PMID- 32110958
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 2072-6694 (Print)
IS  - 2072-6694 (Electronic)
IS  - 2072-6694 (Linking)
VI  - 12
IP  - 3
DP  - 2020 Feb 26
TI  - Dose Reduction to the Swallowing Apparatus and the Salivary Glands by 
      De-Intensification of Postoperative Radiotherapy in Patients with Head and Neck 
      Cancer: First (Treatment Planning) Results of the Prospective Multicenter DIREKHT 
      Trial.
LID - 10.3390/cancers12030538 [doi]
LID - 538
AB  - AIM: Evaluating radiotherapy treatment plans of the prospective DIREKHT trial 
      (ClinicalTrials.gov, NCT02528955) investigating de-intensification of 
      radiotherapy in patients with head and neck cancer. PATIENTS AND METHODS: The 
      first 30 patients from the DIREKHT trial of the leading study centre were 
      included in this analysis. Standard treatment plans and study treatment plans 
      derived from the protocol were calculated for each patient. Sizes of planning 
      target volumes (PTVs) and mean doses to organs at risk were compared using the 
      Student's t-test with paired samples. RESULTS: Mean PTV3 including primary tumor 
      region and ipsilateral elective neck up to a dose of 50 Gy in the study treatment 
      plans was 662 mL (+/- 165 mL standard deviation (SD)) and therefore significantly 
      smaller than those of the standard treatment plans (1166 mL (+/- 266 mL SD). In 
      the medial and inferior constrictor muscles, cricopharyngeal muscle, glottic and 
      supraglottic laryngeal areas, arytenoid cartilages, contralateral major salivary 
      glands highly significant dose reductions (p < 0.0001) of more than 10 Gy were 
      achieved in study treatment plan compared to standard treatment plan. CONCLUSION: 
      De-intensification of radiotherapy led to smaller planning target volumes and 
      clinical relevant dose reductions in the swallowing apparatus and in the 
      contralateral salivary glands.
FAU - Haderlein, Marlen
AU  - Haderlein M
AD  - Department of Radiation Oncology, Universitatsklinikum Erlangen, 
      Friedrich-Alexander-Universitat Erlangen-Nurnberg (FAU), 91054 Erlangen, Germany.
FAU - Speer, Stefan
AU  - Speer S
AD  - Department of Radiation Oncology, Universitatsklinikum Erlangen, 
      Friedrich-Alexander-Universitat Erlangen-Nurnberg (FAU), 91054 Erlangen, Germany.
FAU - Ott, Oliver
AU  - Ott O
AD  - Department of Radiation Oncology, Universitatsklinikum Erlangen, 
      Friedrich-Alexander-Universitat Erlangen-Nurnberg (FAU), 91054 Erlangen, Germany.
FAU - Lettmaier, Sebastian
AU  - Lettmaier S
AD  - Department of Radiation Oncology, Universitatsklinikum Erlangen, 
      Friedrich-Alexander-Universitat Erlangen-Nurnberg (FAU), 91054 Erlangen, Germany.
FAU - Hecht, Markus
AU  - Hecht M
AD  - Department of Radiation Oncology, Universitatsklinikum Erlangen, 
      Friedrich-Alexander-Universitat Erlangen-Nurnberg (FAU), 91054 Erlangen, Germany.
FAU - Semrau, Sabine
AU  - Semrau S
AD  - Department of Radiation Oncology, Universitatsklinikum Erlangen, 
      Friedrich-Alexander-Universitat Erlangen-Nurnberg (FAU), 91054 Erlangen, Germany.
FAU - Frey, Benjamin
AU  - Frey B
AD  - Department of Radiation Oncology, Universitatsklinikum Erlangen, 
      Friedrich-Alexander-Universitat Erlangen-Nurnberg (FAU), 91054 Erlangen, Germany.
FAU - Scherl, Claudia
AU  - Scherl C
AD  - Department of Otorhinolaryngology, Universitatsklinikum Mannheim, Medical Faculty 
      Mannheim, University of Heidelberg, 68167 Mannheim, Germany.
AD  - Department of Otorhinolaryngology, Universitatsklinikum, 
      Friedrich-Alexander-Universitat Erlangen-Nurnberg (FAU), 91054 Erlangen, Germany.
FAU - Iro, Heinrich
AU  - Iro H
AD  - Department of Otorhinolaryngology, Universitatsklinikum, 
      Friedrich-Alexander-Universitat Erlangen-Nurnberg (FAU), 91054 Erlangen, Germany.
FAU - Kesting, Marco
AU  - Kesting M
AD  - Department of Oral and Maxillofacial Surgery, Universitatsklinikum, 
      Friedrich-Alexander-Universitat Erlangen-Nurnberg (FAU), 91054 Erlangen, Germany.
FAU - Fietkau, Rainer
AU  - Fietkau R
AD  - Department of Radiation Oncology, Universitatsklinikum Erlangen, 
      Friedrich-Alexander-Universitat Erlangen-Nurnberg (FAU), 91054 Erlangen, Germany.
LA  - eng
SI  - ClinicalTrials.gov/NCT02528955
PT  - Journal Article
DEP - 20200226
PL  - Switzerland
TA  - Cancers (Basel)
JT  - Cancers
JID - 101526829
PMC - PMC7139715
OTO - NOTNLM
OT  - de-intensification
OT  - head neck cancer
OT  - ipsilateral elective neck irradiation only
OT  - postoperative
OT  - radiotherapy
OT  - salivary glands
OT  - swallowing apparatus
COIS- On behalf of all authors the corresponding author states that there is no 
      conflict of interest.
EDAT- 2020/03/01 06:00
MHDA- 2020/03/01 06:01
PMCR- 2020/02/26
CRDT- 2020/03/01 06:00
PHST- 2020/01/15 00:00 [received]
PHST- 2020/02/07 00:00 [revised]
PHST- 2020/02/20 00:00 [accepted]
PHST- 2020/03/01 06:00 [entrez]
PHST- 2020/03/01 06:00 [pubmed]
PHST- 2020/03/01 06:01 [medline]
PHST- 2020/02/26 00:00 [pmc-release]
AID - cancers12030538 [pii]
AID - cancers-12-00538 [pii]
AID - 10.3390/cancers12030538 [doi]
PST - epublish
SO  - Cancers (Basel). 2020 Feb 26;12(3):538. doi: 10.3390/cancers12030538.