PMID- 32104034
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231113
IS  - 1178-7007 (Print)
IS  - 1178-7007 (Electronic)
IS  - 1178-7007 (Linking)
VI  - 13
DP  - 2020
TI  - Correlation Between Diabetic Peripheral Neuropathy and Sarcopenia in Patients 
      with Type 2 Diabetes Mellitus and Diabetic Foot Disease: A Cross-Sectional Study.
PG  - 377-386
LID - 10.2147/DMSO.S237362 [doi]
AB  - PURPOSE: The present study was designed to determine the relationships between 
      sarcopenia and diabetic peripheral neuropathy (DPN) in patients with type 2 
      diabetes mellitus (T2DM) and diabetic foot disease (DFD) respectively. PATIENTS 
      AND METHODS: A total of 1104 patients with T2DM and 257 patients with DFD were 
      included in the study, which was designed as a cross-sectional study. Body 
      composition was assessed using dual-energy X-ray-absorptiometry (DXA). The 
      diagnosis of sarcopenia was based on the Baumgartner criteria. DPN was assessed 
      by Neuropathy symptom score (NSS) and Neuropathy disability score (NDS), and the 
      severity of neuropathy was divided into non-neuropathy symptom (NS), Mild NS, 
      Moderate NS and Severe NS according to NSS. Logistic regression analyses were 
      carried out to determine the relations of sarcopenia and DPN in patients with 
      T2DM and NSS in patients with DFD, respectively. RESULTS: The prevalence of DPN 
      was 80.0% in T2DM patients with sarcopenia and 70.3% in non-sarcopenia patients 
      (P=0.007). Logistic regression analyses showed DPN was one of the independent 
      risk factors for sarcopenia in T2DM patients (OR 1.564 [95% CI: 1.004, 2.435], 
      P=0.048). The prevalence of DPN had no statistical significance in DFD patients 
      with or without sarcopenia. However, the NSS of DFD patients with sarcopenia was 
      higher than that of non-sarcopenia patients. In the multivariate logistic 
      regression analysis, NSS was determined to be associated with sarcopenia in DFD 
      patients (OR 1.387[95% CI: 1.074, 1.789], P=0.012). The appendicular lean mass 
      (ALM) of DFD patients without NS was higher than patients with mild, moderate and 
      severe NS (20.71+/-2.73 vs 16.57+/-3.62 vs 17.99+/-3.54 vs 17.23+/-3.29 Kg, P=0.028). 
      CONCLUSION: DPN is an independent risk factor for sarcopenia in patients with 
      T2DM and NSS is also independently correlated with sarcopenia in patients with 
      DFD, with the latter being more obvious with the aggravation of neurological 
      symptoms in DFD patients.
CI  - (c) 2020 Yang et al.
FAU - Yang, Qin
AU  - Yang Q
AD  - Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing, People's Republic of China.
FAU - Zhang, Yingxiao
AU  - Zhang Y
AD  - Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing, People's Republic of China.
FAU - Zeng, Qinglian
AU  - Zeng Q
AD  - Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing, People's Republic of China.
FAU - Yang, Chan
AU  - Yang C
AD  - Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing, People's Republic of China.
FAU - Shi, Jiale
AU  - Shi J
AD  - Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing, People's Republic of China.
FAU - Zhang, Chunlin
AU  - Zhang C
AD  - Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing, People's Republic of China.
FAU - Ni, Xia
AU  - Ni X
AD  - Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing, People's Republic of China.
FAU - Du, Zhipeng
AU  - Du Z
AD  - Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing, People's Republic of China.
FAU - Tang, Ziwei
AU  - Tang Z
AD  - Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing, People's Republic of China.
FAU - Hu, Jinbo
AU  - Hu J
AUID- ORCID: 0000-0003-2925-0583
AD  - Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing, People's Republic of China.
FAU - Li, Xuemei
AU  - Li X
AD  - Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing, People's Republic of China.
FAU - Cai, Jiahui
AU  - Cai J
AD  - Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing, People's Republic of China.
FAU - Li, Qifu
AU  - Li Q
AD  - Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing, People's Republic of China.
FAU - Cheng, Qingfeng
AU  - Cheng Q
AUID- ORCID: 0000-0001-8676-5597
AD  - Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing, People's Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20200213
PL  - New Zealand
TA  - Diabetes Metab Syndr Obes
JT  - Diabetes, metabolic syndrome and obesity : targets and therapy
JID - 101515585
PMC - PMC7025667
OTO - NOTNLM
OT  - correlation
OT  - diabetic foot disease
OT  - diabetic peripheral neuropathy
OT  - sarcopenia
OT  - type 2 diabetes mellitus
COIS- No potential con fl icts of interest relevant to this article were reported.
EDAT- 2020/02/28 06:00
MHDA- 2020/02/28 06:01
PMCR- 2020/02/13
CRDT- 2020/02/28 06:00
PHST- 2019/11/05 00:00 [received]
PHST- 2020/01/10 00:00 [accepted]
PHST- 2020/02/28 06:00 [entrez]
PHST- 2020/02/28 06:00 [pubmed]
PHST- 2020/02/28 06:01 [medline]
PHST- 2020/02/13 00:00 [pmc-release]
AID - 237362 [pii]
AID - 10.2147/DMSO.S237362 [doi]
PST - epublish
SO  - Diabetes Metab Syndr Obes. 2020 Feb 13;13:377-386. doi: 10.2147/DMSO.S237362. 
      eCollection 2020.