can be accessed at http://drosophila.biomedtzc.cn.
CI  - (c) The Author(s) 2020. Published by Oxford University Press.
FAU - Ding, Xiao-Bao
AU  - Ding XB
AD  - Institute of Big Data and Artificial Intelligence in Medicine, School of 
      Electronics and Information Engineering, Taizhou University, 1139 Shifu Avenue, 
      Taizhou 318000, China.
FAU - Jin, Jie
AU  - Jin J
AD  - Institute of Big Data and Artificial Intelligence in Medicine, School of 
      Electronics and Information Engineering, Taizhou University, 1139 Shifu Avenue, 
      Taizhou 318000, China.
FAU - Tao, Yu-Tian
AU  - Tao YT
AD  - Institute of Big Data and Artificial Intelligence in Medicine, School of 
      Electronics and Information Engineering, Taizhou University, 1139 Shifu Avenue, 
      Taizhou 318000, China.
FAU - Guo, Wen-Ping
AU  - Guo WP
AD  - Institute of Big Data and Artificial Intelligence in Medicine, School of 
      Electronics and Information Engineering, Taizhou University, 1139 Shifu Avenue, 
      Taizhou 318000, China.
FAU - Ruan, Li
AU  - Ruan L
AD  - Institute of Big Data and Artificial Intelligence in Medicine, School of 
      Electronics and Information Engineering, Taizhou University, 1139 Shifu Avenue, 
      Taizhou 318000, China.
FAU - Yang, Qiao-Lei
AU  - Yang QL
AD  - Institute of Pharmaceutical Biotechnology and the First Affiliated Hospital 
      Department of Radiation Oncology, Zhejiang University School of Medicine, 866 
      Yuhantang Rd, Hangzhou 310058, China.
FAU - Chen, Peng-Cheng
AU  - Chen PC
AD  - Institute of Pharmaceutical Biotechnology and the First Affiliated Hospital 
      Department of Radiation Oncology, Zhejiang University School of Medicine, 866 
      Yuhantang Rd, Hangzhou 310058, China.
FAU - Yao, Heng
AU  - Yao H
AD  - Institute of Pharmaceutical Biotechnology and the First Affiliated Hospital 
      Department of Radiation Oncology, Zhejiang University School of Medicine, 866 
      Yuhantang Rd, Hangzhou 310058, China.
FAU - Zhang, Hai-Bo
AU  - Zhang HB
AD  - Institute of Big Data and Artificial Intelligence in Medicine, School of 
      Electronics and Information Engineering, Taizhou University, 1139 Shifu Avenue, 
      Taizhou 318000, China.
FAU - Chen, Xin
AU  - Chen X
AD  - Institute of Big Data and Artificial Intelligence in Medicine, School of 
      Electronics and Information Engineering, Taizhou University, 1139 Shifu Avenue, 
      Taizhou 318000, China.
AD  - Institute of Pharmaceutical Biotechnology and the First Affiliated Hospital 
      Department of Radiation Oncology, Zhejiang University School of Medicine, 866 
      Yuhantang Rd, Hangzhou 310058, China.
AD  - Joint Institute for Genetics and Genome Medicine between Zhejiang University and 
      University of Toronto, Zhejiang University, 866 Yuhantang Rd, Hangzhou 310058, 
      China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Database (Oxford)
JT  - Database : the journal of biological databases and curation
JID - 101517697
RN  - 0 (Drosophila Proteins)
SB  - IM
MH  - Algorithms
MH  - Animals
MH  - *Databases, Genetic
MH  - Drosophila/classification/*genetics/metabolism
MH  - Drosophila Proteins/genetics/metabolism
MH  - Drosophila melanogaster/*genetics/metabolism
MH  - Gene Expression Profiling/*methods
MH  - Internet
MH  - Models, Genetic
MH  - Protein Interaction Mapping/*methods
MH  - Reproducibility of Results
MH  - User-Computer Interface
PMC - PMC7044104
EDAT- 2020/02/28 06:00
MHDA- 2021/02/02 06:00
PMCR- 2020/02/25
CRDT- 2020/02/28 06:00
PHST- 2019/10/21 00:00 [received]
PHST- 2019/12/03 00:00 [revised]
PHST- 2020/01/13 00:00 [accepted]
PHST- 2020/02/28 06:00 [entrez]
PHST- 2020/02/28 06:00 [pubmed]
PHST- 2021/02/02 06:00 [medline]
PHST- 2020/02/25 00:00 [pmc-release]
AID - 5756140 [pii]
AID - baaa005 [pii]
AID - 10.1093/database/baaa005 [doi]
PST - ppublish
SO  - Database (Oxford). 2020 Jan 1;2020:baaa005. doi: 10.1093/database/baaa005.