PMID- 32104712
OWN - NLM
STAT- MEDLINE
DCOM- 20201208
LR  - 20221207
IS  - 2314-6753 (Electronic)
IS  - 2314-6745 (Print)
VI  - 2020
DP  - 2020
TI  - The Effect of Diacerein on Type 2 Diabetic Mellitus: A Systematic Review and 
      Meta-Analysis of Randomized Controlled Trials with Trial Sequential Analysis.
PG  - 2593792
LID - 10.1155/2020/2593792 [doi]
LID - 2593792
AB  - AIMS: To figure out the effect of diacerein supplementation on type 2 diabetes 
      mellitus (T2DM). METHODS: An electronic search was processed on Pubmed, Embase, 
      and Cochrane library for randomized controlled trials (RCTs) comparing the 
      efficacy of diacerein with placebo on T2DM. The primary outcome was fasting blood 
      glucose (FBG). Trial sequential analysis (TSA) was used to test the reliability 
      of this pooled outcome. Secondary outcomes were glycosylated hemoglobin A1c 
      (HbA1c), body mass index (BMI), lipid profiles, hematological indexes including 
      hematocrit and platelet count, and systematic inflammatory level expressed as a 
      C-reactive protein (CRP) level. Safety outcome was the rate of complications. The 
      difference in continuous data was measured by mean difference (MD) and 95% 
      confidence interval (CI), while the difference of dichotomous data was calculated 
      by relative risk (RR) and 95% CI. A two-tailed P < 0.05 was regarded as 
      statistically significant. RESULTS: Five RCTs with 278 participants were 
      included. Compared with control, diacerein provided significant improvement on 
      FBG (MD -0.52; 95% CI (-0.89~-0.14); P < 0.05 was regarded as statistically 
      significant. P < 0.05 was regarded as statistically significant. P < 0.05 was 
      regarded as statistically significant. P < 0.05 was regarded as statistically 
      significant. P < 0.05 was regarded as statistically significant. CONCLUSION: 
      Based on the current analysis, diacerein as an add-on treatment provided better 
      glycemic control for T2DM but this benefit requires more verification. Compared 
      with control, additional diacerein also lowered body weight and CRP level in 
      T2DM, but increased the rate of gastrointestinal syndromes.
CI  - Copyright (c) 2020 Shizhe Guo et al.
FAU - Guo, Shizhe
AU  - Guo S
AD  - Internal Medicine Base, Yangpu Hospital, Tongji University School of Medicine, 
      Shanghai 200090, China.
FAU - Guo, Xianshan
AU  - Guo X
AD  - Department of Endocrinology, Xinxiang Central Hospital, Xinxiang, Henan 453000, 
      China.
FAU - Zhang, Hongya
AU  - Zhang H
AD  - Central Laboratory, Yang Pu District Center of Disease Control and Prevention, 
      Shanghai 200090, China.
FAU - Zhang, Xuan'e
AU  - Zhang X
AUID- ORCID: 0000-0002-4245-6124
AD  - Department of Endocrinology, Yangpu Hospital, Tongji University School of 
      Medicine, Shanghai 200090, China.
FAU - Li, Zhen
AU  - Li Z
AUID- ORCID: 0000-0002-6147-7545
AD  - Department of General Surgery, Yangpu Hospital, Tongji University School of 
      Medicine, Shanghai 200090, China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
DEP - 20200210
PL  - England
TA  - J Diabetes Res
JT  - Journal of diabetes research
JID - 101605237
RN  - 0 (Anthraquinones)
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Hypoglycemic Agents)
RN  - 4HU6J11EL5 (diacerein)
SB  - IM
MH  - Anthraquinones/*therapeutic use
MH  - Blood Glucose
MH  - Diabetes Mellitus, Type 2/blood/*drug therapy
MH  - Glycated Hemoglobin
MH  - Humans
MH  - Hypoglycemic Agents/*therapeutic use
MH  - Randomized Controlled Trials as Topic
MH  - Reproducibility of Results
MH  - Treatment Outcome
PMC - PMC7035565
COIS- The authors declare that they have no conflicts of interest.
EDAT- 2020/02/28 06:00
MHDA- 2020/12/15 06:00
PMCR- 2020/02/10
CRDT- 2020/02/28 06:00
PHST- 2019/09/19 00:00 [received]
PHST- 2020/01/02 00:00 [accepted]
PHST- 2020/02/28 06:00 [entrez]
PHST- 2020/02/28 06:00 [pubmed]
PHST- 2020/12/15 06:00 [medline]
PHST- 2020/02/10 00:00 [pmc-release]
AID - 10.1155/2020/2593792 [doi]
PST - epublish
SO  - J Diabetes Res. 2020 Feb 10;2020:2593792. doi: 10.1155/2020/2593792. eCollection 
      2020.