PMID- 32104785
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220413
IS  - 2574-0954 (Electronic)
IS  - 2574-0954 (Linking)
VI  - 9
IP  - 1
DP  - 2020 Mar
TI  - Effects of aerobic and anaerobic exercise on glucose tolerance in patients with 
      coronary heart disease and type 2 diabetes mellitus.
PG  - 3-8
LID - 10.1097/XCE.0000000000000188 [doi]
AB  - In patients with coronary heart disease (CHD) and type 2 diabetes mellitus 
      (T2DM), physical activity is strongly advised as nonpharmacological therapy. In 
      general, a moderate aerobic exercise intensity is recommended. It was also 
      proposed, however, that greater intensities tend to yield even greater benefits 
      in HbA1c. Hence, the most appropriate exercise intensity seems not to be 
      established yet. We compared the effect of moderate (aerobic) and vigorous 
      (anaerobic) activity on postprandial plasma glucose. METHODS: In 10 consecutive 
      patients (63 +/- 12 years, BMI 28.3 +/- 2.6 kg/m(2), fasting plasma glucose 
      6.1 +/- 1.2 mmol/l), 2-hour plasma glucose was >/=11.1 mmol/l in the oral glucose 
      tolerance test at rest (OGTT-0). Cardiopulmonary exercise test (CPX) was 
      performed until a respiratory exchange ratio (RER) >/=1.20, beeing anaerobic 
      (CPX-1), followed by OGTT-1. A steady-state CPX of 30-minute duration was 
      performed targeting an RER between 0.90 and 0.95, being aerobic (CPX-2), followed 
      by OGTT-2. RESULTS: In CPX-1, maximum exercise intensity (maxIntensity) averaged 
      at 99 +/- 30 Watt and peak oxygen consumption (VO(2peak)) reached 
      15.9 +/- 2.8 ml/min/kg. In CPX-2, aerobic intensity averaged at 29 +/- 9 Watt, 
      representing 31% of maxIntensity and 61% of VO(2peak). After aerobic exercise, 
      2-hour plasma glucose was significantly reduced to an average of 9.4 +/- 2.3 mmol/l 
      (P < 0.05). Anaerobic exercise did not reduce 2-hour plasma glucose as compared 
      to OGTT-0 (12.6 +/- 2.2 vs 12.6 +/- 3.9 mmol/l). CONCLUSION: Aerobic exercise 
      intensity was very low in our patients with CHD and T2DM. Postprandial plasma 
      glucose was reduced only by aerobic exercise. Larger studies on the optimal 
      exercise intensity are needed in this patient cohort.
CI  - Copyright (c) 2019 Wolters Kluwer Health, Inc. All rights reserved.
FAU - Schwaab, Bernhard
AU  - Schwaab B
AD  - Curschmann Klinik, Rehabilitation Clinic for Cardiology, Angiology and Diabetes, 
      Timmendorfer Strand.
FAU - Kafsack, Friderike
AU  - Kafsack F
AD  - Curschmann Klinik, Rehabilitation Clinic for Cardiology, Angiology and Diabetes, 
      Timmendorfer Strand.
FAU - Markmann, Edith
AU  - Markmann E
AD  - Curschmann Klinik, Rehabilitation Clinic for Cardiology, Angiology and Diabetes, 
      Timmendorfer Strand.
FAU - Schutt, Morten
AU  - Schutt M
AD  - Diabetologische Schwerpunktpraxis, Lubeck, Germany.
LA  - eng
PT  - Journal Article
DEP - 20200221
PL  - United States
TA  - Cardiovasc Endocrinol Metab
JT  - Cardiovascular endocrinology & metabolism
JID - 101730894
PMC - PMC7041874
OTO - NOTNLM
OT  - aerobic exercise
OT  - anaerobic exercise
OT  - coronary heart disease
OT  - exercise intensity
OT  - glucose tolerance
OT  - type 2 diabetes mellitus
COIS- There are no conflicts of interest.
EDAT- 2020/02/28 06:00
MHDA- 2020/02/28 06:01
PMCR- 2020/02/21
CRDT- 2020/02/28 06:00
PHST- 2019/08/24 00:00 [received]
PHST- 2019/10/22 00:00 [accepted]
PHST- 2020/02/28 06:00 [entrez]
PHST- 2020/02/28 06:00 [pubmed]
PHST- 2020/02/28 06:01 [medline]
PHST- 2020/02/21 00:00 [pmc-release]
AID - 10.1097/XCE.0000000000000188 [doi]
PST - epublish
SO  - Cardiovasc Endocrinol Metab. 2020 Feb 21;9(1):3-8. doi: 
      10.1097/XCE.0000000000000188. eCollection 2020 Mar.