PMID- 32107597
OWN - NLM
STAT- MEDLINE
DCOM- 20200501
LR  - 20240328
IS  - 1432-0703 (Electronic)
IS  - 0090-4341 (Print)
IS  - 0090-4341 (Linking)
VI  - 78
IP  - 4
DP  - 2020 May
TI  - Polychlorinated Biphenyls (PCBs) and Sex Hormone Concentrations in Ringed and 
      Grey Seals: A Possible Link to Endocrine Disruption?
PG  - 513-524
LID - 10.1007/s00244-020-00716-z [doi]
AB  - Polychlorinated biphenyls (PCBs) are recognised reproductive and immune system 
      toxicants in marine mammals mediated by endocrine-disrupting mechanisms. As with 
      other predators, seals are exposed to elevated bioaccumulated concentrations of 
      PCBs and other persistent organic pollutants (POPs). Cryopreserved plasma samples 
      from adult ringed (Phoca hispida; n = 39) and grey (Halichoerus grypus; n = 38) 
      seals, sampled between 1998 and 2002 from Baltic Sea, Svalbard, and Sable Island 
      (Canada) were used to investigate relationships between PCB exposure and sex 
      hormone concentrations (progesterone; P4, 17alpha-hydroxy progesterone; 17alpha-OH-P4, 
      testosterone; T4, 17beta-estradiol; E2, estrone; E3). Immunoassay methods were used 
      for quantification of analytes due to the limited sample volumes available. PCB 
      concentrations were found to be significantly higher in Baltic seals than other 
      sampling locations and were classed as "Exposed" seals while Svalbard and Sable 
      Is seal were classed "Reference" seals (sexes and species separate). Mean hormone 
      concentrations in Exposed seal were lower than Reference seals, and this was 
      statistically significantly for 17alpha-OH-P4 (both sexes and both species), E2 
      (ringed and grey seal females), and E3 (grey seal females). Regression analyses 
      (PCB v hormone concentrations) for each sex and species revealed significant 
      correlations for P4 (Sable Is. female grey seals and female ringed seals), 
      17alpha-OH-P4 (Sable Is. male grey seals and Svalbard male ringed seals), T4 
      (Svalbard male ringed seals), E2 (female ringed seals), and E3 (female ringed 
      seals and Baltic female grey seals). Although significant correlations are not 
      evidence of cause and effect, the potential impact of hormone changes on 
      endocrine homeostasis and reproductive health for seal populations warrants 
      further investigation given that PCB concentrations found here are in the same 
      range as those currently reported in seals from these populations.
FAU - Troisi, G M
AU  - Troisi GM
AUID- ORCID: 0000-0003-0889-9834
AD  - Department of Mechanical & Aerospace Engineering and Institute for Environment, 
      Health & Societies, College of Engineering, Design and Physical Sciences, Brunel 
      University London, Kingston Lane, Uxbridge, UB8 3PH, UK. 
      gera.troisi@brunel.ac.uk.
FAU - Barton, S J
AU  - Barton SJ
AD  - Department of Chemical and Pharmaceutical Sciences, Kingston University, Penrhyn 
      Road, Kingston-upon-Thames, Surrey, KT1 2EE, UK.
FAU - Liori, O
AU  - Liori O
AD  - Department of Chemical and Pharmaceutical Sciences, Kingston University, Penrhyn 
      Road, Kingston-upon-Thames, Surrey, KT1 2EE, UK.
FAU - Nyman, M
AU  - Nyman M
AD  - Finnish Game and Fisheries Research Institute, Metsahallitus, Kirjaamo, P.O. Box 
      94, Vantaainland, 01301, Finland.
LA  - eng
PT  - Journal Article
DEP - 20200227
PL  - United States
TA  - Arch Environ Contam Toxicol
JT  - Archives of environmental contamination and toxicology
JID - 0357245
RN  - 0 (Endocrine Disruptors)
RN  - 0 (Gonadal Steroid Hormones)
RN  - 0 (Water Pollutants, Chemical)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Animals
MH  - Canada
MH  - Endocrine Disruptors/analysis/*toxicity
MH  - Female
MH  - Gonadal Steroid Hormones/*blood
MH  - Male
MH  - Oceans and Seas
MH  - Polychlorinated Biphenyls/analysis/*toxicity
MH  - Seals, Earless/*blood
MH  - Seawater/chemistry
MH  - Svalbard
MH  - Water Pollutants, Chemical/analysis/*toxicity
PMC - PMC7136188
EDAT- 2020/02/29 06:00
MHDA- 2020/05/02 06:00
PMCR- 2020/02/27
CRDT- 2020/02/29 06:00
PHST- 2019/08/16 00:00 [received]
PHST- 2020/01/31 00:00 [accepted]
PHST- 2020/02/29 06:00 [pubmed]
PHST- 2020/05/02 06:00 [medline]
PHST- 2020/02/29 06:00 [entrez]
PHST- 2020/02/27 00:00 [pmc-release]
AID - 10.1007/s00244-020-00716-z [pii]
AID - 716 [pii]
AID - 10.1007/s00244-020-00716-z [doi]
PST - ppublish
SO  - Arch Environ Contam Toxicol. 2020 May;78(4):513-524. doi: 
      10.1007/s00244-020-00716-z. Epub 2020 Feb 27.