PMID- 32107122
OWN - NLM
STAT- MEDLINE
DCOM- 20210920
LR  - 20210920
IS  - 1873-460X (Electronic)
IS  - 1056-8727 (Linking)
VI  - 34
IP  - 5
DP  - 2020 May
TI  - Sex-influenced association of metabolic syndrome with lower extremity arterial 
      disease in type 2 diabetes.
PG  - 107537
LID - S1056-8727(19)30995-X [pii]
LID - 10.1016/j.jdiacomp.2020.107537 [doi]
AB  - AIM: The present study is undertaken to investigate the relationship between 
      metabolic syndrome (MS) and lower extremity arterial disease (LEAD) in type 2 
      diabetes mellitus (T2DM) patients. METHODS: A multi-center cross-sectional study 
      was conducted on 8374 T2DM patients (4521 males and 3853 females) from 30 
      hospitals across China from June 2016 to January 2017. The odds ratios (ORs) and 
      95% confidence intervals (CIs) were presented to show the association between MS 
      and LEAD. The univariate and multiple logistic analyses were performed to examine 
      the association between MS and the prevalence of LEAD. Furthermore, the 
      relationship was analyzed in different sex groups. Subgroup analysis was 
      performed based on the number and individual of MS components. RESULTS: Finally, 
      1809(21.60%) T2DM patients meet the diagnostic criteria of LEAD. Of the 3853 
      female subjects, 841(21.83%) patients were in the LEAD group and of the 4521 male 
      subjects, 968(21.41%) patients were in the LEAD group. When adjusting for 
      confounding variables, MS was significantly associated with the prevalence of 
      LEAD in all enrolled T2DM patients (OR = 1.22, 95%CI: 1.09-1.37, P = 0.001). 
      However, upon analyzing LEAD in different sex groups, the significant association 
      remained in females (OR = 1.33, 95%CI: 1.12-1.58, P < 0.001), but not in males 
      (OR = 1.11, 95%CI: 0.95-1.29, P = 0.202). CONCLUSIONS: Our results suggest that 
      MS is specifically associated with an increased risk of LEAD in female T2DM 
      patients. However, MS may not be a significant factor in the prevalence of LEAD 
      in male T2DM patients.
CI  - Copyright (c) 2020 Elsevier Inc. All rights reserved.
FAU - Chen, Qinfen
AU  - Chen Q
AD  - Medical Care (physical examination) Center, the First Affiliated Hospital of 
      Wenzhou Medical University, Wenzhou 325000, China.
FAU - Zhu, Hong
AU  - Zhu H
AD  - Department of Endocrinology, the First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou 325000, China.
FAU - Shen, Feixia
AU  - Shen F
AD  - Department of Endocrinology, the First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou 325000, China.
FAU - Zhang, Xiaomei
AU  - Zhang X
AD  - Department of Endocrinology, Peking University International Hospital, Beijing 
      102206, China.
FAU - Xu, Zhangrong
AU  - Xu Z
AD  - Diabetes Center, Department of Endocrinology, The 306th Hospital of PLA, Beijing, 
      China.
FAU - Ran, Xingwu
AU  - Ran X
AD  - Department of Endocrinology and Metabolism, West China Hospital, Sichuan 
      University, Chengdu 610041, China. Electronic address: ranxingwu@163.com.
FAU - Ji, Linong
AU  - Ji L
AD  - Department of Endocrinology, Peking University International Hospital, Beijing 
      102206, China; Department of Endocrinology and Metabolism, Peking University 
      People's Hospital, Beijing 100044, China. Electronic address: jiln@bjmu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20200118
PL  - United States
TA  - J Diabetes Complications
JT  - Journal of diabetes and its complications
JID - 9204583
SB  - IM
MH  - Aged
MH  - China/epidemiology
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*epidemiology
MH  - Diabetic Angiopathies/*epidemiology
MH  - Female
MH  - Humans
MH  - Lower Extremity/*blood supply
MH  - Male
MH  - Metabolic Syndrome/*epidemiology
MH  - Middle Aged
MH  - Peripheral Arterial Disease/*epidemiology
MH  - Prevalence
MH  - Sex Factors
OTO - NOTNLM
OT  - Lower extremity arterial disease
OT  - Metabolic syndrome
OT  - Type 2 diabetes mellitus
COIS- Declaration of competing interest No competing interests exist for the authors.
EDAT- 2020/02/29 06:00
MHDA- 2021/09/21 06:00
CRDT- 2020/02/29 06:00
PHST- 2019/09/02 00:00 [received]
PHST- 2019/12/28 00:00 [revised]
PHST- 2020/01/14 00:00 [accepted]
PHST- 2020/02/29 06:00 [pubmed]
PHST- 2021/09/21 06:00 [medline]
PHST- 2020/02/29 06:00 [entrez]
AID - S1056-8727(19)30995-X [pii]
AID - 10.1016/j.jdiacomp.2020.107537 [doi]
PST - ppublish
SO  - J Diabetes Complications. 2020 May;34(5):107537. doi: 
      10.1016/j.jdiacomp.2020.107537. Epub 2020 Jan 18.