PMID- 32103588
OWN - NLM
STAT- MEDLINE
DCOM- 20210927
LR  - 20210927
IS  - 1613-4133 (Electronic)
IS  - 1613-4125 (Linking)
VI  - 65
IP  - 1
DP  - 2021 Jan
TI  - Regulation of Adipocyte and Macrophage Functions by mTORC1 and 2 in Metabolic 
      Diseases.
PG  - e1900768
LID - 10.1002/mnfr.201900768 [doi]
AB  - SCOPE: Evidence gathered in the last decades suggests that lipotoxicity and 
      inflammation are the main factors connecting adipose tissue dysfunction to the 
      development of metabolic diseases such as insulin resistance, nonalcoholic fatty 
      liver disease (NAFLD), cardiovascular disease, and certain types of cancer, among 
      others. The mechanistic target of rapamycin (mTOR) is a serine threonine kinase 
      that functions as the catalytic entity of two multiprotein complexes, mTOR 
      complex 1 (mTORC1) and mTOR complex 2 (mTORC2). These complexes are important 
      components of signaling pathways activated by nutrients, growth factors, and 
      inflammatory mediators and are therefore directly involved in the regulation of 
      adipocyte and macrophage metabolism and function. METHODS AND RESULTS: In this 
      article, studies that evaluate the involvement of mTORC1 and 2 in the regulation 
      of macrophage and adipocyte function and their implication in the development of 
      metabolic-disease-associated adipose tissue dysfunction are reviewed. CONCLUSION: 
      In adipocytes, optimal levels of mTORC1 activity are required for its 
      pro-lipogenic actions, while in macrophages, mTORC1 regulates features of both M1 
      and M2 polarization. mTORC2, on the other hand, promotes glucose uptake and de 
      novo lipogenesis in adipocytes and counteracts macrophage inflammatory response.
CI  - (c) 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
FAU - Festuccia, William T
AU  - Festuccia WT
AUID- ORCID: 0000-0003-4769-0806
AD  - Department of Physiology and Biophysics, Institute of Biomedical Sciences, 
      University of Sao Paulo, Sao Paulo, 05508000, Brazil.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20200308
PL  - Germany
TA  - Mol Nutr Food Res
JT  - Molecular nutrition & food research
JID - 101231818
RN  - 0 (Inflammation Mediators)
RN  - EC 2.7.11.1 (Mechanistic Target of Rapamycin Complex 1)
RN  - EC 2.7.11.1 (Mechanistic Target of Rapamycin Complex 2)
SB  - IM
MH  - Adipocytes/*metabolism
MH  - Adipose Tissue, White/metabolism/*pathology
MH  - Animals
MH  - Humans
MH  - Inflammation Mediators/metabolism
MH  - Macrophages/*metabolism
MH  - Mechanistic Target of Rapamycin Complex 1/*metabolism
MH  - Mechanistic Target of Rapamycin Complex 2/*metabolism
MH  - Metabolic Diseases/metabolism
MH  - Obesity/metabolism/pathology
OTO - NOTNLM
OT  - adipose tissue
OT  - inflammation
OT  - lipotoxicity
OT  - rapamycin
EDAT- 2020/02/28 06:00
MHDA- 2021/09/28 06:00
CRDT- 2020/02/28 06:00
PHST- 2019/10/28 00:00 [received]
PHST- 2020/02/06 00:00 [revised]
PHST- 2020/02/28 06:00 [pubmed]
PHST- 2021/09/28 06:00 [medline]
PHST- 2020/02/28 06:00 [entrez]
AID - 10.1002/mnfr.201900768 [doi]
PST - ppublish
SO  - Mol Nutr Food Res. 2021 Jan;65(1):e1900768. doi: 10.1002/mnfr.201900768. Epub 
      2020 Mar 8.