PMID- 32103321
OWN - NLM
STAT- MEDLINE
DCOM- 20201207
LR  - 20201214
IS  - 1615-2573 (Electronic)
IS  - 0910-8327 (Linking)
VI  - 35
IP  - 7
DP  - 2020 Jul
TI  - Prognostic implication of global myocardial blood flow in patients with 
      ST-segment elevation myocardial infarction.
PG  - 936-945
LID - 10.1007/s00380-020-01570-8 [doi]
AB  - The prognostic implications of cardiovascular magnetic resonance imaging 
      (CMR)-derived hyperemic myocardial blood flow (MBF) in patients with ST-elevation 
      myocardial infarction (STEMI) are unknown. This study sought to investigate the 
      incremental prognostic value of hyperemic MBF over conventional CMR markers to 
      identify patients with high risk of future incidence of patient-oriented 
      composite outcomes (POCO) and major adverse cardiac events (MACE) after STEMI. A 
      total of 237 patients who presented with STEMI were prospectively enrolled. The 
      CMR protocol included left-ventricular ejection fraction (LVEF), late gadolinium 
      enhancement (LGE) and microvascular obstruction (MVO) measurement, and volumetric 
      MBF assessment. During a median follow-up of 2.6 years, 47 patients experienced 
      POCO (primary outcome) and 21 patients had MACE. In a multivariable model, 
      multivessel disease, LGE, MVO, and hyperemic MBF were independently associated 
      with POCO. Addition of hyperemic MBF to the model consisting of GRACE score, 
      multivessel disease, LVEF, LGE, and MVO significantly improved the predictive 
      efficacy (integrated discrimination improvement 0.020, p = 0.021). Patients with 
      low hyperemic MBF had significantly higher incidence of MACE compared to those 
      with high hyperemic MBF in propensity score matching analysis (p = 0.018). In 
      conclusion, CMR-derived hyperemic MBF could provide independent and incremental 
      prognostic value over LVEF, LGE, and MVO in patients with STEMI.
FAU - Hamaya, Rikuta
AU  - Hamaya R
AD  - Department of Cardiology, Tsuchiura Kyodo General Hospital, 4-4-1 Otsuno, 
      Tsuchiura, Ibaraki, 300-0028, Japan.
AD  - Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, 
      USA.
FAU - Kanaji, Yoshihisa
AU  - Kanaji Y
AD  - Department of Cardiology, Tsuchiura Kyodo General Hospital, 4-4-1 Otsuno, 
      Tsuchiura, Ibaraki, 300-0028, Japan.
FAU - Hada, Masahiro
AU  - Hada M
AD  - Department of Cardiology, Tsuchiura Kyodo General Hospital, 4-4-1 Otsuno, 
      Tsuchiura, Ibaraki, 300-0028, Japan.
FAU - Kanno, Yoshinori
AU  - Kanno Y
AD  - Department of Cardiology, Tsuchiura Kyodo General Hospital, 4-4-1 Otsuno, 
      Tsuchiura, Ibaraki, 300-0028, Japan.
FAU - Usui, Eisuke
AU  - Usui E
AD  - Department of Cardiology, Tsuchiura Kyodo General Hospital, 4-4-1 Otsuno, 
      Tsuchiura, Ibaraki, 300-0028, Japan.
FAU - Hoshino, Masahiro
AU  - Hoshino M
AD  - Department of Cardiology, Tsuchiura Kyodo General Hospital, 4-4-1 Otsuno, 
      Tsuchiura, Ibaraki, 300-0028, Japan.
FAU - Yamaguchi, Masao
AU  - Yamaguchi M
AD  - Department of Cardiology, Tsuchiura Kyodo General Hospital, 4-4-1 Otsuno, 
      Tsuchiura, Ibaraki, 300-0028, Japan.
FAU - Sumino, Yohei
AU  - Sumino Y
AD  - Department of Cardiology, Tsuchiura Kyodo General Hospital, 4-4-1 Otsuno, 
      Tsuchiura, Ibaraki, 300-0028, Japan.
FAU - Horie, Tomoki
AU  - Horie T
AD  - Department of Cardiology, Tsuchiura Kyodo General Hospital, 4-4-1 Otsuno, 
      Tsuchiura, Ibaraki, 300-0028, Japan.
FAU - Hirano, Hidenori
AU  - Hirano H
AD  - Department of Cardiology, Tsuchiura Kyodo General Hospital, 4-4-1 Otsuno, 
      Tsuchiura, Ibaraki, 300-0028, Japan.
FAU - Sugiyama, Tomoyo
AU  - Sugiyama T
AD  - Department of Cardiology, Tsuchiura Kyodo General Hospital, 4-4-1 Otsuno, 
      Tsuchiura, Ibaraki, 300-0028, Japan.
FAU - Kakuta, Tsunekazu
AU  - Kakuta T
AD  - Department of Cardiology, Tsuchiura Kyodo General Hospital, 4-4-1 Otsuno, 
      Tsuchiura, Ibaraki, 300-0028, Japan. kaz@joy.email.ne.jp.
LA  - eng
PT  - Journal Article
DEP - 20200226
PL  - Japan
TA  - Heart Vessels
JT  - Heart and vessels
JID - 8511258
SB  - IM
MH  - Aged
MH  - *Coronary Circulation
MH  - Coronary Sinus/*diagnostic imaging/physiopathology
MH  - Female
MH  - Heart Disease Risk Factors
MH  - Humans
MH  - Hyperemia/diagnostic imaging/physiopathology
MH  - *Magnetic Resonance Imaging, Cine
MH  - Male
MH  - Middle Aged
MH  - *Myocardial Perfusion Imaging
MH  - Percutaneous Coronary Intervention
MH  - Predictive Value of Tests
MH  - Reproducibility of Results
MH  - Retrospective Studies
MH  - Risk Assessment
MH  - ST Elevation Myocardial Infarction/*diagnostic imaging/physiopathology/therapy
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Cardiovascular magnetic resonance imaging
OT  - Coronary flow reserve
OT  - Myocardial blood flow
OT  - ST-segment elevation myocardial infarction
EDAT- 2020/02/28 06:00
MHDA- 2020/12/15 06:00
CRDT- 2020/02/28 06:00
PHST- 2019/10/15 00:00 [received]
PHST- 2020/02/14 00:00 [accepted]
PHST- 2020/02/28 06:00 [pubmed]
PHST- 2020/12/15 06:00 [medline]
PHST- 2020/02/28 06:00 [entrez]
AID - 10.1007/s00380-020-01570-8 [pii]
AID - 10.1007/s00380-020-01570-8 [doi]
PST - ppublish
SO  - Heart Vessels. 2020 Jul;35(7):936-945. doi: 10.1007/s00380-020-01570-8. Epub 2020 
      Feb 26.