PMID- 32110380
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220413
IS  - 2045-7022 (Print)
IS  - 2045-7022 (Electronic)
IS  - 2045-7022 (Linking)
VI  - 10
DP  - 2020
TI  - Study of atopic multimorbidity in subjects with rhinitis using multiplex allergen 
      component analysis.
PG  - 6
LID - 10.1186/s13601-020-0311-6 [doi]
LID - 6
AB  - BACKGROUND: Rhinitis is a common problem within the population. Many subjects 
      with rhinitis also have atopic multimorbidity, such as asthma and eczema. The 
      purpose of this investigation was to compare subjects with only rhinitis to those 
      that have rhinitis, asthma and/or eczema in relation to immunoglobulin E (IgE) 
      sensitization, inflammatory markers, family history, lung function and body mass 
      index (BMI). METHODS: A total of 216 adult subjects with rhinitis from the 
      European Community Respiratory Health Survey II were investigated with multiplex 
      component allergen analysis (103 allergen components), total IgE, C-reactive 
      protein, eosinophilic cationic protein, fractional exhaled nitric oxide and 
      spirometry. Rhinitis, eczema, asthma and parental allergy were 
      questionnaire-assessed. RESULTS: Of the 216 participants with rhinitis, 89 also 
      had asthma and/or eczema. Participants with rhinitis that also had asthma or 
      eczema were more likely to be IgE-sensitized (3.44, odds ratio, OR: 95% CI 
      1.62-7.30, adjusted for sex, age, mother's allergy, total IgE and forced 
      expiratory volume (FEV(1))). The number of IgE-positive components was 
      independently associated with atopic multimorbidity (1.11, OR: 95% Cl 1.01-1.21) 
      adjusted for sex, age, mother's allergy, total IgE and FEV(1). When analysing 
      different types of sensitization, the strongest association with atopic 
      multimorbidity was found in participants that were IgE-sensitized both to 
      perennial and seasonal allergens (4.50, OR: 95% CI 1.61-12.5). Maternal allergy 
      (2.75, OR: 95% CI 1.15-4.46), high total IgE (2.38, OR: 95% CI 1.21-4.67) and 
      lower FEV(1) (0.73, OR: 95% CI 0.58-0.93) were also independently associated with 
      atopic multimorbidity, while no association was found with any of the other 
      inflammatory markers. CONCLUSION: IgE polysensitization, to perennial and 
      seasonal allergens, and levels of total IgE seem to be the main determinants of 
      atopic multimorbidity in subjects with rhinitis. This indicates that 
      disease-modifying treatment that targets IgE sensitization may be of value when 
      decreasing the risk of developing atopic multimorbidity.
CI  - (c) The Author(s) 2020.
FAU - Blondal, Viiu
AU  - Blondal V
AUID- ORCID: 0000-0002-9172-9555
AD  - 1Medical Sciences, Respiratory, Allergy and Sleep Research, Uppsala University, 
      Uppsala, Sweden. GRID: grid.8993.b. ISNI: 0000 0004 1936 9457
AD  - 4Department of Medical Sciences, Lung Allergy and Sleep Research, Uppsala 
      University Hospital, Uppsala University, 751 85 Uppsala, Sweden. GRID: 
      grid.8993.b. ISNI: 0000 0004 1936 9457
FAU - Sundbom, Fredrik
AU  - Sundbom F
AD  - 1Medical Sciences, Respiratory, Allergy and Sleep Research, Uppsala University, 
      Uppsala, Sweden. GRID: grid.8993.b. ISNI: 0000 0004 1936 9457
FAU - Borres, Magnus P
AU  - Borres MP
AD  - 2Women's and Children's Health, Uppsala University, Uppsala, Sweden. GRID: 
      grid.8993.b. ISNI: 0000 0004 1936 9457
AD  - Thermo Fischer Scientific, Uppsala, Sweden.
FAU - Hogman, Marieann
AU  - Hogman M
AD  - 1Medical Sciences, Respiratory, Allergy and Sleep Research, Uppsala University, 
      Uppsala, Sweden. GRID: grid.8993.b. ISNI: 0000 0004 1936 9457
FAU - Alving, Kjell
AU  - Alving K
AD  - 2Women's and Children's Health, Uppsala University, Uppsala, Sweden. GRID: 
      grid.8993.b. ISNI: 0000 0004 1936 9457
FAU - Malinovschi, Andrei
AU  - Malinovschi A
AD  - 1Medical Sciences, Respiratory, Allergy and Sleep Research, Uppsala University, 
      Uppsala, Sweden. GRID: grid.8993.b. ISNI: 0000 0004 1936 9457
FAU - Janson, Christer
AU  - Janson C
AD  - 1Medical Sciences, Respiratory, Allergy and Sleep Research, Uppsala University, 
      Uppsala, Sweden. GRID: grid.8993.b. ISNI: 0000 0004 1936 9457
LA  - eng
PT  - Journal Article
DEP - 20200221
PL  - England
TA  - Clin Transl Allergy
JT  - Clinical and translational allergy
JID - 101576043
PMC - PMC7033937
OTO - NOTNLM
OT  - Asthma
OT  - Atopic multimorbidity
OT  - Eczema
OT  - Multiplex component analysis
OT  - Rhinitis
COIS- Competing interestsMagnus P. Borres is affiliated with Thermofisher Scientific 
      (Sweden) that also provided financial support for this study. No other author has 
      reported any conflict of interest.
EDAT- 2020/02/29 06:00
MHDA- 2020/02/29 06:01
PMCR- 2020/02/21
CRDT- 2020/02/29 06:00
PHST- 2019/09/30 00:00 [received]
PHST- 2020/02/06 00:00 [accepted]
PHST- 2020/02/29 06:00 [entrez]
PHST- 2020/02/29 06:00 [pubmed]
PHST- 2020/02/29 06:01 [medline]
PHST- 2020/02/21 00:00 [pmc-release]
AID - 311 [pii]
AID - 10.1186/s13601-020-0311-6 [doi]
PST - epublish
SO  - Clin Transl Allergy. 2020 Feb 21;10:6. doi: 10.1186/s13601-020-0311-6. 
      eCollection 2020.