PMID- 32104383
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240328
IS  - 2221-285X (Electronic)
IS  - 1818-0876 (Print)
IS  - 1818-0876 (Linking)
VI  - 13
IP  - 2
DP  - 2018 Mar
TI  - ROS-responsive drug delivery systems for biomedical applications.
PG  - 101-112
LID - 10.1016/j.ajps.2017.11.002 [doi]
AB  - In the field of biomedicine, stimuli-responsive drug delivery systems (DDSs) have 
      become increasingly popular due to their site-specific release ability in 
      response to a certain physiological stimulus, which may result in both enhanced 
      treatment outcome and reduced side effects. Reactive oxygen species (ROS) are the 
      unavoidable consequence of cell oxidative metabolism. ROS play a crucial part in 
      regulating biological and physiological processes, whereas excessive 
      intracellular ROS usually lead to the oxidation stress which has implications in 
      several typical diseases such as cancer, inflammation and atherosclerosis. 
      Therefore, ROS-responsive DDSs have elicited widespread popularity for their 
      promising applications in a series of biomedical research because the payload is 
      only released in targeted cells or tissues that overproduce ROS. According to the 
      design of ROS-responsive DDSs, the main release mechanisms of therapeutic agents 
      can be ascribed to ROS-induced carrier solubility change, ROS-induced carrier 
      cleavage or ROS-induced prodrug linker cleavage. This review summarized the 
      latest development and novel design of ROS-responsive DDSs and discussed their 
      design concepts and the applications in the biomedical field.
CI  - (c) 2018 Shenyang Pharmaceutical University. Production and hosting by Elsevier 
      B.V.
FAU - Tao, Wenhui
AU  - Tao W
AD  - Wuya College of Innovation, Shenyang Pharmaceutical University, No. 103 Wenhua 
      Road, Shenyang 110016, China.
FAU - He, Zhonggui
AU  - He Z
AD  - Wuya College of Innovation, Shenyang Pharmaceutical University, No. 103 Wenhua 
      Road, Shenyang 110016, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20171202
PL  - Netherlands
TA  - Asian J Pharm Sci
JT  - Asian journal of pharmaceutical sciences
JID - 101535338
PMC - PMC7032079
OTO - NOTNLM
OT  - Applications
OT  - Drug delivery system
OT  - ROS-induced cleavage
OT  - ROS-induced solubility change
OT  - Reactive oxygen species
OT  - Stimuli-responsive
EDAT- 2018/03/01 00:00
MHDA- 2018/03/01 00:01
PMCR- 2017/12/02
CRDT- 2020/02/28 06:00
PHST- 2017/10/24 00:00 [received]
PHST- 2017/11/28 00:00 [revised]
PHST- 2017/11/28 00:00 [accepted]
PHST- 2020/02/28 06:00 [entrez]
PHST- 2018/03/01 00:00 [pubmed]
PHST- 2018/03/01 00:01 [medline]
PHST- 2017/12/02 00:00 [pmc-release]
AID - S1818-0876(17)30812-7 [pii]
AID - 10.1016/j.ajps.2017.11.002 [doi]
PST - ppublish
SO  - Asian J Pharm Sci. 2018 Mar;13(2):101-112. doi: 10.1016/j.ajps.2017.11.002. Epub 
      2017 Dec 2.