PMID- 32104376
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240328
IS  - 2221-285X (Electronic)
IS  - 1818-0876 (Print)
IS  - 1818-0876 (Linking)
VI  - 13
IP  - 1
DP  - 2018 Jan
TI  - Buccal administration of mucoadhesive blend films saturated with propranolol 
      loaded nanoparticles.
PG  - 34-43
LID - 10.1016/j.ajps.2017.07.006 [doi]
AB  - The aims of this study were to prepare and characterize hydroxypropyl 
      methylcellulose (HPMC)/polycarbophil (PC) mucoadhesive blend films saturated with 
      propranolol hydrochloride (PNL)-loaded nanoparticles to improve permeability of 
      drugs that undergo first-pass metabolism. An ionic cross-linking method and film 
      casting technique was used to prepare nanoparticles and mucoadhesive blend films, 
      respectively. Increasing concentrations of PNL (70, 80, 90 mg/film) in HPMC/PC 
      blend films containing PNL-loaded nanoparticles (PN-films) and HPMC/PC blend 
      films containing PNL (80 mg/film) without nanoparticles (PP-films) were prepared 
      to test swelling, mucoadhesiveness, release, permeation and physicochemical 
      properties. Scanning electron microscope (SEM) images showed a partially smooth 
      surface with a wrinkled occurrence and spherically shaped, well-dispersed 
      nanoparticles on the surface of PN-films containing PNL 80 mg/film (PN-films-80). 
      The size of the nanoparticles on the surface of PN-films-80 was around 100 nm, 
      which was similar to the nanoparticle size observed using light scattering 
      technique. The swelling index (SI) of all PN-films and PP-films increased greatly 
      in the first period time (10-20 min) and reached swelling equilibrium at 20 min 
      and 30 min, respectively. For the PN-films, the concentration of PNL influenced 
      the mucoadhesive properties and tended to be higher when the amount of PNL 
      increased. Immediate release of all blend film formulations was found in early 
      time points (10-30 min). After 120 min, the release of PN-films-70 was lower than 
      the other PN-films. Permeation studies using porcine buccal mucosa showed that 
      inclusion of nanoparticles in the films increased the permeability of PNL 
      compared to PP-films. Therefore, buccal administration of mucoadhesive blend 
      films containing PNL-loaded nanoparticles could be a promising approach for drugs 
      that undergo first-pass metabolism.
CI  - (c) 2018 Shenyang Pharmaceutical University. Production and hosting by Elsevier 
      B.V.
FAU - Kraisit, Pakorn
AU  - Kraisit P
AD  - Division of Pharmaceutical Sciences, Faculty of Pharmacy, Thammasat University, 
      Pathumthani 12120, Thailand.
AD  - Pharmaceutical Biopolymer Group (PBiG), Faculty of Pharmacy, Silpakorn 
      University, Nakhon Pathom 73000, Thailand.
FAU - Limmatvapirat, Sontaya
AU  - Limmatvapirat S
AD  - Department of Pharmaceutical Technology, Faculty of Pharmacy, Silpakorn 
      University, Nakhon Pathom 73000, Thailand.
AD  - Pharmaceutical Biopolymer Group (PBiG), Faculty of Pharmacy, Silpakorn 
      University, Nakhon Pathom 73000, Thailand.
FAU - Luangtana-Anan, Manee
AU  - Luangtana-Anan M
AD  - Department of Pharmaceutical Technology, Faculty of Pharmacy, Silpakorn 
      University, Nakhon Pathom 73000, Thailand.
AD  - Pharmaceutical Biopolymer Group (PBiG), Faculty of Pharmacy, Silpakorn 
      University, Nakhon Pathom 73000, Thailand.
FAU - Sriamornsak, Pornsak
AU  - Sriamornsak P
AD  - Department of Pharmaceutical Technology, Faculty of Pharmacy, Silpakorn 
      University, Nakhon Pathom 73000, Thailand.
AD  - Pharmaceutical Biopolymer Group (PBiG), Faculty of Pharmacy, Silpakorn 
      University, Nakhon Pathom 73000, Thailand.
LA  - eng
PT  - Journal Article
DEP - 20170724
PL  - Netherlands
TA  - Asian J Pharm Sci
JT  - Asian journal of pharmaceutical sciences
JID - 101535338
PMC - PMC7032168
OTO - NOTNLM
OT  - Buccal drug delivery
OT  - Hydroxypropyl methylcellulose (HPMC)
OT  - Mucoadhesive film
OT  - Nanoparticle
OT  - Polycarbophil
OT  - Propranolol HCl
EDAT- 2018/01/01 00:00
MHDA- 2018/01/01 00:01
PMCR- 2017/07/24
CRDT- 2020/02/28 06:00
PHST- 2017/05/24 00:00 [received]
PHST- 2017/07/04 00:00 [revised]
PHST- 2017/07/20 00:00 [accepted]
PHST- 2020/02/28 06:00 [entrez]
PHST- 2018/01/01 00:00 [pubmed]
PHST- 2018/01/01 00:01 [medline]
PHST- 2017/07/24 00:00 [pmc-release]
AID - S1818-0876(17)30405-1 [pii]
AID - 10.1016/j.ajps.2017.07.006 [doi]
PST - ppublish
SO  - Asian J Pharm Sci. 2018 Jan;13(1):34-43. doi: 10.1016/j.ajps.2017.07.006. Epub 
      2017 Jul 24.