PMID- 32106753 OWN - NLM STAT- MEDLINE DCOM- 20211103 LR - 20211103 IS - 1557-9042 (Electronic) IS - 0897-7151 (Print) IS - 0897-7151 (Linking) VI - 37 IP - 14 DP - 2020 Jul 15 TI - Monitoring Outcome after Hospital-Presenting Milder Spectrum Pediatric Traumatic Brain Injury Using the Glasgow Outcome Scale-Extended, Pediatric Revision. PG - 1627-1636 LID - 10.1089/neu.2019.6893 [doi] AB - The Glasgow Outcome Scale, Pediatric Revision (GOSE-P) is an assessment of "global outcome" designed as a developmentally appropriate version of the Glasgow Outcome Scale-Extended for use in clinical trials of children with traumatic brain injury (TBI). Initial testing describes validity across a wide age and injury severity spectrum, yet the GOSE-P's utility for monitoring children with milder injuries is less clear. We examined the level of agreement between the GOSE-P and the Health and Behavior Inventory (HBI), a TBI-related symptom checklist used to assess children with mild TBI for clinical and research purposes. Participants included children and adolescents 3-16 years of age (n = 50) who presented to two level 1 trauma centers within 24 h of injury, with a GCS of 13-15, who underwent clinical neuroimaging. Outcome was assessed 2 weeks and 3 months following injury. We examined the severity of TBI-related symptoms across disability categories identified using the GOSE-P, and the level of agreement between the two measures in identifying deficits 2 weeks following injury and improvement from 2 weeks to 3 months. Using the GOSE-P, 62% had deficits at 2 weeks, and 42% improved from 2 weeks to 3 months. Agreement between the GOSE-P and HBI was fair 2 weeks after TBI (k = 0.24-0.33), and poor for identifying subsequent improvement (k = 0.10-0.16). Modest agreement between the GOSE-P and the HBI may reflect restricted participation from diverse causes, including TBI, other bodily injuries, and prescribed activity restrictions, and highlights the need for multi-dimensional outcome batteries. FAU - Evans, Emily AU - Evans E AD - Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts, USA. AD - MGH Institute of Health Professions, Boston, Massachusetts, USA. AD - The Center for Gerontology and Healthcare Research, Brown University, Providence, Rhode Island, USA. FAU - Cook, Nathan E AU - Cook NE AD - Department of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, Massachusetts, USA. AD - Spaulding Rehabilitation Hospital and Spaulding Research Institute, Boston, Massachusetts, USA. AD - MassGeneral Hospital for Children Sports Concussion Program, Boston, Massachusetts, USA. FAU - Iverson, Grant L AU - Iverson GL AD - Department of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, Massachusetts, USA. AD - Spaulding Rehabilitation Hospital and Spaulding Research Institute, Boston, Massachusetts, USA. AD - MassGeneral Hospital for Children Sports Concussion Program, Boston, Massachusetts, USA. AD - Home Base, A Red Sox Foundation and Massachusetts General Hospital Program, Charlestown, Massachusetts, USA. FAU - Townsend, Elise L AU - Townsend EL AD - Department of Physical Therapy, School of Health and Rehabilitation Sciences, MGH Institute of Health Professions, Charlestown, Massachusetts, USA. FAU - Duhaime, Ann-Christine AU - Duhaime AC AD - Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts, USA. CN - TRACK-TBI Investigators LA - eng GR - U01 NS086090/NS/NINDS NIH HHS/United States PT - Clinical Trial PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20200415 PL - United States TA - J Neurotrauma JT - Journal of neurotrauma JID - 8811626 SB - IM MH - Adolescent MH - Brain Concussion/*diagnostic imaging/*physiopathology/therapy MH - Child MH - Child, Preschool MH - Female MH - Follow-Up Studies MH - Glasgow Outcome Scale/*standards/*trends MH - Hospitalization/*trends MH - Humans MH - Longitudinal Studies MH - Male MH - Recovery of Function/*physiology MH - Treatment Outcome PMC - PMC7339019 OTO - NOTNLM OT - brain concussion OT - brain injuries, traumatic OT - head injuries, closed OT - outcome assessment (healthcare) OT - pediatrics COIS- Emily Evans received support from the Center on Health Services Training and Research (CoHSTAR). Grant Iverson has received research support from test publishing companies including Psychological Assessment Resources, Inc. and CNS Vital Signs in the past (not in the past 5 years). He acknowledges unrestricted philanthropic support from ImPACT Applications, Inc., the Mooney-Reed Charitable Foundation, the Heinz Family Foundation, and the Spaulding Research Institute. He receives royalties for one neuropsychological test (Wisconsin Card Sorting Test-64 Card Version). No other conflict of interests or competing financial interests exist. FIR - Adeoye, Opeolu IR - Adeoye O FIR - Badjatia, Neeraj IR - Badjatia N FIR - Boase, Kim IR - Boase K FIR - Bodien, Yelena IR - Bodien Y FIR - Bullock, M Ross IR - Bullock MR FIR - Chesnut, Randall IR - Chesnut R FIR - Corrigan, John D IR - Corrigan JD FIR - Crawford, Karen IR - Crawford K FIR - Diaz-Arrastia, Ramon IR - Diaz-Arrastia R FIR - Dikmen, Sureyya IR - Dikmen S FIR - Ellenbogen, Richard IR - Ellenbogen R FIR - Feeser, V Ramana IR - Feeser VR FIR - Ferguson, Adam R IR - Ferguson AR FIR - Foreman, Brandon IR - Foreman B FIR - Gardner, Raquel IR - Gardner R FIR - Gaudette, Etienne IR - Gaudette E FIR - Giacino, Joseph IR - Giacino J FIR - Goldman, Dana IR - Goldman D FIR - Gonzalez, Luis IR - Gonzalez L FIR - Gopinath, Shankar IR - Gopinath S FIR - Gullapalli, Rao IR - Gullapalli R FIR - Hemphill, J Claude IR - Hemphill JC FIR - Hotz, Gillian IR - Hotz G FIR - Jain, Sonia IR - Jain S FIR - Korley, Frederick K IR - Korley FK FIR - Kramer, Joel IR - Kramer J FIR - Kreitzer, Natalie IR - Kreitzer N FIR - Levin, Harvey IR - Levin H FIR - Lindsell, Chris IR - Lindsell C FIR - Machamer, Joan IR - Machamer J FIR - Madden, Christopher IR - Madden C FIR - Manley, Geoffrey T IR - Manley GT FIR - Martin, Alastair IR - Martin A FIR - McAllister, Thomas IR - McAllister T FIR - McCrea, Michael IR - McCrea M FIR - Merchant, Randall IR - Merchant R FIR - Mukherjee, Pratik IR - Mukherjee P FIR - Nelson, Lindsay IR - Nelson L FIR - Ngwenya, Laura B IR - Ngwenya LB FIR - Noel, Florence IR - Noel F FIR - Okonkwo, David IR - Okonkwo D FIR - Palacios, Eva IR - Palacios E FIR - Perl, Daniel IR - Perl D FIR - Puccio, Ava IR - Puccio A FIR - Rabinowitz, Miri IR - Rabinowitz M FIR - Robertson, Claudia IR - Robertson C FIR - Rosand, Jonathan IR - Rosand J FIR - Sander, Angelle IR - Sander A FIR - Satris, Gabriella IR - Satris G FIR - Schnyer, David IR - Schnyer D FIR - Seabury, Seth IR - Seabury S FIR - Taylor, Sabrina IR - Taylor S FIR - Temkin, Nancy IR - Temkin N FIR - Toga, Arthur IR - Toga A FIR - Valadka, Alex IR - Valadka A FIR - Vassar, Mary IR - Vassar M FIR - Vespa, Paul IR - Vespa P FIR - Wang, Kevin IR - Wang K FIR - Yue, John K IR - Yue JK FIR - Yuh, Esther IR - Yuh E FIR - Zafonte, Ross IR - Zafonte R EDAT- 2020/02/29 06:00 MHDA- 2021/11/04 06:00 PMCR- 2021/07/15 CRDT- 2020/02/29 06:00 PHST- 2020/02/29 06:00 [pubmed] PHST- 2021/11/04 06:00 [medline] PHST- 2020/02/29 06:00 [entrez] PHST- 2021/07/15 00:00 [pmc-release] AID - 10.1089/neu.2019.6893 [pii] AID - 10.1089/neu.2019.6893 [doi] PST - ppublish SO - J Neurotrauma. 2020 Jul 15;37(14):1627-1636. doi: 10.1089/neu.2019.6893. Epub 2020 Apr 15.