PMID- 32111063
OWN - NLM
STAT- MEDLINE
DCOM- 20201208
LR  - 20201214
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 21
IP  - 5
DP  - 2020 Feb 26
TI  - Guanosine-Based Nucleotides, the Sons of a Lesser God in the Purinergic Signal 
      Scenario of Excitable Tissues.
LID - 10.3390/ijms21051591 [doi]
LID - 1591
AB  - Purines are nitrogen compounds consisting mainly of a nitrogen base of adenine 
      (ABP) or guanine (GBP) and their derivatives: nucleosides (nitrogen bases plus 
      ribose) and nucleotides (nitrogen bases plus ribose and phosphate). These 
      compounds are very common in nature, especially in a phosphorylated form. There 
      is increasing evidence that purines are involved in the development of different 
      organs such as the heart, skeletal muscle and brain. When brain development is 
      complete, some purinergic mechanisms may be silenced, but may be reactivated in 
      the adult brain/muscle, suggesting a role for purines in regeneration and 
      self-repair. Thus, it is possible that guanosine-5'-triphosphate (GTP) also acts 
      as regulator during the adult phase. However, regarding GBP, no specific receptor 
      has been cloned for GTP or its metabolites, although specific binding sites with 
      distinct GTP affinity characteristics have been found in both muscle and neural 
      cell lines. Finally, even if the cross regulation mechanisms between the two 
      different purines (ABP and GBP) are still largely unknown, it is now possible to 
      hypothesize the existence of specific signal paths for guanosine-based 
      nucleotides that are capable of modulating the intensity and duration of the 
      intracellular signal, particularly in excitable tissues such as brain and muscle.
FAU - Mancinelli, Rosa
AU  - Mancinelli R
AD  - Department of Neuroscience Imaging and Clinical Sciences, University "G. 
      d'Annunzio" of Chieti-Pescara, 66100 Chieti, Italy.
AD  - Interuniversity Institute of Miology (IIM), 66100 Chieti, Italy.
FAU - Fano-Illic, Giorgio
AU  - Fano-Illic G
AD  - Interuniversity Institute of Miology (IIM), 66100 Chieti, Italy.
AD  - Libera Universita di Alcatraz, Santa Cristina di Gubbio, 06024 Gubbio, Italy.
FAU - Pietrangelo, Tiziana
AU  - Pietrangelo T
AD  - Department of Neuroscience Imaging and Clinical Sciences, University "G. 
      d'Annunzio" of Chieti-Pescara, 66100 Chieti, Italy.
AD  - Interuniversity Institute of Miology (IIM), 66100 Chieti, Italy.
FAU - Fulle, Stefania
AU  - Fulle S
AD  - Department of Neuroscience Imaging and Clinical Sciences, University "G. 
      d'Annunzio" of Chieti-Pescara, 66100 Chieti, Italy.
AD  - Interuniversity Institute of Miology (IIM), 66100 Chieti, Italy.
LA  - eng
GR  - Research grant 2007 and 2011/University G.d'Annunzio of Chieti-Pescara/
PT  - Journal Article
PT  - Review
DEP - 20200226
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Guanine Nucleotides)
RN  - 0 (Nucleosides)
RN  - 0 (Nucleotides)
RN  - 0 (Purines)
RN  - 0 (Receptors, Purinergic)
RN  - 12133JR80S (Guanosine)
RN  - 5Z93L87A1R (Guanine)
RN  - 86-01-1 (Guanosine Triphosphate)
RN  - W60KTZ3IZY (purine)
SB  - IM
MH  - Brain/metabolism
MH  - Embryonic Development/physiology
MH  - Guanine/metabolism
MH  - Guanine Nucleotides/metabolism
MH  - Guanosine/*metabolism
MH  - Guanosine Triphosphate/metabolism
MH  - Humans
MH  - Muscles/metabolism
MH  - Nervous System/metabolism
MH  - Nucleosides/metabolism
MH  - Nucleotides/*metabolism
MH  - Purines/*metabolism
MH  - Receptors, Purinergic/metabolism
PMC - PMC7084674
OTO - NOTNLM
OT  - guanine-based purines (GBPs)
OT  - purine receptors
OT  - purinergic signaling
COIS- The authors declare no conflict of interest. The funders had no role in the 
      design of the study; in the collection, analyses, or interpretation of data; in 
      the writing of the manuscript, or in the decision to publish the results.
EDAT- 2020/03/01 06:00
MHDA- 2020/12/15 06:00
PMCR- 2020/03/01
CRDT- 2020/03/01 06:00
PHST- 2020/01/30 00:00 [received]
PHST- 2020/02/20 00:00 [revised]
PHST- 2020/02/25 00:00 [accepted]
PHST- 2020/03/01 06:00 [entrez]
PHST- 2020/03/01 06:00 [pubmed]
PHST- 2020/12/15 06:00 [medline]
PHST- 2020/03/01 00:00 [pmc-release]
AID - ijms21051591 [pii]
AID - ijms-21-01591 [pii]
AID - 10.3390/ijms21051591 [doi]
PST - epublish
SO  - Int J Mol Sci. 2020 Feb 26;21(5):1591. doi: 10.3390/ijms21051591.